Distinct effects of beta-amyloid and tau on cortical thickness in cognitively healthy older adults

Harrison, Theresa M.; Du, Richard; Klencklen, Giuliana; Baker, Suzanne L.; Jagust, William J.

doi:10.1002/alz.12249

Distinct effects of beta-amyloid and tau on cortical thickness in cognitively healthy older adults

Journal Article · Mon Dec 14 23:00:00 EST 2020 · Alzheimer's & Dementia

DOI:https://doi.org/10.1002/alz.12249· OSTI ID:1826560

Harrison, Theresa M. ^[1]; Du, Richard ^[1]; Klencklen, Giuliana ^[1]; Baker, Suzanne L. ^[2]; Jagust, William J. ^[3]

Univ. of California, Berkeley, CA (United States)
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Univ. of California, Berkeley, CA (United States); Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

Published reports of associations between β-amyloid (Aβ) and cortical integrity conflict. Tau biomarkers may help elucidate the complex relationship between pathology and neurodegeneration in aging. We measured cortical thickness using magnetic resonance imaging, Aβ using Pittsburgh compound B positron emission tomography (PiB-PET), and tau using flortaucipir (FTP)-PET in 125 cognitively normal older adults. We examined relationships among PET measures, cortical thickness, and cognition. Cortical thickness was reduced in PiB+/FTP+ participants compared to the PiB+/FTP– and PiB–/FTP– groups. Continuous PiB associations with cortical thickness were weak but positive in FTP– participants and negative in FTP+. FTP strongly negatively predicted thickness regardless of PiB status. FTP was associated with memory and cortical thickness, and mediated the association of PiB with memory. Past findings linking Aβ and cortical thickness are likely weak due to opposing effects of Aβ on cortical thickness relative to tau burden. Tau, in contrast to Aβ, is strongly related to cortical thickness and memory.

View Accepted Manuscript (DOE)

Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER)

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1826560

Journal Information:: Alzheimer's & Dementia, Journal Name: Alzheimer's & Dementia Journal Issue: 7 Vol. 17; ISSN 1552-5260

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

References (35)

