Characterization and mapping of the Rapsn gene encoding the 43-kDa acetylocholine receptor-associated protein
- Washington Univ. Medical School, St Louis, MO (United States); and others
The authors have cloned and characterized mouse genomic DNA containing the gene for the 43-kDa acetylcholine receptor-associated protein. The gene extends over 12 kb and consists of 8 exons. RNase protection and sequence analysis have been used to define the intron/exon boundaries including 174 and 214 bp of 5{prime} and 3{prime} untranslated sequence in exons 1 and 8, respectively. Interestingly, the exon/intron organization is consistent with structural domains predicted from amino acid sequence conservation among 3 species of 43K. Finally, the 43K locus, designated Rapsn, has been mapped to the central region of mouse chromosome 2. 11 refs., 2 figs.
- OSTI ID:
- 250267
- Journal Information:
- Genomics, Journal Name: Genomics Journal Issue: 2 Vol. 24; ISSN GNMCEP; ISSN 0888-7543
- Country of Publication:
- United States
- Language:
- English
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