Previous exposure to Spike-providing parental strains confers neutralizing immunity to XBB lineage and other SARS-CoV-2 recombinants in the context of vaccination

Suryawanshi, Rahul K.; Taha, Taha Y.; McCavitt-Malvido, Maria; Silva, Ines; Khalid, Mir M.; Syed, Abdullah M.; Chen, Irene P.; Saldhi, Prachi; Sreekumar, Bharath; Montano, Mauricio; Foresythe, Kafaya; Tabata, Takako; Kumar, G. Renuka; Sotomayor-Gonzalez, Alicia; Servellita, Venice; Gliwa, Amelia; Nguyen, Jenny; Kojima, Noah; Arellanor, Teresa; Bussanich, Aallyah; Hess, Victoria; Shacreaw, Maria; Lopez, Lauren; Brobeck, Matthew; Turner, Fred; Wang, Yuzhu; Ghazarian, Sydney; Davis, Gregg; Rodriguez, Diviana; Doudna, Jennifer; Spraggon, Lee; Chiu, Charles Y.; Ott, Melanie

doi:10.1080/22221751.2023.2270071

Previous exposure to Spike-providing parental strains confers neutralizing immunity to XBB lineage and other SARS-CoV-2 recombinants in the context of vaccination

Journal Article · Tue Oct 31 00:00:00 EDT 2023 · Emerging Microbes & Infections

DOI:https://doi.org/10.1080/22221751.2023.2270071· OSTI ID:2470848

Suryawanshi, Rahul K. ^[1]; Taha, Taha Y. ^[1]; McCavitt-Malvido, Maria ^[1]; Silva, Ines ^[2]; Khalid, Mir M. ^[1]; Syed, Abdullah M. ^[3]; Chen, Irene P. ^[4]; Saldhi, Prachi ^[5]; Sreekumar, Bharath ^[1]; Montano, Mauricio ^[1]; Foresythe, Kafaya ^[5]; Tabata, Takako ^[1]; Kumar, G. Renuka ^[1]; Sotomayor-Gonzalez, Alicia ^[5]; Servellita, Venice ^[5]; Gliwa, Amelia ^[5]; Nguyen, Jenny ^[5]; Kojima, Noah ^[2]; Arellanor, Teresa ^[2]; Bussanich, Aallyah ^[2] more »

Gladstone Institutes, San Francisco, CA (United States)
Curative Inc., Monrovia, CA (United States)
Gladstone Institutes, San Francisco, CA (United States); University of California, Berkeley, CA (United States)
Gladstone Institutes, San Francisco, CA (United States); University of California, Berkeley, CA (United States); Univ. of California, San Francisco, CA (United States). Quantitative Biosciences Institute COVID-19 Research Group (QCRG)
Univ. of California, San Francisco, CA (United States)
Gladstone Institutes, San Francisco, CA (United States); University of California, Berkeley, CA (United States); Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Univ. of California, San Francisco, CA (United States); University of California, Berkeley, CA (United States); UCSF-Abbott Viral Diagnostics and Discovery Center, San Francisco, CA (United States)
Gladstone Institutes, San Francisco, CA (United States); University of California, Berkeley, CA (United States); Univ. of California, San Francisco, CA (United States). Quantitative Biosciences Institute COVID-19 Research Group (QCRG); Chan Zuckerberg Biohub, San Francisco, CA (United States)

The emergence of SARS-CoV-2 recombinants is of particular concern as they can result in a sudden increase in immune evasion due to antigenic shift. Recent recombinants XBB and XBB.1.5 have higher transmissibility than previous recombinants such as “Deltacron.” We hypothesized that immunity to a SARS-CoV-2 recombinant depends on prior exposure to its parental strains. To test this hypothesis, we examined whether Delta or Omicron (BA.1 or BA.2) immunity conferred through infection, vaccination, or breakthrough infection could neutralize Deltacron and XBB/XBB.1.5 recombinants. We found that Delta, BA.1, or BA.2 breakthrough infections provided better immune protection against Deltacron and its parental strains than did the vaccine booster. None of the sera were effective at neutralizing the XBB lineage or its parent BA.2.75.2, except for the sera from the BA.2 breakthrough group. These results support our hypothesis. In turn, our findings underscore the importance of multivalent vaccines that correspond to the antigenic profile of circulating variants of concern and of variant-specific diagnostics that may guide public health and individual decisions in response to emerging SARS-CoV-2 recombinants.

View Accepted Manuscript (DOE)

Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: National Institutes of Health (NIH); US Centers for Disease Control and Prevention (CDC); USDOE

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 2470848

Journal Information:: Emerging Microbes & Infections, Journal Name: Emerging Microbes & Infections Journal Issue: 2 Vol. 12; ISSN 2222-1751

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United States

Language:: English

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59 BASIC BIOLOGICAL SCIENCES
Humoral immunity
Immunology
Infectious diseases
Microbiology
Neutralization
Recombinants
SARS-CoV-2
Vaccine

Previous exposure to Spike-providing parental strains confers neutralizing immunity to XBB lineage and other SARS-CoV-2 recombinants in the context of vaccination Suryawanshi, Rahul K.; Taha, Taha Y.; McCavitt-Malvido, Maria https://doi.org/10.6084/m9.figshare.24420590.v1 The current record is supplemented by this other	other	January 2023
Previous exposure to Spike-providing parental strains confers neutralizing immunity to XBB lineage and other SARS-CoV-2 recombinants in the context of vaccination Suryawanshi, Rahul K.; Taha, Taha Y.; McCavitt-Malvido, Maria https://doi.org/10.6084/m9.figshare.24420590.v2 The current record is supplemented by this dataset	dataset	January 2023

Previous exposure to Spike-providing parental strains confers neutralizing immunity to XBB lineage and other SARS-CoV-2 recombinants in the context of vaccination

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