Amyloid-β associated cortical thinning in clinically normal elderly Becker, J. Alex; Hedden, Trey; Carmasin, Jeremy Annals of Neurology, Vol. 69, Issue 6 https://doi.org/10.1002/ana.22333	journal	March 2011
Cerebrospinal fluid β-amyloid and phospho-tau biomarker interactions affecting brain structure in preclinical Alzheimer disease: CSF β-Amyloid and p-Tau in AD Fortea, Juan; Vilaplana, Eduard; Alcolea, Daniel Annals of Neurology, Vol. 76, Issue 2 https://doi.org/10.1002/ana.24186	journal	June 2014
Covarying alterations in Aβ deposition, glucose metabolism, and gray matter volume in cognitively normal elderly: Aβ, Metabolism, Gray Matter Volume, and Aging Oh, Hwamee; Habeck, Christian; Madison, Cindee Human Brain Mapping, Vol. 35, Issue 1 https://doi.org/10.1002/hbm.22173	journal	September 2012
Cortical Surface-Based Analysis Dale, Anders M.; Fischl, Bruce; Sereno, Martin I. NeuroImage, Vol. 9, Issue 2 https://doi.org/10.1006/nimg.1998.0395	journal	February 1999
Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers Jack, Clifford R.; Knopman, David S.; Jagust, William J. The Lancet Neurology, Vol. 12, Issue 2 https://doi.org/10.1016/S1474-4422(12)70291-0	journal	February 2013
Cognitively Preserved Subjects with Transitional Cerebrospinal Fluid ß-Amyloid 1-42 Values Have Thicker Cortex in Alzheimer's Disease Vulnerable Areas Fortea, Juan; Sala-Llonch, Roser; Bartrés-Faz, David Biological Psychiatry, Vol. 70, Issue 2 https://doi.org/10.1016/j.biopsych.2011.02.017	journal	July 2011
Considerations and code for partial volume correcting [ 18 F]-AV-1451 tau PET data Baker, Suzanne L.; Maass, Anne; Jagust, William J. Data in Brief, Vol. 15 https://doi.org/10.1016/j.dib.2017.10.024	journal	December 2017
National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease Hyman, Bradley T.; Phelps, Creighton H.; Beach, Thomas G. Alzheimer's & Dementia, Vol. 8, Issue 1 https://doi.org/10.1016/j.jalz.2011.10.007	journal	January 2012
Decreased hippocampal metabolism in high‐amyloid mild cognitive impairment Hanseeuw, Bernard J.; Schultz, Aaron P.; Betensky, Rebecca A. Alzheimer's & Dementia, Vol. 12, Issue 12 https://doi.org/10.1016/j.jalz.2016.06.2357	journal	July 2016
Defining imaging biomarker cut points for brain aging and Alzheimer's disease Jack, Clifford R.; Wiste, Heather J.; Weigand, Stephen D. Alzheimer's & Dementia, Vol. 13, Issue 3 https://doi.org/10.1016/j.jalz.2016.08.005	journal	March 2017
Cortical microstructural changes along the Alzheimer's disease continuum Montal, Victor; Vilaplana, Eduard; Alcolea, Daniel Alzheimer's & Dementia, Vol. 14, Issue 3 https://doi.org/10.1016/j.jalz.2017.09.013	journal	October 2017
NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease Jack, Clifford R.; Bennett, David A.; Blennow, Kaj Alzheimer's & Dementia, Vol. 14, Issue 4 https://doi.org/10.1016/j.jalz.2018.02.018	journal	April 2018
Early cortical thickness changes predict β-amyloid deposition in a mouse model of Alzheimer's disease Grand'Maison, Marilyn; Zehntner, Simone P.; Ho, Ming-Kai Neurobiology of Disease, Vol. 54 https://doi.org/10.1016/j.nbd.2013.02.005	journal	June 2013
Neuronal driven pre-plaque inflammation in a transgenic rat model of Alzheimer's disease Hanzel, Cecilia E.; Pichet-Binette, Alexa; Pimentel, Luisa S. B. Neurobiology of Aging, Vol. 35, Issue 10 https://doi.org/10.1016/j.neurobiolaging.2014.03.026	journal	October 2014
Association of plasma β-amyloid with MRI markers of structural brain aging the 3-City Dijon study Kaffashian, Sara; Tzourio, Christophe; Soumaré, Aïcha Neurobiology of Aging, Vol. 36, Issue 10 https://doi.org/10.1016/j.neurobiolaging.2015.03.016	journal	October 2015
Cerebrospinal fluid progranulin is associated with increased cortical thickness in early stages of Alzheimer's disease Batzu, Lucia; Westman, Eric; Pereira, Joana B. Neurobiology of Aging, Vol. 88 https://doi.org/10.1016/j.neurobiolaging.2019.12.012	journal	April 2020
An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest Desikan, Rahul S.; Ségonne, Florent; Fischl, Bruce NeuroImage, Vol. 31, Issue 3 https://doi.org/10.1016/j.neuroimage.2006.01.021	journal	July 2006
Comparison of multiple tau-PET measures as biomarkers in aging and Alzheimer's disease Maass, Anne; Landau, Susan; Baker, Suzanne L. NeuroImage, Vol. 157 https://doi.org/10.1016/j.neuroimage.2017.05.058	journal	August 2017
