Evidence for apolipoprotein E {epsilon}4 association in early-onset Alzheimer`s patients with late-onset relatives
Journal Article
·
· American Journal of Medical Genetics
- INSERM, Rouen (France); and others
Recently several reports have extended the apolipoprotein E (APOE) {epsilon}4 association found in late-onset Alzheimer`s disease (LOAD) patients to early-onset (EO) AD patients. We have studied this question in a large population of 119 EOAD patients (onset {<=}60 years) in which family history was carefully assessed and in 109 controls. We show that the APOE {epsilon}A allele frequency is increased only in the subset of patients who belong to families where LOAD secondary cases are present. Our sampling scheme permits us to demonstrate that, for an individual, bearing at least one {epsilon}4 allele increases both the risk of AD before age 60 and the probability of belonging to a family with late-onset affected subjects. Our results suggest that a subset of EOAD cases shares a common determinism with LOAD cases. 19 refs., 3 tabs.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 254409
- Journal Information:
- American Journal of Medical Genetics, Journal Name: American Journal of Medical Genetics Journal Issue: 6 Vol. 60; ISSN 0148-7299; ISSN AJMGDA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Association of apolipoprotein E allele {epsilon}4 with late-onset sporadic Alzheimer`s disease
Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
Allelic association but only weak evidence for linkage to the apolipoprotein E locus in late-onset Swedish Alzheimer families
Journal Article
·
Thu Sep 15 00:00:00 EDT 1994
· American Journal of Medical Genetics
·
OSTI ID:135927
Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
Journal Article
·
Fri Aug 13 00:00:00 EDT 1993
· Science (Washington, D.C.); (United States)
·
OSTI ID:5483040
Allelic association but only weak evidence for linkage to the apolipoprotein E locus in late-onset Swedish Alzheimer families
Journal Article
·
Fri May 31 00:00:00 EDT 1996
· American Journal of Medical Genetics
·
OSTI ID:441160