Vascular dysfunction in hemorrhagic viral fevers: opportunities for organotypic modeling

Zarate-Sanchez, Evelyn; George, Steven C.; Moya, Monica L.; Robertson, Claire

doi:10.1088/1758-5090/ad4c0b

Vascular dysfunction in hemorrhagic viral fevers: opportunities for organotypic modeling

Journal Article · Wed Jun 05 00:00:00 EDT 2024 · Biofabrication

DOI:https://doi.org/10.1088/1758-5090/ad4c0b· OSTI ID:2427477

Zarate-Sanchez, Evelyn ^[1]; George, Steven C. ^[1]; Moya, Monica L. ^[2]; ^[3]

University of California, Davis, CA (United States)
Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States); UC Davis Comprehensive Cancer Center, Davis, CA (United States)

The hemorrhagic fever viruses (HFVs) cause severe or fatal infections in humans. Named after their common symptom hemorrhage, these viruses induce significant vascular dysfunction by affecting endothelial cells, altering immunity, and disrupting the clotting system. Despite advances in treatments, such as cytokine blocking therapies, disease modifying treatment for this class of pathogen remains elusive. Improved understanding of the pathogenesis of these infections could provide new avenues to treatment. While animal models and traditional 2D cell cultures have contributed insight into the mechanisms by which these pathogens affect the vasculature, these models fall short in replicating in vivo human vascular dynamics. The emergence of microphysiological systems (MPSs) offers promising avenues for modeling these complex interactions. These MPS or ‘organ-on-chip’ models present opportunities to better mimic human vascular responses and thus aid in treatment development. In this review, we explore the impact of HFV on the vasculature by causing endothelial dysfunction, blood clotting irregularities, and immune dysregulation. We highlight how existing MPS have elucidated features of HFV pathogenesis as well as discuss existing knowledge gaps and the challenges in modeling these interactions using MPS. Understanding the intricate mechanisms of vascular dysfunction caused by HFV is crucial in developing therapies not only for these infections, but also for other vasculotropic conditions like sepsis.

View Accepted Manuscript (DOE)

Research Organization:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

Sponsoring Organization:: National Institutes of Health (NIH); USDOE Laboratory Directed Research and Development (LDRD) Program; USDOE National Nuclear Security Administration (NNSA)

Grant/Contract Number:: AC52-07NA27344

OSTI ID:: 2427477

Report Number(s):: LLNL--JRNL-857781; 1087835

Journal Information:: Biofabrication, Journal Name: Biofabrication Journal Issue: 3 Vol. 16; ISSN 1758-5082

Publisher:: IOP Publishing - International Society of BiofabricationCopyright Statement

Country of Publication:: United States

Language:: English

References (326)

