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Title: An accelerator-based epithermal photoneutron source for boron neutron capture therapy

Abstract

Boron neutron capture therapy is an experimental binary cancer radiotherapy modality in which a boronated pharmaceutical that preferentially accumulates in malignant tissue is first administered, followed by exposing the tissue in the treatment volume to a thermal neutron field. Current usable beams are reactor-based but a viable alternative is the production of an epithermal neutron beam from an accelerator. Current literature cites various proposed accelerator-based designs, most of which are based on proton beams with beryllium or lithium targets. This dissertation examines the efficacy of a novel approach to BNCT treatments that incorporates an electron linear accelerator in the production of a photoneutron source. This source may help to resolve some of the present concerns associated with accelerator sources, including that of target cooling. The photoneutron production process is discussed as a possible alternate source of neutrons for eventual BNCT treatments for cancer. A conceptual design to produce epithermal photoneutrons by high photons (due to bremsstrahlung) impinging on deuterium targets is presented along with computational and experimental neutron production data. A clinically acceptable filtered epithermal neutron flux on the order of 10 7 neutrons per second per milliampere of electron current is shown to be obtainable. Additionally, the neutron beammore » is modified and characterized for BNCT applications by employing two unique moderating materials (an Al/AlF 3 composite and a stacked Al/Teflon design) at various incident electron energies.« less

Authors:
 [1]
  1. Georgia Inst. of Technology, Atlanta, GA (United States)
Publication Date:
Research Org.:
Lockheed Idaho Technologies Co., Idaho Falls, ID (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
266744
Report Number(s):
INEL-96/0212
ON: DE96013301; TRN: 96:017052
DOE Contract Number:  
AC07-94ID13223
Resource Type:
Thesis/Dissertation
Resource Relation:
Other Information: DN: Thesis submitted to Georgia Inst. of Tech., Atlanta, GA (US); TH: Thesis (Ph.D.); PBD: Apr 1996
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 07 ISOTOPE AND RADIATION SOURCE TECHNOLOGY; 43 PARTICLE ACCELERATORS; NEUTRON CAPTURE THERAPY; NEUTRON SOURCES; NEOPLASMS; DESIGN; LINEAR ACCELERATORS; MODERATORS; EPITHERMAL NEUTRONS; RECOMMENDATIONS; PHOTONEUTRONS

Citation Formats

Mitchell, Hannah E. An accelerator-based epithermal photoneutron source for boron neutron capture therapy. United States: N. p., 1996. Web. doi:10.2172/266744.
Mitchell, Hannah E. An accelerator-based epithermal photoneutron source for boron neutron capture therapy. United States. doi:10.2172/266744.
Mitchell, Hannah E. Mon . "An accelerator-based epithermal photoneutron source for boron neutron capture therapy". United States. doi:10.2172/266744. https://www.osti.gov/servlets/purl/266744.
@article{osti_266744,
title = {An accelerator-based epithermal photoneutron source for boron neutron capture therapy},
author = {Mitchell, Hannah E.},
abstractNote = {Boron neutron capture therapy is an experimental binary cancer radiotherapy modality in which a boronated pharmaceutical that preferentially accumulates in malignant tissue is first administered, followed by exposing the tissue in the treatment volume to a thermal neutron field. Current usable beams are reactor-based but a viable alternative is the production of an epithermal neutron beam from an accelerator. Current literature cites various proposed accelerator-based designs, most of which are based on proton beams with beryllium or lithium targets. This dissertation examines the efficacy of a novel approach to BNCT treatments that incorporates an electron linear accelerator in the production of a photoneutron source. This source may help to resolve some of the present concerns associated with accelerator sources, including that of target cooling. The photoneutron production process is discussed as a possible alternate source of neutrons for eventual BNCT treatments for cancer. A conceptual design to produce epithermal photoneutrons by high photons (due to bremsstrahlung) impinging on deuterium targets is presented along with computational and experimental neutron production data. A clinically acceptable filtered epithermal neutron flux on the order of 107 neutrons per second per milliampere of electron current is shown to be obtainable. Additionally, the neutron beam is modified and characterized for BNCT applications by employing two unique moderating materials (an Al/AlF3 composite and a stacked Al/Teflon design) at various incident electron energies.},
doi = {10.2172/266744},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1996},
month = {4}
}

Thesis/Dissertation:
Other availability
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