Correlation between induction of meiotic delay and aneuploidy in male mouse germ cells
Conference
·
OSTI ID:28450
- Institut fuer Sauugetiergenetik, Neuherberg (Germany)
No aneuploidy assays are prescribed in any international guidelines for chemical safety testing up to now. The CEC-sponsored Aneuploidy Project has the aim to validate test methods for aneuploidy induction which could be used as screening tests. Furthermore, one of the major goals is to develop an understanding of mechanisms by which aneuploidy is induced. The present paper describes the investigation of meiotic delay and aneuploidy induction with the drug diazepam (DZ), the environmentally important mutagen acrylamide (AA) and the spindle poison colchicine (COL), which is used as a positive control. The time course of events was investigated. It is concluded that the assessment of meiotic delay can be used to preselect chemicals which require evaluation of aneuploidy induction during MMI in male germ cells.
- OSTI ID:
- 28450
- Report Number(s):
- CONF-9210475--Cond.; CNN: Contract STEP CT91-0159
- Country of Publication:
- United States
- Language:
- English
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