Lassa and mopeia virus replication in human monocytes/macrophages and in endothelial cells: Different effects on IL-8 and TNF-? gene expression Lukashevich, Igor S.; Maryankova, Raisa; Vladyko, Alexander S. Journal of Medical Virology, Vol. 59, Issue 4 https://doi.org/10.1002/(SICI)1096-9071(199912)59:4<552::AID-JMV21>3.0.CO;2-A	journal	December 1999
Pathogenesis of puumala and other hantavirus infections Kanerva, M.; Mustonen, J.; Vaheri, A. Reviews in Medical Virology, Vol. 8, Issue 2 https://doi.org/10.1002/(SICI)1099-1654(199804/06)8:2<67::AID-RMV217>3.0.CO;2-U	journal	April 1998
A Microfluidics‐Based Screening Tool to Assess the Impact of Blood Plasma Factors on Microvascular Integrity Junaid, Abidemi; van Duinen, Vincent; Stam, Wendy Advanced Biology, Vol. 5, Issue 11 https://doi.org/10.1002/adbi.202100954	journal	September 2021
Biomimetic Human Disease Model of SARS‐CoV‐2‐Induced Lung Injury and Immune Responses on Organ Chip System Zhang, Min; Wang, Peng; Luo, Ronghua Advanced Science, Vol. 8, Issue 3 https://doi.org/10.1002/advs.202002928	journal	December 2020
Lassa hemorrhagic shock syndrome‐on‐a‐chip Tang, Huaqi; Abouleila, Yasmine; Mashaghi, Alireza Biotechnology and Bioengineering, Vol. 118, Issue 3 https://doi.org/10.1002/bit.27636	journal	December 2020
SARS‐CoV‐2 cellular tropism and direct multiorgan failure in COVID‐19 patients: Bioinformatic predictions, experimental observations, and open questions Valyaeva, Anna A.; Zharikova, Anastasia A.; Sheval, Eugene V. Cell Biology International, Vol. 47, Issue 2 https://doi.org/10.1002/cbin.11928	journal	October 2022
Organ‐on‐Chip Recapitulates Thrombosis Induced by an anti‐CD154 Monoclonal Antibody: Translational Potential of Advanced Microengineered Systems Barrile, Riccardo; van der Meer, Andries D.; Park, Hyoungshin Clinical Pharmacology & Therapeutics, Vol. 104, Issue 6 https://doi.org/10.1002/cpt.1054	journal	April 2018
Primary Human Lung Alveolus‐on‐a‐chip Model of Intravascular Thrombosis for Assessment of Therapeutics Jain, A.; Barrile, R.; van der Meer, Ad Clinical Pharmacology & Therapeutics, Vol. 103, Issue 2 https://doi.org/10.1002/cpt.742	journal	July 2017
Pathogen interactions with endothelial cells and the induction of innate and adaptive immunity Konradt, Christoph; Hunter, Christopher A. European Journal of Immunology, Vol. 48, Issue 10 https://doi.org/10.1002/eji.201646789	journal	September 2018
Coagulopathy parameters in patients with Crimean-Congo hemorrhagic fever and its relation with mortality Onguru, P.; Dagdas, S.; Bodur, H. Journal of Clinical Laboratory Analysis, Vol. 24, Issue 3 https://doi.org/10.1002/jcla.20383	journal	January 2010
Tissue plasminogen activator induced by dengue virus infection of human endothelial cells Huang, Ying‐Huey; Lei, Huan‐Yao; Liu, Hsiao‐Sheng Journal of Medical Virology, Vol. 70, Issue 4 https://doi.org/10.1002/jmv.10438	journal	June 2003
Hematologic dysfunction in Lassa fever Fisher‐Hoch, Susan P.; McCormick, J. B.; Sasso, D. Journal of Medical Virology, Vol. 26, Issue 2 https://doi.org/10.1002/jmv.1890260204	journal	October 1988
Prognostic impact of platelet distribution width in patients with Crimean-Congo hemorrhagic fever Yilmaz, Hülya; Yilmaz, Gürdal; Menteşe, Ahmet Journal of Medical Virology, Vol. 88, Issue 11 https://doi.org/10.1002/jmv.24547	journal	May 2016
Spike protein mediated membrane fusion during SARS‐CoV‐2 infection Li, Xinyu; Yuan, Huijun; Li, Xiaozhen Journal of Medical Virology, Vol. 95, Issue 1 https://doi.org/10.1002/jmv.28212	journal	October 2022
Ultrastructural pathology of experimental ebola haemorrhagic fever virus infection Baskerville, A.; Fisher‐Hoch, S. P.; Neild, G. H. The Journal of Pathology, Vol. 147, Issue 3 https://doi.org/10.1002/path.1711470308	journal	November 1985
Emerging trends of Nipah virus: A review Sharma, Vikrant; Kaushik, Sulochana; Kumar, Ramesh Reviews in Medical Virology, Vol. 29, Issue 1 https://doi.org/10.1002/rmv.2010	journal	September 2018
Microengineered Human Vein‐Chip Recreates Venous Valve Architecture and Its Contribution to Thrombosis Rajeeva Pandian, Navaneeth Krishna; Walther, Brandon K.; Suresh, Rishi Small, Vol. 16, Issue 49 https://doi.org/10.1002/smll.202003401	journal	November 2020
A Human Vascular Injury‐on‐a‐Chip Model of Hemostasis Poventud‐Fuentes, Izmarie; Kwon, Keon Woo; Seo, Jeongyun Small, Vol. 17, Issue 15 https://doi.org/10.1002/smll.202004889	journal	November 2020
Heparan Sulfate-Mediated Binding of Infectious Dengue Virus Type 2 and Yellow Fever Virus Germi, Raphaële; Crance, Jean-Marc; Garin, Daniel Virology, Vol. 292, Issue 1 https://doi.org/10.1006/viro.2001.1232	journal	January 2002
Role of Monocytes in the Pathogenesis of Dengue Castillo, Jorge Andrés; Naranjo, Juan Sebastián; Rojas, Mauricio Archivum Immunologiae et Therapiae Experimentalis, Vol. 67, Issue 1 https://doi.org/10.1007/s00005-018-0525-7	journal	September 2018
Dengue virus life cycle: viral and host factors modulating infectivity Rodenhuis-Zybert, Izabela A.; Wilschut, Jan; Smit, Jolanda M. Cellular and Molecular Life Sciences, Vol. 67, Issue 16 https://doi.org/10.1007/s00018-010-0357-z	journal	April 2010
Deficiency of coagulation factors is associated with the bleeding diathesis of severe yellow fever Franco, Mariana Brandão; Jardim, Leticia Lemos; de Carvalho, Beatriz Nogueira Annals of Hematology, Vol. 102, Issue 7 https://doi.org/10.1007/s00277-023-05262-x	journal	May 2023
Endothelial cells and coagulation Neubauer, Katharina; Zieger, Barbara Cell and Tissue Research, Vol. 387, Issue 3 https://doi.org/10.1007/s00441-021-03471-2	journal	May 2021
Analysis of the entry mechanism of Crimean-Congo hemorrhagic fever virus, using a vesicular stomatitis virus pseudotyping system Suda, Yuto; Fukushi, Shuetsu; Tani, Hideki Archives of Virology, Vol. 161, Issue 6 https://doi.org/10.1007/s00705-016-2803-1	journal	March 2016
Evaluation of the associations between endothelial dysfunction, inflammation and coagulation in Crimean-Congo hemorrhagic fever patients Doğan, Halef Okan; Büyüktuna, Seyit Ali; Kapancik, Sercan Archives of Virology, Vol. 163, Issue 3 https://doi.org/10.1007/s00705-017-3653-1	journal	November 2017
Factors predicting kidney damage in Puumala virus infected patients in Southern Denmark Skarphedinsson, S.; Thiesson, H. C.; Shakar, S. A. European Journal of Clinical Microbiology & Infectious Diseases, Vol. 34, Issue 10 https://doi.org/10.1007/s10096-015-2446-2	journal	July 2015
Assessment of whole blood thrombosis in a microfluidic device lined by fixed human endothelium Jain, Abhishek; van der Meer, Andries D.; Papa, Anne-Laure Biomedical Microdevices, Vol. 18, Issue 4 https://doi.org/10.1007/s10544-016-0095-6	journal	July 2016
Changes in populations of immune effector cells during the course of haemorrhagic fever with renal syndrome Lewis, Richard M.; Lee, Ho Wang; See, Anthony F. Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol. 85, Issue 2 https://doi.org/10.1016/0035-9203(91)90058-7	journal	January 1991
Hantavirus pulmonary syndrome in the United States: A pathological description of a disease caused by a new agent Nolte, Kurt B.; Feddersen, Richard M.; Foucar, Kathy Human Pathology, Vol. 26, Issue 1 https://doi.org/10.1016/0046-8177(95)90123-X	journal	January 1995
Plasminogen abnormalities in patients with argentine hemorrhagic fever Molinas, Felisa C.; Kordich, Lucia; Porterie, Pablo Thrombosis Research, Vol. 48, Issue 6 https://doi.org/10.1016/0049-3848(87)90436-1	journal	December 1987
Pathogenesis of Ebola Hemorrhagic Fever in Cynomolgus Macaques Geisbert, Thomas W.; Hensley, Lisa E.; Larsen, Tom The American Journal of Pathology, Vol. 163, Issue 6 https://doi.org/10.1016/S0002-9440(10)63591-2	journal	December 2003
Pathogenesis of Ebola Hemorrhagic Fever in Primate Models Geisbert, Thomas W.; Young, Howard A.; Jahrling, Peter B. The American Journal of Pathology, Vol. 163, Issue 6 https://doi.org/10.1016/S0002-9440(10)63592-4	journal	December 2003
Treatment of Ebola virus infection with a recombinant inhibitor of factor VIIa/tissue factor: a study in rhesus monkeys Geisbert, Thomas W.; Hensley, Lisa E.; Jahrling, Peter B. The Lancet, Vol. 362, Issue 9400 https://doi.org/10.1016/S0140-6736(03)15012-X	journal	December 2003
