Potential linkage for schizophrenia on chromosome 22q12-q13: A replication study
- Univ. of Munich (Germany); and others
In an attempt to replicate a potential linkage on chromosome 22q12-q13.1 reported by Pulver et al., we have analyzed 4 microsatellite markers which span this chromosomal region, including the IL2RB locus, for linkage with schizophrenia in 30 families from Israel and Germany. Linkage analysis by pairwise lod score analysis as well as by multipoint analysis did not provide evidence for a single major gene locus. However, a lod score of Z{sub max} = 0.612 was obtained for a dominant model of inheritance with the marker D22S304 at recombination fraction 0.2 by pairwise analysis. In addition, using a nonparametric method, sib pair analysis, a P value of 0.068 corresponding to a lod score of 0.48 was obtained for this marker. This finding, together with those of Pulver et al., is suggestive of a genetic factor in this region, predisposing for schizophrenia in a subset of families. Further studies using nonparametric methods should be conducted in order to clarify this point. 32 refs., 1 fig., 4 tabs.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 254389
- Journal Information:
- American Journal of Medical Genetics, Vol. 60, Issue 5; Other Information: PBD: 9 Oct 1995
- Country of Publication:
- United States
- Language:
- English
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