Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

Journal Article · Fri Aug 13 00:00:00 EDT 1993 · Science (Washington, D.C.); (United States)

DOI:https://doi.org/10.1126/science.8346443· OSTI ID:5483040

Corder, E H; Saunders, A M; Strittmatter, W J; Gaskell, P C; Roses, A D; Petricak-Vance, M A ^[1]; Schmechel, D E ^[2]; Small, G W ^[3]; Haines, J L ^[4]

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1. Duke Univ. Medical Center, Durham, NC (United States)
2. Duke Univ. Medical Center, Durham, NC (United States) Durham VA Medical Center, CA (United States)
3. Univ. of California, Los Angeles, CA (United States)
4. Massachusetts General Hospital, Charlestown, MA (United States)

The apolipoprotein E type 4 allele (APOE-[epsilon]4) is genetically associated with the common late onset familial and sporadic forms of Alzheimer's disease (AD). Risk for AD increased from 20% to 90% and mean age at onset decreased from 84 to 68 years with increasing number of APOE-[epsilon]4 alleles in 42 families with late onset AD. Thus APOE-[epsilon]4 gene dose is a major risk factor for late onset AD and, in these families, homozygosity for APOE-[epsilon]4 was virtually sufficient to cause AD by age 80.

• OSTI ID: 5483040
• Journal Information: Science (Washington, D.C.); (United States), Vol. 261:5123; ISSN 0036-8075
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
APOLIPOPROTEINS
GENES
NERVOUS SYSTEM DISEASES
RISK ASSESSMENT
HUMAN POPULATIONS
SCREENING
DISEASES
LIPIDS
LIPOPROTEINS
ORGANIC COMPOUNDS
POPULATIONS
PROTEINS
550400* - Genetics