Endothelial cell infection and endotheliitis in COVID-19 Varga, Zsuzsanna; Flammer, Andreas J.; Steiger, Peter The Lancet, Vol. 395, Issue 10234 https://doi.org/10.1016/S0140-6736(20)30937-5	journal	May 2020
Yellow fever: an update Monath, Thomas P. The Lancet Infectious Diseases, Vol. 1, Issue 1 https://doi.org/10.1016/S1473-3099(01)00016-0	journal	August 2001
Clinical and laboratory predictors of Lassa fever outcome in a dedicated treatment facility in Nigeria: a retrospective, observational cohort study Okokhere, Peter; Colubri, Andres; Azubike, Chukwuemeka The Lancet Infectious Diseases, Vol. 18, Issue 6 https://doi.org/10.1016/S1473-3099(18)30121-X	journal	June 2018
Factors associated with progression to death in patients with Lassa fever in Nigeria: an observational study Strampe, Jamie; Asogun, Danny A.; Speranza, Emily The Lancet Infectious Diseases, Vol. 21, Issue 6 https://doi.org/10.1016/S1473-3099(20)30737-4	journal	June 2021
Recognition of decay accelerating factor and αvβ3 by inactivated hantaviruses: Toward the development of high-throughput screening flow cytometry assays Buranda, Tione; Wu, Yang; Perez, Dominique Analytical Biochemistry, Vol. 402, Issue 2 https://doi.org/10.1016/j.ab.2010.03.016	journal	July 2010
Cardiovascular involvement during COVID-19 and clinical implications in elderly patients. A review Napoli, Claudio; Tritto, Isabella; Benincasa, Giuditta Annals of Medicine and Surgery, Vol. 57 https://doi.org/10.1016/j.amsu.2020.07.054	journal	September 2020
Crimean?Congo hemorrhagic fever Whitehouse, C. Antiviral Research, Vol. 64, Issue 3 https://doi.org/10.1016/j.antiviral.2004.08.001	journal	December 2004
Treatment of Argentine hemorrhagic fever Enria, Delia A.; Briggiler, Ana M.; Sánchez, Zaida Antiviral Research, Vol. 78, Issue 1 https://doi.org/10.1016/j.antiviral.2007.10.010	journal	April 2008
Zika, dengue and yellow fever viruses induce differential anti-viral immune responses in human monocytic and first trimester trophoblast cells Luo, Huanle; Winkelmann, Evandro R.; Fernandez-Salas, Ildefonso Antiviral Research, Vol. 151 https://doi.org/10.1016/j.antiviral.2018.01.003	journal	March 2018
Rift Valley fever in animals and humans: Current perspectives McMillen, Cynthia M.; Hartman, Amy L. Antiviral Research, Vol. 156 https://doi.org/10.1016/j.antiviral.2018.05.009	journal	August 2018
Endothelial dysfunction in COVID-19: Current findings and therapeutic implications Nägele, Matthias P.; Haubner, Bernhard; Tanner, Felix C. Atherosclerosis, Vol. 314 https://doi.org/10.1016/j.atherosclerosis.2020.10.014	journal	December 2020
Cellular entry of Hantaan virus A9 strain: Specific interactions with β3 integrins and a novel 70kDa protein Mou, Dan Lei; Wang, Ying Peng; Huang, Chang Xing Biochemical and Biophysical Research Communications, Vol. 339, Issue 2 https://doi.org/10.1016/j.bbrc.2005.11.049	journal	January 2006
Up-regulated expression of β3 integrin induced by dengue virus serotype 2 infection associated with virus entry into human dermal microvascular endothelial cells Zhang, Jun-lei; Wang, Jia-li; Gao, Na Biochemical and Biophysical Research Communications, Vol. 356, Issue 3 https://doi.org/10.1016/j.bbrc.2007.03.051	journal	May 2007
Identification of a putative Crimean-Congo hemorrhagic fever virus entry factor Xiao, Xiaodong; Feng, Yang; Zhu, Zhongyu Biochemical and Biophysical Research Communications, Vol. 411, Issue 2 https://doi.org/10.1016/j.bbrc.2011.06.109	journal	July 2011
Ebola virus: The role of macrophages and dendritic cells in the pathogenesis of Ebola hemorrhagic fever Bray, Mike; Geisbert, Thomas W. The International Journal of Biochemistry & Cell Biology, Vol. 37, Issue 8 https://doi.org/10.1016/j.biocel.2005.02.018	journal	August 2005
Ebola Virus Epidemiology, Transmission, and Evolution during Seven Months in Sierra Leone Park, Daniel J.; Dudas, Gytis; Wohl, Shirlee Cell, Vol. 161, Issue 7 https://doi.org/10.1016/j.cell.2015.06.007	journal	June 2015
Single-Cell Profiling of Ebola Virus Disease In Vivo Reveals Viral and Host Dynamics Kotliar, Dylan; Lin, Aaron E.; Logue, James Cell, Vol. 183, Issue 5 https://doi.org/10.1016/j.cell.2020.10.002	journal	November 2020
Generating human artery and vein cells from pluripotent stem cells highlights the arterial tropism of Nipah and Hendra viruses Ang, Lay Teng; Nguyen, Alana T.; Liu, Kevin J. Cell, Vol. 185, Issue 14 https://doi.org/10.1016/j.cell.2022.05.024	journal	July 2022
Flavivirus NS1 Triggers Tissue-Specific Vascular Endothelial Dysfunction Reflecting Disease Tropism Puerta-Guardo, Henry; Glasner, Dustin R.; Espinosa, Diego A. Cell Reports, Vol. 26, Issue 6 https://doi.org/10.1016/j.celrep.2019.01.036	journal	February 2019
Exhaustion and over-activation of immune cells in COVID-19: Challenges and therapeutic opportunities Alahdal, Murad; Elkord, Eyad Clinical Immunology, Vol. 245 https://doi.org/10.1016/j.clim.2022.109177	journal	December 2022
A prospective prediction tool for understanding Crimean–Congo haemorrhagic fever dynamics in Turkey Ak, Ç.; Ergönül, Ö.; Gönen, M. Clinical Microbiology and Infection, Vol. 26, Issue 1 https://doi.org/10.1016/j.cmi.2019.05.006	journal	January 2020
Ebola Hemorrhagic Shock Syndrome-on-a-Chip Junaid, Abidemi; Tang, Huaqi; van Reeuwijk, Anne iScience, Vol. 23, Issue 1 https://doi.org/10.1016/j.isci.2019.100765	journal	January 2020
Interactions between the innate immune and blood coagulation systems Esmon, Charles T. Trends in Immunology, Vol. 25, Issue 10 https://doi.org/10.1016/j.it.2004.08.003	journal	October 2004
Complement activation in patients with COVID-19: A novel therapeutic target Cugno, Massimo; Meroni, Pier Luigi; Gualtierotti, Roberta Journal of Allergy and Clinical Immunology, Vol. 146, Issue 1 https://doi.org/10.1016/j.jaci.2020.05.006	journal	July 2020
Clinical features and pathobiology of Ebolavirus infection Ansari, Aftab A. Journal of Autoimmunity, Vol. 55 https://doi.org/10.1016/j.jaut.2014.09.001	journal	December 2014
Study of Andes virus entry and neutralization using a pseudovirion system Ray, Neelanjana; Whidby, Jillian; Stewart, Shaun Journal of Virological Methods, Vol. 163, Issue 2 https://doi.org/10.1016/j.jviromet.2009.11.004	journal	February 2010
Hepatic damage caused by flaviviruses: A systematic review Pinheiro, Bruna Santana Silva; Rodrigues, Julia Gonçalves; Dias, Fernanda Carolina Ribeiro Life Sciences, Vol. 331 https://doi.org/10.1016/j.lfs.2023.122074	journal	October 2023
Endothelial glycocalyx degradation during sepsis: Causes and consequences Sullivan, Ryan C.; Rockstrom, Matthew D.; Schmidt, Eric P. Matrix Biology Plus, Vol. 12 https://doi.org/10.1016/j.mbplus.2021.100094	journal	December 2021
Junín virus. A XXI century update Gómez, Ricardo M.; Jaquenod de Giusti, Carolina; Sanchez Vallduvi, Maria M. Microbes and Infection, Vol. 13, Issue 4 https://doi.org/10.1016/j.micinf.2010.12.006	journal	April 2011
SARS-CoV-2 induced intestinal responses with a biomimetic human gut-on-chip Guo, Yaqiong; Luo, Ronghua; Wang, Yaqing Science Bulletin, Vol. 66, Issue 8 https://doi.org/10.1016/j.scib.2020.11.015	journal	April 2021
Global virus outbreaks: Interferons as 1st responders Wang, Ben X.; Fish, Eleanor N. Seminars in Immunology, Vol. 43 https://doi.org/10.1016/j.smim.2019.101300	journal	June 2019
Enhanced thrombin formation and fibrinolysis during acute Puumala hantavirus infection Laine, Outi; Mäkelä, Satu; Mustonen, Jukka Thrombosis Research, Vol. 126, Issue 2 https://doi.org/10.1016/j.thromres.2010.05.025	journal	August 2010
Hemostatic derangement in dengue hemorrhagic fever Chuansumrit, Ampaiwan; Chaiyaratana, Wathanee Thrombosis Research, Vol. 133, Issue 1 https://doi.org/10.1016/j.thromres.2013.09.028	journal	January 2014
D-dimer cut-off points and risk of venous thromboembolism in adult hospitalized patients with COVID-19 Choi, Justin J.; Wehmeyer, Graham T.; Li, Han A. Thrombosis Research, Vol. 196 https://doi.org/10.1016/j.thromres.2020.09.022	journal	December 2020
Human Organs-on-Chips for Virology Tang, Huaqi; Abouleila, Yasmine; Si, Longlong Trends in Microbiology, Vol. 28, Issue 11 https://doi.org/10.1016/j.tim.2020.06.005	journal	November 2020
SARS-CoV-2 and the spike protein in endotheliopathy Perico, Luca; Benigni, Ariela; Remuzzi, Giuseppe Trends in Microbiology, Vol. 32, Issue 1 https://doi.org/10.1016/j.tim.2023.06.004	journal	January 2024
