Tau accumulation and atrophy predict amyloid independent cognitive decline in aging

Fonseca, Corrina S.; Baker, Suzanne L.; Dobyns, Lindsey; Janabi, Mustafa; Jagust, William J.; Harrison, Theresa M.

doi:10.1002/alz.13654

Tau accumulation and atrophy predict amyloid independent cognitive decline in aging

Journal Article · Thu Feb 08 23:00:00 EST 2024 · Alzheimer's & Dementia

DOI:https://doi.org/10.1002/alz.13654· OSTI ID:2470691

^[1]; Baker, Suzanne L. ^[2]; Dobyns, Lindsey ^[1]; Janabi, Mustafa ^[2]; Jagust, William J. ^[3]; Harrison, Theresa M. ^[1]

Univ. of California, Berkeley, CA (United States)
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Univ. of California, Berkeley, CA (United States); Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

INTRODUCTION: Amyloid beta (Aβ) and tau pathology are cross-sectionally associated with atrophy and cognitive decline in aging and Alzheimer's disease (AD). METHODS: We investigated relationships between concurrent longitudinal measures of Aβ (Pittsburgh compound B [PiB] positron emission tomography [PET]), tau (flortaucipir [FTP] PET), atrophy (structural magnetic resonance imaging), episodic memory (EM), and non-memory (NM) in 78 cognitively healthy older adults (OA). RESULTS: Entorhinal FTP change was correlated with EM decline regardless of Aβ, but meta-temporal FTP and global PiB change were only associated with EM and NM decline in Aβ+ OA. Voxel-wise analyses revealed significant associations between temporal lobe FTP change and EM decline in all groups. PiB and FTP change were not associated with structural change, suggesting a functional or microstructural mechanism linking these measures to cognitive decline. DISCUSSION: Our results show that longitudinal Aβ is linked to cognitive decline only in the presence of elevated Aβ, but longitudinal temporal lobe tau is associated with memory decline regardless of Aβ status.

View Accepted Manuscript (DOE)

Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE; National Institutes of Health (NIH)

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 2470691

Journal Information:: Alzheimer's & Dementia, Journal Name: Alzheimer's & Dementia Journal Issue: 4 Vol. 20; ISSN 1552-5260

Publisher:: WileyCopyright Statement

Country of Publication:: United States

Language:: English

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60 APPLIED LIFE SCIENCES
Alzheimer's disease
aging
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episodic memory
magnetic resonance imaging
non-memory cognition
positron emission tomography
tau

Tau accumulation and atrophy predict amyloid independent cognitive decline in aging

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