Apolipoprotein E genotype in schizophrenia

Journal Article · Tue Apr 09 04:00:00 EDT 1996 · American Journal of Medical Genetics

DOI:https://doi.org/10.1002/ajmg.1320670204· OSTI ID:447669

Joober, R; Lal, S; Bloom, D; Benkelfat, C ^[1]

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1. McGill Research Centre for Schizophrenia, Douglas Hospital, Montreal (Canada); and others

We investigated the association between schizophrenia and the allelic polymorphism in the apolipoprotein E (Apo E) gene in 51 schizophrenic patients and 35 controls. The Apo E4 allele was equally represented in the schizophrenic group (16%) and the control group (20%) suggesting no association between schizophrenia and the Apo E4 allele. The apolipoprotein E (Apo E) is a polymorphic (E2, E3, and E4) lipoprotein involved in the transmembrane transport of cholesterol and is thought to play an important role in neuronal growth and in the central nervous system response to injury, particularly in the hippocampal region. Recent findings strongly suggest that the Apo E4 allele is associated with cognitive deficits in normal and pathological aging, e.g., Alzheimer`s disease. 5 refs., 1 tab.

• Sponsoring Organization: USDOE
• OSTI ID: 447669
• Journal Information: American Journal of Medical Genetics, Journal Name: American Journal of Medical Genetics Journal Issue: 2 Vol. 67; ISSN 0148-7299; ISSN AJMGDA
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
APOLIPOPROTEINS
GENE MUTATIONS
GENETIC MAPPING
GENOTYPE
HEREDITARY DISEASES
MENTAL DISORDERS
NERVOUS SYSTEM DISEASES
PATIENTS
POLYMERASE CHAIN REACTION