Generation of eGFP expressing recombinant Zaire ebolavirus for analysis of early pathogenesis events and high-throughput antiviral drug screening Towner, Jonathan S.; Paragas, Jason; Dover, Jason E. Virology, Vol. 332, Issue 1 https://doi.org/10.1016/j.virol.2004.10.048	journal	February 2005
Yellow fever virus strains Asibi and 17D-204 infect human umbilical cord endothelial cells and induce novel changes in gene expression Khaiboullina, Svetlana F.; Rizvanov, Albert A.; Holbrook, Michael R. Virology, Vol. 342, Issue 2 https://doi.org/10.1016/j.virol.2005.07.035	journal	November 2005
Crimean Congo hemorrhagic fever virus infects human monocyte-derived dendritic cells Connolly-Andersen, Anne-Marie; Douagi, Iyadh; Kraus, Annette A. Virology, Vol. 390, Issue 2 https://doi.org/10.1016/j.virol.2009.06.010	journal	August 2009
Comparison of three neurotropic viruses reveals differences in viral dissemination to the central nervous system Luethy, Lauren N.; Erickson, Andrea K.; Jesudhasan, Palmy R. Virology, Vol. 487 https://doi.org/10.1016/j.virol.2015.09.019	journal	January 2016
Vascular permeability in the brain is a late pathogenic event during Rift Valley fever virus encephalitis in rats Walters, Aaron W.; Kujawa, Michael R.; Albe, Joseph R. Virology, Vol. 526 https://doi.org/10.1016/j.virol.2018.10.021	journal	January 2019
Adipocytes are susceptible to Ebola Virus infection Gourronc, Francoise A.; Rebagliati, Michael R.; Kramer-Riesberg, Breanna Virology, Vol. 573 https://doi.org/10.1016/j.virol.2022.05.007	journal	August 2022
Increased permeability of human endothelial cell line EA.hy926 induced by hantavirus-specific cytotoxic T lymphocytes Hayasaka, Daisuke; Maeda, Ken; Ennis, Francis A. Virus Research, Vol. 123, Issue 2 https://doi.org/10.1016/j.virusres.2006.08.006	journal	February 2007
Hantavirus pulmonary syndrome MacNeil, Adam; Nichol, Stuart T.; Spiropoulou, Christina F. Virus Research, Vol. 162, Issue 1-2 https://doi.org/10.1016/j.virusres.2011.09.017	journal	December 2011
Coagulation factors, fibrinogen and plasminogen activator inhibitor-1, are differentially regulated by yellow fever virus infection of hepatocytes Woodson, Sara E.; Freiberg, Alexander N.; Holbrook, Michael R. Virus Research, Vol. 175, Issue 2 https://doi.org/10.1016/j.virusres.2013.04.013	journal	August 2013
The role of T reg population in pathogenesis of Crimean Congo hemorrhagic fever Gazi, Umut; Yapar, Derya; Karasartova, Djursun Virus Research, Vol. 250 https://doi.org/10.1016/j.virusres.2018.04.003	journal	May 2018
Dengue virus enters and exits epithelial cells through both apical and basolateral surfaces and perturbs the apical junctional complex Ramirez, Liliana; Betanzos, Abigail; Raya-Sandino, Arturo Virus Research, Vol. 258 https://doi.org/10.1016/j.virusres.2018.09.016	journal	October 2018
Bioinspired Microfluidic Assay for In Vitro Modeling of Leukocyte–Endothelium Interactions Lamberti, Giuseppina; Prabhakarpandian, Balabhaskar; Garson, Charles Analytical Chemistry, Vol. 86, Issue 16 https://doi.org/10.1021/ac5018716	journal	July 2014
Analysis of an Integrated Human Multiorgan Microphysiological System for Combined Tolcapone Metabolism and Brain Metabolomics Wang, Xin; Cirit, Murat; Wishnok, John S. Analytical Chemistry, Vol. 91, Issue 13 https://doi.org/10.1021/acs.analchem.9b02224	journal	June 2019
Molecular mechanisms of Ebola virus pathogenesis: focus on cell death Falasca, L.; Agrati, C.; Petrosillo, N. Cell Death & Differentiation, Vol. 22, Issue 8 https://doi.org/10.1038/cdd.2015.67	journal	May 2015
Apoptosis Induced In Vitro and In Vivo During Infection by Ebola and Marburg Viruses Geisbert, Thomas W.; Hensley, Lisa E.; Gibb, Tammy R. Laboratory Investigation, Vol. 80, Issue 2 https://doi.org/10.1038/labinvest.3780021	journal	February 2000
EphrinB2 is the entry receptor for Nipah virus, an emergent deadly paramyxovirus Negrete, Oscar A.; Levroney, Ernest L.; Aguilar, Hector C. Nature, Vol. 436, Issue 7049 https://doi.org/10.1038/nature03838	journal	July 2005
Unique human immune signature of Ebola virus disease in Guinea Ruibal, Paula; Oestereich, Lisa; Lüdtke, Anja Nature, Vol. 533, Issue 7601 https://doi.org/10.1038/nature17949	journal	May 2016
Microfluidic organs-on-chips Bhatia, Sangeeta N.; Ingber, Donald E. Nature Biotechnology, Vol. 32, Issue 8 https://doi.org/10.1038/nbt.2989	journal	August 2014
Original antigenic sin and apoptosis in the pathogenesis of dengue hemorrhagic fever Mongkolsapaya, Juthathip; Dejnirattisai, Wanwisa; Xu, Xiao-ning Nature Medicine, Vol. 9, Issue 7 https://doi.org/10.1038/nm887	journal	June 2003
Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro Benam, Kambez H.; Villenave, Remi; Lucchesi, Carolina Nature Methods, Vol. 13, Issue 2 https://doi.org/10.1038/nmeth.3697	journal	December 2015
Immunobiology of Ebola and Lassa virus infections Prescott, Joseph B.; Marzi, Andrea; Safronetz, David Nature Reviews Immunology, Vol. 17, Issue 3 https://doi.org/10.1038/nri.2016.138	journal	January 2017
Evolving functions of endothelial cells in inflammation Pober, Jordan S.; Sessa, William C. Nature Reviews Immunology, Vol. 7, Issue 10 https://doi.org/10.1038/nri2171	journal	October 2007
Vascular heterogeneity and specialization in development and disease Potente, Michael; Mäkinen, Taija Nature Reviews Molecular Cell Biology, Vol. 18, Issue 8 https://doi.org/10.1038/nrm.2017.36	journal	May 2017
Endothelial cell–cell junctions: happy together Dejana, Elisabetta Nature Reviews Molecular Cell Biology, Vol. 5, Issue 4 https://doi.org/10.1038/nrm1357	journal	April 2004
Uncovering the mysteries of hantavirus infections Vaheri, Antti; Strandin, Tomas; Hepojoki, Jussi Nature Reviews Microbiology, Vol. 11, Issue 8 https://doi.org/10.1038/nrmicro3066	journal	July 2013
Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection Pérez-Gómez, Alberto; Vitallé, Joana; Gasca-Capote, Carmen Cellular & Molecular Immunology, Vol. 18, Issue 9 https://doi.org/10.1038/s41423-021-00728-2	journal	July 2021
Kyasanur Forest disease virus infection activates human vascular endothelial cells and monocyte-derived dendritic cells Sirmarova, Jana; Salat, Jiri; Palus, Martin Emerging Microbes & Infections, Vol. 7, Issue 1 https://doi.org/10.1038/s41426-018-0177-z	journal	November 2018
SARS-CoV-2 Spike triggers barrier dysfunction and vascular leak via integrins and TGF-β signaling Biering, Scott B.; Gomes de Sousa, Francielle Tramontini; Tjang, Laurentia V. Nature Communications, Vol. 13, Issue 1 https://doi.org/10.1038/s41467-022-34910-5	journal	December 2022
A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics Si, Longlong; Bai, Haiqing; Rodas, Melissa Nature Biomedical Engineering, Vol. 5, Issue 8 https://doi.org/10.1038/s41551-021-00718-9	journal	May 2021
Human organs-on-chips for disease modelling, drug development and personalized medicine Ingber, Donald E. Nature Reviews Genetics, Vol. 23, Issue 8 https://doi.org/10.1038/s41576-022-00466-9	journal	March 2022
Immunomodulation by endothelial cells — partnering up with the immune system? Amersfoort, Jacob; Eelen, Guy; Carmeliet, Peter Nature Reviews Immunology, Vol. 22, Issue 9 https://doi.org/10.1038/s41577-022-00694-4	journal	March 2022
Immunity, endothelial injury and complement-induced coagulopathy in COVID-19 Perico, Luca; Benigni, Ariela; Casiraghi, Federica Nature Reviews Nephrology, Vol. 17, Issue 1 https://doi.org/10.1038/s41581-020-00357-4	journal	October 2020
Protocadherin-1 is essential for cell entry by New World hantaviruses Jangra, Rohit K.; Herbert, Andrew S.; Li, Rong Nature, Vol. 563, Issue 7732 https://doi.org/10.1038/s41586-018-0702-1	journal	November 2018
Efficient engineering of human and mouse primary cells using peptide-assisted genome editing Zhang, Zhen; Baxter, Amy E.; Ren, Diqiu Nature Biotechnology, Vol. 42, Issue 2 https://doi.org/10.1038/s41587-023-01756-1	journal	April 2023
A prolonged innate systemic immune response in COVID-19 Ekstedt, Sandra; Piersiala, Krzysztof; Petro, Marianne Scientific Reports, Vol. 12, Issue 1 https://doi.org/10.1038/s41598-022-13986-5	journal	June 2022
HTNV infection of CD8+ T cells is associated with disease progression in HFRS patients Liu, Rongrong; Ma, Ruixue; Liu, Ziyu Communications Biology, Vol. 4, Issue 1 https://doi.org/10.1038/s42003-021-02182-2	journal	June 2021
