A2SD: Accelerating Scientific Innovation Through Autonomous Discovery Systems

Conference · Sat Nov 01 04:00:00 EDT 2025

DOI:https://doi.org/10.1007/978-3-032-07612-0_52· OSTI ID:3007903

Taufer, Michela ^[1]; Ferreira Da Silva, Rafael ^[2]; Mintz, Ben ^[2]; Abolhasani, Milad ^[3]; Badia, Rosa ^[4]; Deelman, Ewa ^[5]; Moore II, Rob ^[2]; Shalf, John ^[6]

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1. University of Tennessee, Knoxville (UTK)
2. ORNL
3. North Carolina State University (NCSU), Raleigh
4. Barcelona Supercomputing Center
5. University of Southern California, Information Sciences Institute
6. Lawrence Berkeley National Laboratory (LBNL)

The 2025 Advancing Autonomous Scientific Discovery (A2SD) workshop convened researchers from academia, national laboratories, and industry to explore the transformative role of autonomy in scientific discovery. The workshop highlighted a convergence of artificial intelligence, robotics, and computational workflows into autonomous systems capable of accelerating the scientific process. Presentations and discussions spanned autonomous experimentation, intelligent workflow orchestration, digital twins, and agent-based systems for managing complex research ecosystems. Key challenges discussed included interoperability across heterogeneous infrastructures, near real-time data management under FAIR principles, reproducibility, and the integration of human oversight. The workshop also emphasized the need for modular software interfaces, federated learning models, and education initiatives to support a next-generation scientific workforce.

• Research Organization: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
• Sponsoring Organization: USDOE Office of Science (SC), Advanced Scientific Computing Research (ASCR) (SC-21); USDOE
• DOE Contract Number: AC05-00OR22725
• OSTI ID: 3007903
• Resource Type: Conference paper/presentation
• Conference Information: High Performance Computing: ISC High Performance 2025 International Workshops - Hamburg, Germany - 6/10/2025-6/13/2025
• Country of Publication: United States
• Language: English