Regional localization of the human integrin {beta}{sub 6} gene (ITGB6) to chromosome 2q24-q31
- Universidad Autonoma de Madrid (Spain)
The heterodimer {alpha}{sub v}{beta}{sub 6} acts as a fibronectin receptor for human carcinoma cells. The authors report here the regional localization of the {beta}{sub 6} gene to 2q24-q31 by fluorescence in situ hybridization coupled with GTG-banding. This gene is located close to the region to which genes coding for the {alpha} subunits of the integrins VLA-4 and vitronectin receptor (ITGA4 and ITGAV, respectively) have been previously mapped (2q31-q32). These data suggest a proximal position of the integrin {beta}{sub 6} locus (ITGB6) on this integrin gene cluster. Futhermore, double-labeling in situ hybridization experiments performed with {alpha}{sub 4} and {alpha}{sub v} probes indicated a telomeric position of ITGAV with respect to ITGA4. 22 refs., 2 figs.
- OSTI ID:
- 250057
- Journal Information:
- Genomics, Journal Name: Genomics Journal Issue: 3 Vol. 21; ISSN GNMCEP; ISSN 0888-7543
- Country of Publication:
- United States
- Language:
- English
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