A guide to the organ-on-a-chip Leung, Chak Ming; de Haan, Pim; Ronaldson-Bouchard, Kacey Nature Reviews Methods Primers, Vol. 2, Issue 1 https://doi.org/10.1038/s43586-022-00118-6	journal	May 2022
Dengue‐virus‐infected dendritic cells trigger vascular leakage through metalloproteinase overproduction Luplerdlop, Natthanej; Missé, Dorothée; Bray, Dorothy EMBO reports, Vol. 7, Issue 11 https://doi.org/10.1038/sj.embor.7400814	journal	October 2006
Bioprinted thrombosis-on-a-chip Zhang, Yu Shrike; Davoudi, Farideh; Walch, Philipp Lab on a Chip, Vol. 16, Issue 21 https://doi.org/10.1039/C6LC00380J	journal	January 2016
Mimicking arterial thrombosis in a 3D-printed microfluidic in vitro vascular model based on computed tomography angiography data Costa, Pedro F.; Albers, Hugo J.; Linssen, John E. A. Lab on a Chip, Vol. 17, Issue 16 https://doi.org/10.1039/C7LC00202E	journal	January 2017
Effective bioprinting resolution in tissue model fabrication Miri, Amir K.; Mirzaee, Iman; Hassan, Shabir Lab on a Chip, Vol. 19, Issue 11 https://doi.org/10.1039/C8LC01037D	journal	January 2019
Organ-on-chips made of blood: endothelial progenitor cells from blood reconstitute vascular thromboinflammation in vessel-chips Mathur, Tanmay; Singh, Kanwar Abhay; R. Pandian, Navaneeth K. Lab on a Chip, Vol. 19, Issue 15 https://doi.org/10.1039/C9LC00469F	journal	January 2019
An “occlusive thrombosis-on-a-chip” microfluidic device for investigating the effect of anti-thrombotic drugs Berry, Jess; Peaudecerf, François J.; Masters, Nicole A. Lab on a Chip, Vol. 21, Issue 21 https://doi.org/10.1039/D1LC00347J	journal	January 2021
Vasculature-on-a-chip platform with innate immunity enables identification of angiopoietin-1 derived peptide as a therapeutic for SARS-CoV-2 induced inflammation Lu, Rick Xing Ze; Lai, Benjamin Fook Lun; Rafatian, Naimeh Lab on a Chip, Vol. 22, Issue 6 https://doi.org/10.1039/D1LC00817J	journal	January 2022
Haematological, Biochemical and Coagulation Changes in Mice, Guinea-pigs and Monkeys Infected with a Mouse-adapted Variant of Ebola Zaire Virus Bray, M.; Hatfill, S.; Hensley, L. Journal of Comparative Pathology, Vol. 125, Issue 4 https://doi.org/10.1053/jcpa.2001.0503	journal	November 2001
D-dimer is Associated with Severity of Coronavirus Disease 2019: A Pooled Analysis Lippi, Giuseppe; Favaloro, Emmanuel J. Thrombosis and Haemostasis, Vol. 120, Issue 05 https://doi.org/10.1055/s-0040-1709650	journal	April 2020
Argentine Hemorrhagic Fever de Bracco, María M. E.; Rimoldi, María T.; Cossio, Patricío M. New England Journal of Medicine, Vol. 299, Issue 5 https://doi.org/10.1056/NEJM197808032990502	journal	August 1978
A tunable microfluidic 3D stenosis model to study leukocyte-endothelial interactions in atherosclerosis Venugopal Menon, Nishanth; Tay, Hui Min; Pang, Kuin Tian APL Bioengineering, Vol. 2, Issue 1 https://doi.org/10.1063/1.4993762	journal	March 2018
From The Cover: Ephrin-B2 ligand is a functional receptor for Hendra virus and Nipah virus Bonaparte, M. I.; Dimitrov, A. S.; Bossart, K. N. Proceedings of the National Academy of Sciences, Vol. 102, Issue 30 https://doi.org/10.1073/pnas.0504887102	journal	July 2005
In vitro microvessels for the study of angiogenesis and thrombosis Zheng, Y.; Chen, J.; Craven, M. Proceedings of the National Academy of Sciences, Vol. 109, Issue 24 https://doi.org/10.1073/pnas.1201240109	journal	May 2012
Type I interferon is a therapeutic target for virus-induced lethal vascular damage Baccala, Roberto; Welch, Megan J.; Gonzalez-Quintial, Rosana Proceedings of the National Academy of Sciences, Vol. 111, Issue 24 https://doi.org/10.1073/pnas.1408148111	journal	June 2014
Pathogenic and nonpathogenic hantaviruses differentially regulate endothelial cell responses Geimonen, Erika; Neff, Sherry; Raymond, Tracy Proceedings of the National Academy of Sciences, Vol. 99, Issue 21 https://doi.org/10.1073/pnas.192298899	journal	October 2002
Consumptive coagulopathy of severe yellow fever occurs independently of hepatocellular tropism and massive hepatic injury Bailey, Adam L.; Kang, Liang-I; de Assis Barros D’Elia Zanella, Luiz Gonzaga Francisco Proceedings of the National Academy of Sciences, Vol. 117, Issue 51 https://doi.org/10.1073/pnas.2014096117	journal	December 2020
The Ebola virus VP35 protein functions as a type I IFN antagonist Basler, C. F.; Wang, X.; Muhlberger, E. Proceedings of the National Academy of Sciences, Vol. 97, Issue 22 https://doi.org/10.1073/pnas.220398297	journal	October 2000
3 integrins mediate the cellular entry of hantaviruses that cause respiratory failure Gavrilovskaya, I. N.; Shepley, M.; Shaw, R. Proceedings of the National Academy of Sciences, Vol. 95, Issue 12 https://doi.org/10.1073/pnas.95.12.7074	journal	June 1998
Platelet-derived Growth Factor Receptor β and Vascular Endothelial Growth Factor Receptor 2 Bind to the β3Integrin through Its Extracellular Domain Borges, Eric; Jan, Yiwen; Ruoslahti, Erkki Journal of Biological Chemistry, Vol. 275, Issue 51 https://doi.org/10.1074/jbc.M007040200	journal	December 2000
Lassa Virus Günther, Stephan; Lenz, Oliver Critical Reviews in Clinical Laboratory Sciences, Vol. 41, Issue 4 https://doi.org/10.1080/10408360490497456	journal	January 2004
Kidney disease in Puumala hantavirus infection Mustonen, Jukka; Outinen, Tuula; Laine, Outi Infectious Diseases, Vol. 49, Issue 5 https://doi.org/10.1080/23744235.2016.1274421	journal	January 2017
Post-infectious fatigue following Puumala virus infection Furberg, Maria; Anticona, Cynthia; Schumann, Barbara Infectious Diseases, Vol. 51, Issue 7 https://doi.org/10.1080/23744235.2019.1605191	journal	May 2019
Rapid expansion and long-term persistence of elevated NK cell numbers in humans infected with hantavirus Björkström, Niklas K.; Lindgren, Therese; Stoltz, Malin Journal of Experimental Medicine, Vol. 208, Issue 1 https://doi.org/10.1084/jem.20100762	journal	December 2010
Hantavirus Pulmonary Syndrome: The New American Hemorrhagic Fever Peters, C. J.; Khan, Ali S. Clinical Infectious Diseases, Vol. 34, Issue 9 https://doi.org/10.1086/339864	journal	May 2002
Coagulation Abnormalities in Dengue Hemorrhagic Fever: Serial Investigations in 167 Vietnamese Children with Dengue Shock Syndrome Wills, Bridget A.; Oragui, Emmanuelle E.; Stephens, Alick C. Clinical Infectious Diseases, Vol. 35, Issue 3 https://doi.org/10.1086/341410	journal	August 2002
Rift Valley Fever Epidemic in Saudi Arabia: Epidemiological, Clinical, and Laboratory Characteristics Madani, T. A.; Al-Mazrou, Y. Y.; Al-Jeffri, M. H. Clinical Infectious Diseases, Vol. 37, Issue 8 https://doi.org/10.1086/378747	journal	October 2003
Ebola and Marburg Viruses Replicate in Monocyte‐Derived Dendritic Cells without Inducing the Production of Cytokines and Full Maturation Bosio, Catharine M.; Aman, M. Javad; Grogan, Case The Journal of Infectious Diseases, Vol. 188, Issue 11 https://doi.org/10.1086/379199	journal	December 2003
Mechanisms Underlying Coagulation Abnormalities in Ebola Hemorrhagic Fever: Overexpression of Tissue Factor in Primate Monocytes/Macrophages Is a Key Event Geisbert, Thomas W.; Young, Howard A.; Jahrling, Peter B. The Journal of Infectious Diseases, Vol. 188, Issue 11 https://doi.org/10.1086/379724	journal	December 2003
Ebola Hemorrhagic Fever and Septic Shock Bray, Mike; Mahanty, Siddhartha The Journal of Infectious Diseases, Vol. 188, Issue 11 https://doi.org/10.1086/379727	journal	December 2003
Localization of Dengue Virus in Naturally Infected Human Tissues, by Immunohistochemistry and In Situ Hybridization Jessie, Kala; Fong, Mun Yik; Devi, Shamala The Journal of Infectious Diseases, Vol. 189, Issue 8 https://doi.org/10.1086/383043	journal	April 2004
Activation of the Cytokine Network and Unfavorable Outcome in Patients with Yellow Fever ter Meulen, Jan; Sakho, Mohamed; Koulemou, Kekoura The Journal of Infectious Diseases, Vol. 190, Issue 10 https://doi.org/10.1086/425016	journal	November 2004
Sin Nombre Viral RNA Load in Patients with Hantavirus Cardiopulmonary Syndrome Xiao, Ruobing; Yang, Shu; Koster, Fred The Journal of Infectious Diseases, Vol. 194, Issue 10, p. 1403-1409 https://doi.org/10.1086/508494	journal	November 2006
