Search for a schizophrenia susceptibility locus of human chromosome 22

Journal Article · Wed Jun 15 00:00:00 EDT 1994 · American Journal of Medical Genetics

OSTI ID:91089

Coon, H; Hoff, M; Holik, J ^[1]

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1. Univ. of Utah Medical Center, Salt Lake City, UT (United States); and others

We used 10 highly informative DNA polymorphic markers and genetic linkage analysis to examine whether a gene locus predisposing to schizophrenia is located on chromosome 22, in 105 families with schizophrenia and schizoaffective disorder. The LOD score method, including analysis for heterogeneity, provided no conclusive evidence of linkage under a dominant, recessive, or penetrance free model of inheritance. Affected sib-pair analysis was inconclusive. Affected Pedigree Member (APM) analysis gave only suggestive evidence for linkage. Multipoint APM analysis, using 4 adjacent loci including D22S281 and IL2RB, a region of interest from the APM analysis, gave non-significant results for the three different weighting functions. 18 refs., 1 fig., 7 tabs.

• OSTI ID: 91089
• Journal Information: American Journal of Medical Genetics, Journal Name: American Journal of Medical Genetics Journal Issue: 2 Vol. 54; ISSN 0148-7299; ISSN AJMGDA
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
BIOLOGICAL MARKERS
GENES
GENETIC MAPPING
GENETICS
HUMAN CHROMOSOME 22
MENTAL DISORDERS
PATIENTS
STATISTICAL MODELS