Amplitude- and frequency-dependent activation of layer II/III neurons by intracortical microstimulation

Wu, Guangying K.; Ardeshirpour, Yasaman; Mastracchio, Christina; Kent, Jordan; Caiola, Michael; Ye, Meijun

doi:10.1016/j.isci.2023.108140

Amplitude- and frequency-dependent activation of layer II/III neurons by intracortical microstimulation

Journal Article · Fri Oct 06 00:00:00 EDT 2023 · iScience

DOI:https://doi.org/10.1016/j.isci.2023.108140· OSTI ID:2471351

Wu, Guangying K. ^[1]; Ardeshirpour, Yasaman ^[1]; Mastracchio, Christina ^[1]; Kent, Jordan ^[2]; Caiola, Michael ^[1]; Ye, Meijun ^[1]

US Food and Drug Administration (USFDA), Silver Spring, MD (United States)
US Food and Drug Administration (USFDA), Silver Spring, MD (United States); Society for Neuroscience, Washington, DC (United States)

Intracortical microstimulation (ICMS) has been used for the development of brain machine interfaces. However, further understanding about the spatiotemporal responses of neurons to different electrical stimulation parameters is necessary to inform the design of optimal therapies. In this study, we employed in vivo electrophysiological recording, two-photon calcium imaging, and electric field simulation to evaluate the acute effect of ICMS on layer II/III neurons. Our results show that stimulation frequency non-linearly modulates neuronal responses, whereas the magnitude of responses is linearly correlated to the electric field strength and stimulation amplitude before reaching a steady state. Temporal dynamics of neurons’ responses depends more on stimulation frequency and their distance to the stimulation electrode. In addition, amplitude-dependent post-stimulation suppression was observed within ~500 μm of the stimulation electrode, as evidenced by both calcium imaging and local field potentials. These findings provide insights for selecting stimulation parameters to achieve desirable spatiotemporal specificity of ICMS.

View Accepted Manuscript (DOE)

Research Organization:: Oak Ridge Institute for Science and Education (ORISE), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE Office of Science (SC)

Grant/Contract Number:: SC0014664

OSTI ID:: 2471351

Journal Information:: iScience, Journal Name: iScience Journal Issue: 11 Vol. 26; ISSN 2589-0042

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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