Protective Efficacy of a Live Attenuated Vaccine against Argentine Hemorrhagic Fever Maiztegui, Julio I.; McKee, Jr., Kelly T.; Oro, Julio G. Barrera The Journal of Infectious Diseases, Vol. 177, Issue 2 https://doi.org/10.1086/514211	journal	February 1998
Markedly Elevated Levels of Interferon (IFN)‐σ, IFN‐α, Interleukin (IL)‐2, IL‐10, and Tumor Necrosis Factor‐α Associated with Fatal Ebola Virus Infection Villinger, Francois; Rollin, Pierre E.; Brar, Sukhdev S. The Journal of Infectious Diseases, Vol. 179, Issue s1 https://doi.org/10.1086/514283	journal	February 1999
Clinical Case Definitions for Argentine Hemorrhagic Fever Harrison, Lee H.; Halsey, Neal A.; McKee, Jr., Kelly T. Clinical Infectious Diseases, Vol. 28, Issue 5 https://doi.org/10.1086/514749	journal	May 1999
Breakdown of Paraendothelial Barrier Function during Marburg Virus Infection Is Associated with Early Tyrosine Phosphorylation of Platelet Endothelial Cell Adhesion Molecule–1 Böckeler, Michael; Ströher, Ute; Seebach, Jochen The Journal of Infectious Diseases, Vol. 196, Issue s2 https://doi.org/10.1086/520606	journal	November 2007
Recapitulating atherogenic flow disturbances and vascular inflammation in a perfusable 3D stenosis model Menon, Nishanth Venugopal; Su, Chengxun; Pang, Kuin Tian Biofabrication, Vol. 12, Issue 4 https://doi.org/10.1088/1758-5090/aba501	journal	August 2020
Correlation Between Endogenous Interferon and the Clinical Evolution of Patients with Argentine Hemorrhagic Fever Levis, Silvana C.; Saavedra, MarÍA C.; Ceccoli, Cristina Journal of Interferon Research, Vol. 5, Issue 3 https://doi.org/10.1089/jir.1985.5.383	journal	January 1985
Depletion of Peripheral Blood T Lymphocytes and NK Cells During the Course of Ebola Hemorrhagic Fever in Cynomolgus Macaques Reed, Douglas S.; Hensley, Lisa E.; Geisbert, Joan B. Viral Immunology, Vol. 17, Issue 3 https://doi.org/10.1089/vim.2004.17.390	journal	September 2004
Ebola Virus Infection Induces Irregular Dendritic Cell Gene Expression Melanson, Vanessa R.; Kalina, Warren V.; Williams, Priscilla Viral Immunology, Vol. 28, Issue 1 https://doi.org/10.1089/vim.2014.0091	journal	February 2015
Pathology and Pathogenesis of Lassa Fever: Novel Immunohistochemical Findings in Fatal Cases and Clinico-pathologic Correlation Shieh, Wun-Ju; Demby, Austin; Jones, Tara Clinical Infectious Diseases, Vol. 74, Issue 10 https://doi.org/10.1093/cid/ciab719	journal	August 2021
Kinetic Analysis of Biomarkers in a Cohort of US Patients With Ebola Virus Disease McElroy, Anita K.; Harmon, Jessica R.; Flietstra, Timothy D. Clinical Infectious Diseases, Vol. 63, Issue 4 https://doi.org/10.1093/cid/ciw334	journal	June 2016
The Clinical Pathology of Crimean-Congo Hemorrhagic Fever Swanepoel, R.; Gill, D. E.; Shepherd, A. J. Clinical Infectious Diseases, Vol. 11, Issue Supplement_4 https://doi.org/10.1093/clinids/11.Supplement_4.S794	journal	May 1989
Physiological and Immunologic Disturbances Associated with Shock in a Primate Model of Lassa Fever Fisher-Hoch, S. P.; Mitchell, S. W.; Sasso, D. R. Journal of Infectious Diseases, Vol. 155, Issue 3 https://doi.org/10.1093/infdis/155.3.465	journal	March 1987
Abnormalities of T Cell Immunoregulation in Hemorrhagic Fever with Renal Syndrome Chen, L.; Yang, W. Journal of Infectious Diseases, Vol. 161, Issue 5 https://doi.org/10.1093/infdis/161.5.1016	journal	May 1990
Elevated Plasma Levels of Tumor Necrosis Factor (TNF)-α, Soluble TNF Receptors, Interleukin (IL)-6, and IL-IO in Patients with Hemorrhagic Fever with Renal Syndrome Linderholm, Mats; Ahlm, Clas; Settergren, Bo The Journal of Infectious Diseases, Vol. 173, Issue 1 https://doi.org/10.1093/infdis/173.1.38	journal	January 1996
Hantavirus Pulmonary Syndrome: The First 100 US Cases Khan, A. S.; Khabbaz, R. F.; Armstrong, L. R. Journal of Infectious Diseases, Vol. 173, Issue 6 https://doi.org/10.1093/infdis/173.6.1297	journal	June 1996
Basic Clinical and Laboratory Features of Filoviral Hemorrhagic Fever Kortepeter, Mark G.; Bausch, Daniel G.; Bray, Mike The Journal of Infectious Diseases, Vol. 204, Issue suppl_3 https://doi.org/10.1093/infdis/jir299	journal	November 2011
Ebola Virus Enters Host Cells by Macropinocytosis and Clathrin-Mediated Endocytosis Aleksandrowicz, Paulina; Marzi, Andrea; Biedenkopf, Nadine The Journal of Infectious Diseases, Vol. 204, Issue suppl_3 https://doi.org/10.1093/infdis/jir326	journal	November 2011
Ebola Hemorrhagic Fever: Novel Biomarker Correlates of Clinical Outcome McElroy, A. K.; Erickson, B. R.; Flietstra, T. D. Journal of Infectious Diseases, Vol. 210, Issue 4 https://doi.org/10.1093/infdis/jiu088	journal	February 2014
Increased Thrombopoiesis and Platelet Activation in Hantavirus-Infected Patients Connolly-Andersen, Anne-Marie; Sundberg, Erik; Ahlm, Clas Journal of Infectious Diseases, Vol. 212, Issue 7 https://doi.org/10.1093/infdis/jiv161	journal	March 2015
Considerations in the Use of Nonhuman Primate Models of Ebola Virus and Marburg Virus Infection: Table 1. Geisbert, Thomas W.; Strong, James E.; Feldmann, Heinz Journal of Infectious Diseases, Vol. 212, Issue suppl 2 https://doi.org/10.1093/infdis/jiv284	journal	June 2015
Severity of Plasma Leakage Is Associated With High Levels of Interferon γ–Inducible Protein 10, Hepatocyte Growth Factor, Matrix Metalloproteinase 2 (MMP-2), and MMP-9 During Dengue Virus Infection Her, Zhisheng; Kam, Yiu-Wing; Gan, Victor C. Journal of Infectious Diseases, Vol. 215, Issue 1 https://doi.org/10.1093/infdis/jiw494	journal	October 2016
Association of Endothelial Glycocalyx and Tight and Adherens Junctions with Severity of Plasma Leakage in Dengue Infection Suwarto, Suhendro; Tedjo Sasmono, R.; Sinto, Robert The Journal of Infectious Diseases https://doi.org/10.1093/infdis/jix041	journal	February 2017
Delayed Interferon Type 1-Induced Antiviral State Is a Potential Factor for Hemorrhagic Fever With Renal Syndrome Severity Resman Rus, Katarina; Korva, Miša; Bogovič, Petra The Journal of Infectious Diseases, Vol. 217, Issue 6 https://doi.org/10.1093/infdis/jix650	journal	December 2017
Human Biomarkers of Outcome Following Rift Valley Fever Virus Infection McElroy, Anita K.; Harmon, Jessica R.; Flietstra, Timothy The Journal of Infectious Diseases, Vol. 218, Issue 11 https://doi.org/10.1093/infdis/jiy393	journal	June 2018
Kinetics of Soluble Mediators of the Host Response in Ebola Virus Disease Kerber, Romy; Krumkamp, Ralf; Korva, Misa The Journal of Infectious Diseases, Vol. 218, Issue suppl_5 https://doi.org/10.1093/infdis/jiy429	journal	August 2018
Circulating Extracellular Vesicle Tissue Factor Activity During Orthohantavirus Infection Is Associated With Intravascular Coagulation Schmedes, Clare M.; Grover, Steven P.; Hisada, Yohei M. The Journal of Infectious Diseases, Vol. 222, Issue 8 https://doi.org/10.1093/infdis/jiz597	journal	November 2019
Severe yellow fever in Brazil: clinical characteristics and management Ho, Yeh-Li; Joelsons, Daniel; Leite, Gabriel F. C. Journal of Travel Medicine, Vol. 26, Issue 5 https://doi.org/10.1093/jtm/taz040	journal	May 2019
Natural History of Plasma Leakage in Dengue Hemorrhagic Fever Srikiatkhachorn, Anon; Krautrachue, Anchalee; Ratanaprakarn, Warangkana Pediatric Infectious Disease Journal, Vol. 26, Issue 4 https://doi.org/10.1097/01.inf.0000258612.26743.10	journal	April 2007
Alteration of Cytokines and Chemokines During Febrile Episodes Associated With Endothelial Cell Damage and Plasma Leakage in Dengue Hemorrhagic Fever Butthep, Punnee; Chunhakan, Sirichan; Yoksan, Sutee Pediatric Infectious Disease Journal, Vol. 31, Issue 12 https://doi.org/10.1097/INF.0b013e31826fd456	journal	December 2012
Manifestation of thrombocytopenia in dengue-2-virus-infected mice Huang, Kao-Jean; Li, Shu-Yi J.; Chen, Shiour-Ching Journal of General Virology, Vol. 81, Issue 9 https://doi.org/10.1099/0022-1317-81-9-2177	journal	September 2000
Rift Valley fever: biology and epidemiology Wright, Daniel; Kortekaas, Jeroen; Bowden, Thomas A. Journal of General Virology, Vol. 100, Issue 8 https://doi.org/10.1099/jgv.0.001296	journal	August 2019
IL8 release, tight junction and cytoskeleton dynamic reorganization conducive to permeability increase are induced by dengue virus infection of microvascular endothelial monolayers Talavera, Dodanim; Castillo, Aida M.; Dominguez, M. C. Journal of General Virology, Vol. 85, Issue 7 https://doi.org/10.1099/vir.0.19652-0	journal	July 2004