PET Imaging of Tau Deposition in the Aging Human Brain Schöll, Michael; Lockhart, Samuel N.; Schonhaut, Daniel R. Neuron, Vol. 89, Issue 5 https://doi.org/10.1016/j.neuron.2016.01.028	journal	March 2016
Does amyloid deposition produce a specific atrophic signature in cognitively normal subjects? Whitwell, Jennifer L.; Tosakulwong, Nirubol; Weigand, Stephen D. NeuroImage: Clinical, Vol. 2 https://doi.org/10.1016/j.nicl.2013.01.006	journal	January 2013
Kinetic Modeling of Amyloid Binding in Humans using PET Imaging and Pittsburgh Compound-B Price, Julie C.; Klunk, William E.; Lopresti, Brian J. Journal of Cerebral Blood Flow & Metabolism, Vol. 25, Issue 11 https://doi.org/10.1038/sj.jcbfm.9600146	journal	May 2005
Measuring the thickness of the human cerebral cortex from magnetic resonance images Fischl, B.; Dale, A. M. Proceedings of the National Academy of Sciences, Vol. 97, Issue 20 https://doi.org/10.1073/pnas.200033797	journal	September 2000
Larger temporal volume in elderly with high versus low beta-amyloid deposition Chételat, Gaël; Villemagne, Victor L.; Pike, Kerryn E. Brain, Vol. 133, Issue 11 https://doi.org/10.1093/brain/awq187	journal	August 2010
Existing Pittsburgh Compound-B positron emission tomography thresholds are too high: statistical and pathological evaluation Villeneuve, Sylvia; Rabinovici, Gil D.; Cohn-Sheehy, Brendan I. Brain, Vol. 138, Issue 7 https://doi.org/10.1093/brain/awv112	journal	May 2015
Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer’s disease Ossenkoppele, Rik; Schonhaut, Daniel R.; Schöll, Michael Brain, Vol. 139, Issue 5 https://doi.org/10.1093/brain/aww027	journal	March 2016
The bivariate distribution of amyloid-β and tau: relationship with established neurocognitive clinical syndromes Jack, Clifford R.; Wiste, Heather J.; Botha, Hugo Brain, Vol. 142, Issue 10 https://doi.org/10.1093/brain/awz268	journal	September 2019
Relationships between Beta-Amyloid and Functional Connectivity in Different Components of the Default Mode Network in Aging Mormino, Elizabeth C.; Smiljic, Andre; Hayenga, Amynta O. Cerebral Cortex, Vol. 21, Issue 10 https://doi.org/10.1093/cercor/bhr025	journal	March 2011
Distribution Volume Ratios without Blood Sampling from Graphical Analysis of PET Data Logan, Jean; Fowler, Joanna S.; Volkow, Nora D. Journal of Cerebral Blood Flow & Metabolism, Vol. 16, Issue 5 https://doi.org/10.1097/00004647-199609000-00008	journal	September 1996
Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature Nelson, Peter T.; Alafuzoff, Irina; Bigio, Eileen H. Journal of Neuropathology & Experimental Neurology, Vol. 71, Issue 5 https://doi.org/10.1097/NEN.0b013e31825018f7	journal	May 2012
Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer’s disease Pooler, Amy M.; Polydoro, Manuela; Maury, Eduardo A. Acta Neuropathologica Communications, Vol. 3, Issue 1 https://doi.org/10.1186/s40478-015-0199-x	journal	March 2015
Effects of A immunization (AN1792) on MRI measures of cerebral volume in Alzheimer disease Fox, N. C.; Black, R. S.; Gilman, S. Neurology, Vol. 64, Issue 9 https://doi.org/10.1212/01.WNL.0000159743.08996.99	journal	April 2005
A/T/N: An unbiased descriptive classification scheme for Alzheimer disease biomarkers Jack, Clifford R.; Bennett, David A.; Blennow, Kaj Neurology, Vol. 87, Issue 5 https://doi.org/10.1212/WNL.0000000000002923	journal	July 2016
Entorhinal Tau Pathology, Episodic Memory Decline, and Neurodegeneration in Aging Maass, Anne; Lockhart, Samuel N.; Harrison, Theresa M. The Journal of Neuroscience, Vol. 38, Issue 3 https://doi.org/10.1523/JNEUROSCI.2028-17.2017	journal	November 2017
Aβ Accelerates the Spatiotemporal Progression of Tau Pathology and Augments Tau Amyloidosis in an Alzheimer Mouse Model Hurtado, David E.; Molina-Porcel, Laura; Iba, Michiyo The American Journal of Pathology, Vol. 177, Issue 4 https://doi.org/10.2353/ajpath.2010.100346	journal	October 2010
Reference Tissue–Based Kinetic Evaluation of ¹⁸ F-AV-1451 for Tau Imaging Baker, Suzanne L.; Lockhart, Samuel N.; Price, Julie C. Journal of Nuclear Medicine, Vol. 58, Issue 2 https://doi.org/10.2967/jnumed.116.175273	journal	September 2016

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Distinct effects of beta-amyloid and tau on cortical thickness in cognitively healthy older adults

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