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Neutralization escape by SARS-CoV-2 Omicron subvariant BA.2.86

Journal Article · · Vaccine
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  1. Beth Israel Deaconess Medical Center, Boston, MA (United States)
  2. Los Alamos National Laboratory (LANL), Santa Fe, NM (United States)
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The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) variant BA.2.86 has over 30 mutations in spike compared with BA.2 and XBB.1.5, which raised the possibility that BA.2.86 might evade neutralizing antibodies (NAbs) induced by vaccination or infection. In this study, we show that NAb titers are substantially lower to BA.2.86 compared with BA.2 but are similar or slightly higher than to other current circulating variants, including XBB.1.5, EG.5.1, and FL.1.5.1. Moreover, NAb titers against all these variants were higher in vaccinated individuals with a history of XBB.1.5 infection compared with vaccinated individuals with no history of XBB.1.5 infection, suggesting the potential utility of the monovalent XBB.1.5 mRNA boosters.
Research Organization:
Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
Sponsoring Organization:
National Institutes of Health (NIH); USDOE National Nuclear Security Administration (NNSA)
Grant/Contract Number:
89233218CNA000001
OSTI ID:
2204211
Report Number(s):
LA-UR--23-30025
Journal Information:
Vaccine, Journal Name: Vaccine Journal Issue: 47 Vol. 41; ISSN 0264-410X
Publisher:
ElsevierCopyright Statement
Country of Publication:
United States
Language:
English

References (6)

Receptor binding and priming of the spike protein of SARS-CoV-2 for membrane fusion journal September 2020
SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies journal October 2020
Antibody evasion properties of SARS-CoV-2 Omicron sublineages journal March 2022
Neutralization Escape by SARS-CoV-2 Omicron Subvariants BA.2.12.1, BA.4, and BA.5 journal July 2022
Substantial Neutralization Escape by SARS-CoV-2 Omicron Variants BQ.1.1 and XBB.1 journal February 2023
Project NextGen — Defeating SARS-CoV-2 and Preparing for the Next Pandemic journal August 2023

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Related Subjects

60 APPLIED LIFE SCIENCES
BA.2.86
SARS-CoV-2
biological science
immune evasion
mRNA
neutralizing antibody
vaccine
variant