MCP-1, a highly expressed chemokine in dengue haemorrhagic fever/dengue shock syndrome patients, may cause permeability change, possibly through reduced tight junctions of vascular endothelium cells Lee, Ying-Ray; Liu, Ming-Tao; Lei, Huan-Yao Journal of General Virology, Vol. 87, Issue 12 https://doi.org/10.1099/vir.0.82093-0	journal	December 2006
Resistance of endothelial cells to SARS-CoV-2 infection in vitro Ahmetaj-Shala, Blerina; Peacock, Thomas P.; Baillon, Laury https://doi.org/10.1101/2020.11.08.372581	posted_content	November 2020
Association between ABO blood groups and risk of SARS‐CoV‐2 pneumonia Li, Juyi; Wang, Xiufang; Chen, Jian British Journal of Haematology, Vol. 190, Issue 1 https://doi.org/10.1111/bjh.16797	journal	May 2020
The Original Haernorrhagic Fever: Yellow Fever Dennis, Lewis H.; Reisberg, Boris E.; Crosbie, James British Journal of Haematology, Vol. 17, Issue 5 https://doi.org/10.1111/j.1365-2141.1969.tb01393.x	journal	November 1969
A plasma inhibitor of platelet aggregation in patients with Lassa fever Cummins, David; Fisher‐Hoch, Susan P.; Walshe, Karen J. British Journal of Haematology, Vol. 72, Issue 4 https://doi.org/10.1111/j.1365-2141.1989.tb04321.x	journal	August 1989
Guidelines for the diagnosis and management of disseminated intravascular coagulation Levi, M.; Toh, C. H.; Thachil, J. British Journal of Haematology, Vol. 145, Issue 1 https://doi.org/10.1111/j.1365-2141.2009.07600.x	journal	March 2009
Denguevirus-specific suppressor T cells: current perspectives Chaturvedi, Umesh C.; Shrivastava, Richa; Tripathi, Raj K. FEMS Immunology & Medical Microbiology, Vol. 50, Issue 3 https://doi.org/10.1111/j.1574-695X.2007.00273.x	journal	August 2007
Vascular endothelium: the battlefield of dengue viruses Basu, Atanu; Chaturvedi, Umesh C. FEMS Immunology & Medical Microbiology, Vol. 53, Issue 3 https://doi.org/10.1111/j.1574-695X.2008.00420.x	journal	August 2008
Localized endothelial‐based control of platelet aggregation and coagulation under flow: A proof‐of‐principle vessel‐on‐a‐chip study Brouns, Sanne L. N.; Provenzale, Isabella; van Geffen, Johanna P. Journal of Thrombosis and Haemostasis, Vol. 18, Issue 4 https://doi.org/10.1111/jth.14719	journal	April 2020
Identification of α-Dystroglycan as a Receptor for Lymphocytic Choriomeningitis Virus and Lassa Fever Virus Cao, Wei; Henry, Michael D.; Borrow, Persephone Science, Vol. 282, Issue 5396 https://doi.org/10.1126/science.282.5396.2079	journal	December 1998
Dengue subgenomic RNA binds TRIM25 to inhibit interferon expression for epidemiological fitness Manokaran, G.; Finol, E.; Wang, C. Science, Vol. 350, Issue 6257 https://doi.org/10.1126/science.aab3369	journal	July 2015
Dengue and Dengue Hemorrhagic Fever Gubler, Duane J. Clinical Microbiology Reviews, Vol. 11, Issue 3 https://doi.org/10.1128/CMR.11.3.480	journal	July 1998
Interacting Roles of Immune Mechanisms and Viral Load in the Pathogenesis of Crimean-Congo Hemorrhagic Fever Saksida, A.; Duh, D.; Wraber, B. Clinical and Vaccine Immunology, Vol. 17, Issue 7 https://doi.org/10.1128/CVI.00530-09	journal	May 2010
Puumala Hantavirus Viremia Diagnosed by Real-Time Reverse Transcriptase PCR Using Samples from Patients with Hemorrhagic Fever and Renal Syndrome Evander, Magnus; Eriksson, Irene; Pettersson, Lisa Journal of Clinical Microbiology, Vol. 45, Issue 8 https://doi.org/10.1128/JCM.01902-06	journal	August 2007
Lassa Virus Cell Entry via Dystroglycan Involves an Unusual Pathway of Macropinocytosis Oppliger, Joel; Torriani, Giulia; Herrador, Antonio Journal of Virology, Vol. 90, Issue 14 https://doi.org/10.1128/JVI.00257-16	journal	May 2016
Rift Valley Fever Virus Clearance and Protection from Neurologic Disease Are Dependent on CD4 ⁺ T Cell and Virus-Specific Antibody Responses Dodd, Kimberly A.; McElroy, Anita K.; Jones, Megan E. B. Journal of Virology, Vol. 87, Issue 11 https://doi.org/10.1128/JVI.00337-13	journal	June 2013
Highly Pathogenic New World and Old World Human Arenaviruses Induce Distinct Interferon Responses in Human Cells Huang, Cheng; Kolokoltsova, Olga A.; Yun, Nadezhda E. Journal of Virology, Vol. 89, Issue 14 https://doi.org/10.1128/JVI.00526-15	journal	July 2015
Pathogenic Old World Hantaviruses Infect Renal Glomerular and Tubular Cells and Induce Disassembling of Cell-to-Cell Contacts Krautkrämer, Ellen; Grouls, Stephan; Stein, Nadine Journal of Virology, Vol. 85, Issue 19 https://doi.org/10.1128/JVI.00568-11	journal	October 2011
Pathogenic Hantaviruses Andes Virus and Hantaan Virus Induce Adherens Junction Disassembly by Directing Vascular Endothelial Cadherin Internalization in Human Endothelial Cells Gorbunova, Elena; Gavrilovskaya, Irina N.; Mackow, Erich R. Journal of Virology, Vol. 84, Issue 14 https://doi.org/10.1128/JVI.00576-10	journal	July 2010
Differential Inhibition of Type I Interferon Induction by Arenavirus Nucleoproteins Martínez-Sobrido, Luis; Giannakas, Panagiotis; Cubitt, Beatrice Journal of Virology, Vol. 81, Issue 22 https://doi.org/10.1128/JVI.00882-07	journal	September 2007
Z Proteins of New World Arenaviruses Bind RIG-I and Interfere with Type I Interferon Induction Fan, Lina; Briese, Thomas; Lipkin, W. Ian Journal of Virology, Vol. 84, Issue 4 https://doi.org/10.1128/JVI.01362-09	journal	December 2009
Heparan Sulfate Facilitates Rift Valley Fever Virus Entry into the Cell de Boer, S. M.; Kortekaas, J.; de Haan, C. A. M. Journal of Virology, Vol. 86, Issue 24 https://doi.org/10.1128/JVI.01364-12	journal	December 2012
Severe Human Lassa Fever Is Characterized by Nonspecific T-Cell Activation and Lymphocyte Homing to Inflamed Tissues Port, Julia R.; Wozniak, David M.; Oestereich, Lisa Journal of Virology, Vol. 94, Issue 21 https://doi.org/10.1128/JVI.01367-20	journal	October 2020
Andes Virus Disrupts the Endothelial Cell Barrier by Induction of Vascular Endothelial Growth Factor and Downregulation of VE-Cadherin Shrivastava-Ranjan, Punya; Rollin, Pierre E.; Spiropoulou, Christina F. Journal of Virology, Vol. 84, Issue 21 https://doi.org/10.1128/JVI.01405-10	journal	November 2010
Virus-Induced Decline in Soluble Vascular Endothelial Growth Receptor 2 Is Associated with Plasma Leakage in Dengue Hemorrhagic Fever Srikiatkhachorn, Anon; Ajariyakhajorn, Chuanpis; Endy, Timothy P. Journal of Virology, Vol. 81, Issue 4 https://doi.org/10.1128/JVI.01642-06	journal	February 2007
Basolateral Entry and Release of Crimean-Congo Hemorrhagic Fever Virus in Polarized MDCK-1 Cells Connolly-Andersen, A. -M.; Magnusson, K. -E.; Mirazimi, A. Journal of Virology, Vol. 81, Issue 5 https://doi.org/10.1128/JVI.02070-06	journal	December 2006
Human Dendritic Cells Infected with the Nonpathogenic Mopeia Virus Induce Stronger T-Cell Responses than Those Infected with Lassa Virus Pannetier, Delphine; Reynard, Stéphanie; Russier, Marion Journal of Virology, Vol. 85, Issue 16 https://doi.org/10.1128/JVI.02120-10	journal	August 2011
Molecular Mimicry between Dengue Virus and Coagulation Factors Induces Antibodies To Inhibit Thrombin Activity and Enhance Fibrinolysis Chuang, Yung-Chun; Lin, Yee-Shin; Liu, Hsiao-Sheng Journal of Virology, Vol. 88, Issue 23 https://doi.org/10.1128/JVI.02166-14	journal	December 2014
Hantavirus Causing Hemorrhagic Fever with Renal Syndrome Enters from the Apical Surface and Requires Decay-Accelerating Factor (DAF/CD55) Krautkrämer, Ellen; Zeier, Martin Journal of Virology, Vol. 82, Issue 9 https://doi.org/10.1128/JVI.02210-07	journal	May 2008
Viral Protein Determinants of Lassa Virus Entry and Release from Polarized Epithelial Cells Schlie, Katrin; Maisa, Anna; Freiberg, Fabian Journal of Virology, Vol. 84, Issue 7 https://doi.org/10.1128/JVI.02240-09	journal	April 2010
VEGFR2 and Src Kinase Inhibitors Suppress Andes Virus-Induced Endothelial Cell Permeability Gorbunova, Elena E.; Gavrilovskaya, Irina N.; Pepini, Timothy Journal of Virology, Vol. 85, Issue 5 https://doi.org/10.1128/JVI.02319-10	journal	March 2011
Hantaviruses Direct Endothelial Cell Permeability by Sensitizing Cells to the Vascular Permeability Factor VEGF, while Angiopoietin 1 and Sphingosine 1-Phosphate Inhibit Hantavirus-Directed Permeability Gavrilovskaya, Irina N.; Gorbunova, Elena E.; Mackow, Natalie A. Journal of Virology, Vol. 82, Issue 12 https://doi.org/10.1128/JVI.02397-07	journal	June 2008
