The relationship between chemically-induced meiotic delay and aneuploidy in mouse oocytes and zygotes

Conference · Fri Dec 31 04:00:00 EST 1993

OSTI ID:28449

Mailhes, J B; Marchetti, F ^[1]

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1. Louisiana State Univ. Medical Center, Shreveport, LA (United States)

Aneuploidy is a relatively common genetic disorder that results in human morbidity and mortality. Approximately 30% of embryonic and fetal deaths and 3.45 per thousand livebirths are associated with an abnormal number of chromosomes. Unfortunately, very little is known about the etiology and mechanism of chromosome missegregation. This situation dictates that considerable research be directed toward understanding the causes of aneuploidy. Although several hypotheses have been advanced for the etiology of aneuploidy, there still exists a paucity of information about the direct cuases and mechanisms of aneuploidy production. Without such specific knowledge, there is little hope of reducing the incidence of aneuploidy in humans. Some progress has been made. We now know that various chemicals can induce aneuploidy by interacting with certain cellular organelles, especially components of the spindle apparatus. These results have been demonstrated in various organisms and cell types both in vivo and in vitro. Since the ultimate objective of aneuploidy research is to obtain information that can be used to reduce the aneuploidy burden in humans, we have concentrated our research efforts on studying chemically-induced aneuploidy in mammalian germ cells and zygotes.

• OSTI ID: 28449
• Report Number(s): CONF-9210475--Cond.
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
ANEUPLOIDY
ANTIMITOTIC DRUGS
BIOASSAY
CELL DIVISION
CHROMOSOMAL ABERRATIONS
COLCHICINE
MICE
OOCYTES
VINBLASTINE
ZYGOTES