Gene for ataxia-telangiectasia complementation group D (ATDC)

Patent · 07 March 1995

OSTI ID:27712

Murnane, J P; Painter, R B; Kapp, L N; Yu, L C

Disclosed herein is a new gene, an AT gene for complementation group D, the ATDC gene and fragments thereof. Nucleic acid probes for the gene are provided as well as proteins encoded by the gene, cDNA therefrom, preferably a 3 kilobase (kb) cDNA, and recombinant nucleic acid molecules for expression of the proteins. Further disclosed are methods to detect mutations in the gene, preferably methods employing the polymerase chain reaction (PCR). Also disclosed are methods to detect AT genes from other AT complementation groups. 30 figs.

• Research Organization: University of California
• Sponsoring Organization: USDOE
• DOE Contract Number: W-7405-ENG-48; AC03-76SF01012
• Assignee: Univ. of California, Oakland, CA (United States)
• Patent Number(s): US 5,395,767/A/
• Application Number: PAN: 7-903,466
• OSTI ID: 27712
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
DNA-CLONING
GENE MUTATIONS
GENE REGULATION
GENES
MEASURING METHODS
NERVOUS SYSTEM DISEASES
VASCULAR DISEASES