Pathogenic Hantaviruses Direct the Adherence of Quiescent Platelets to Infected Endothelial Cells Gavrilovskaya, Irina N.; Gorbunova, Elena E.; Mackow, Erich R. Journal of Virology, Vol. 84, Issue 9 https://doi.org/10.1128/JVI.02405-09	journal	May 2010
Crimean-Congo Hemorrhagic Fever Virus Activates Endothelial Cells Connolly-Andersen, A. -M.; Moll, G.; Andersson, C. Journal of Virology, Vol. 85, Issue 15 https://doi.org/10.1128/JVI.02469-10	journal	June 2011
Tyrosine Residues in the Cytoplasmic Domains Affect Sorting and Fusion Activity of the Nipah Virus Glycoproteins in Polarized Epithelial Cells Weise, Carolin; Erbar, Stephanie; Lamp, Boris Journal of Virology, Vol. 84, Issue 15 https://doi.org/10.1128/JVI.02576-09	journal	August 2010
Nipah Virus Entry and Egress from Polarized Epithelial Cells Lamp, B.; Dietzel, E.; Kolesnikova, L. Journal of Virology, Vol. 87, Issue 6 https://doi.org/10.1128/JVI.02696-12	journal	January 2013
The Lack of Maturation of Ebola Virus-Infected Dendritic Cells Results from the Cooperative Effect of at Least Two Viral Domains Lubaki, N. M.; Ilinykh, P.; Pietzsch, C. Journal of Virology, Vol. 87, Issue 13 https://doi.org/10.1128/JVI.03316-12	journal	April 2013
Sensing of RNA Viruses: a Review of Innate Immune Receptors Involved in Recognizing RNA Virus Invasion Jensen, S.; Thomsen, A. R. Journal of Virology, Vol. 86, Issue 6 https://doi.org/10.1128/JVI.05738-11	journal	January 2012
Identification of Cell Surface Molecules Involved in Dystroglycan-Independent Lassa Virus Cell Entry Shimojima, M.; Stroher, U.; Ebihara, H. Journal of Virology, Vol. 86, Issue 4 https://doi.org/10.1128/JVI.06451-11	journal	December 2011
Hantavirus Infection Induces the Expression of RANTES and IP-10 without Causing Increased Permeability in Human Lung Microvascular Endothelial Cells Sundstrom, J. Bruce; McMullan, Laura K.; Spiropoulou, Christina F. Journal of Virology, Vol. 75, Issue 13 https://doi.org/10.1128/JVI.75.13.6070-6085.2001	journal	July 2001
Infection and Activation of Monocytes by Marburg and Ebola Viruses Stroher, U.; West, E.; Bugany, H. Journal of Virology, Vol. 75, Issue 22 https://doi.org/10.1128/JVI.75.22.11025-11033.2001	journal	November 2001
Membrane Fusion Tropism and Heterotypic Functional Activities of theNipah VirusandHendra VirusEnvelope Glycoproteins Bossart, Katharine N.; Wang, Lin-Fa; Flora, Michael N. Journal of Virology, Vol. 76, Issue 22 https://doi.org/10.1128/JVI.76.22.11186-11198.2002	journal	November 2002
NSs Protein of Rift Valley Fever Virus Blocks Interferon Production by Inhibiting Host Gene Transcription Billecocq, A.; Spiegel, M.; Vialat, P. Journal of Virology, Vol. 78, Issue 18 https://doi.org/10.1128/JVI.78.18.9798-9806.2004	journal	August 2004
Analysis of Human Peripheral Blood Samples from Fatal and Nonfatal Cases of Ebola (Sudan) Hemorrhagic Fever: Cellular Responses, Virus Load, and Nitric Oxide Levels Sanchez, A.; Lukwiya, M.; Bausch, D. Journal of Virology, Vol. 78, Issue 19 https://doi.org/10.1128/JVI.78.19.10370-10377.2004	journal	September 2004
Characterization of the Interaction of Lassa Fever Virus with Its Cellular Receptor α-Dystroglycan Kunz, Stefan; Rojek, Jillian M.; Perez, Mar Journal of Virology, Vol. 79, Issue 10 https://doi.org/10.1128/JVI.79.10.5979-5987.2005	journal	May 2005
Role of Ebola Virus Secreted Glycoproteins and Virus-Like Particles in Activation of Human Macrophages Wahl-Jensen, Victoria; Kurz, Sabine K.; Hazelton, Paul R. Journal of Virology, Vol. 79, Issue 4 https://doi.org/10.1128/JVI.79.4.2413-2419.2005	journal	February 2005
Bidirectional Virus Secretion and Nonciliated Cell Tropism following Andes Virus Infection of Primary Airway Epithelial Cell Cultures Rowe, Regina K.; Pekosz, Andrew Journal of Virology, Vol. 80, Issue 3 https://doi.org/10.1128/JVI.80.3.1087-1097.2006	journal	February 2006
Replication of dengue and junin viruses in cultured rabbit and human endothelial cells Andrews, B. S.; Theofilopoulos, A. N.; Peters, C. J. Infection and Immunity, Vol. 20, Issue 3 https://doi.org/10.1128/iai.20.3.776-781.1978	journal	June 1978
Nipah Virus Infection Ang, Brenda S. P.; Lim, Tchoyoson C. C.; Wang, Linfa Journal of Clinical Microbiology, Vol. 56, Issue 6 https://doi.org/10.1128/jcm.01875-17	journal	June 2018
SARS-CoV-2 Causes Severe Epithelial Inflammation and Barrier Dysfunction Deinhardt-Emmer, Stefanie; Böttcher, Sarah; Häring, Clio Journal of Virology, Vol. 95, Issue 10 https://doi.org/10.1128/jvi.00110-21	journal	April 2021
Filovirus-induced endothelial leakage triggered by infected monocytes/macrophages. Feldmann, H.; Bugany, H.; Mahner, F. Journal of virology, Vol. 70, Issue 4 https://doi.org/10.1128/jvi.70.4.2208-2214.1996	journal	January 1996
Recombinant ACE2 Expression Is Required for SARS-CoV-2 To Infect Primary Human Endothelial Cells and Induce Inflammatory and Procoagulative Responses Nascimento Conde, Jonas; Schutt, William R.; Gorbunova, Elena E. mBio, Vol. 11, Issue 6 https://doi.org/10.1128/mBio.03185-20	journal	December 2020
Ebola Virus Binding to Tim-1 on T Lymphocytes Induces a Cytokine Storm Younan, Patrick; Iampietro, Mathieu; Nishida, Andrew mBio, Vol. 8, Issue 5 https://doi.org/10.1128/mbio.00845-17	journal	November 2017
Pathogenesis of the Viral Hemorrhagic Fevers Paessler, Slobodan; Walker, David H. Annual Review of Pathology: Mechanisms of Disease, Vol. 8, Issue 1 https://doi.org/10.1146/annurev-pathol-020712-164041	journal	January 2013
Increased circulating microparticles contribute to severe infection and adverse outcomes of COVID-19 in patients with diabetes Sun, Haoyu; Du, Yong; Kumar, Rinki American Journal of Physiology-Heart and Circulatory Physiology, Vol. 323, Issue 6 https://doi.org/10.1152/ajpheart.00409.2022	journal	December 2022
Cells in Dengue Virus Infection In Vivo Noisakran, Sansanee; Onlamoon, Nattawat; Songprakhon, Pucharee Advances in Virology, Vol. 2010 https://doi.org/10.1155/2010/164878	journal	January 2010
Elevated VEGF Levels in Pulmonary Edema Fluid and PBMCs from Patients with Acute Hantavirus Pulmonary Syndrome Gavrilovskaya, Irina; Gorbunova, Elena; Koster, Frederick Advances in Virology, Vol. 2012 https://doi.org/10.1155/2012/674360	journal	January 2012
Endothelial cell function alteration after Junin virus infection Gomez, Ricardo Martin; Pozner, Roberto Gabriel; Lazzari, Maria Angela Thrombosis and Haemostasis, Vol. 90, Issue 08 https://doi.org/10.1160/TH02-09-0043	journal	January 2003
Antibodies against thrombin in dengue patients contain both anti-thrombotic and pro-fibrinolytic activities Chuang, Yung-Chun; Lin, Yee-Shin; Liu, Hsiao-Sheng Thrombosis and Haemostasis, Vol. 110, Issue 08 https://doi.org/10.1160/TH13-02-0149	journal	January 2013
Platelets and SARS-CoV-2 During COVID-19: Immunity, Thrombosis, and Beyond Sciaudone, Anthony; Corkrey, Heather; Humphries, Fiachra Circulation Research, Vol. 132, Issue 10 https://doi.org/10.1161/CIRCRESAHA.122.321930	journal	May 2023
Injury to the Endothelial Glycocalyx in Critically Ill Patients with COVID-19 Stahl, Klaus; Gronski, Phillip Alexander; Kiyan, Yulia American Journal of Respiratory and Critical Care Medicine, Vol. 202, Issue 8 https://doi.org/10.1164/rccm.202007-2676LE	journal	October 2020
Replication of Marburg virus in human endothelial cells. A possible mechanism for the development of viral hemorrhagic disease. Schnittler, H. J.; Mahner, F.; Drenckhahn, D. Journal of Clinical Investigation, Vol. 91, Issue 4 https://doi.org/10.1172/JCI116329	journal	April 1993
In vitro modeling of the microvascular occlusion and thrombosis that occur in hematologic diseases using microfluidic technology Tsai, Michelle; Kita, Ashley; Leach, Joseph Journal of Clinical Investigation, Vol. 122, Issue 1 https://doi.org/10.1172/JCI58753	journal	January 2012
Blood kinetics of Ebola virus in survivors and nonsurvivors Lanini, Simone; Portella, Gina; Vairo, Francesco Journal of Clinical Investigation, Vol. 125, Issue 12 https://doi.org/10.1172/JCI83111	journal	October 2015
Immune parameters and outcomes during Ebola virus disease Reynard, Stéphanie; Journeaux, Alexandra; Gloaguen, Emilie JCI Insight, Vol. 4, Issue 1 https://doi.org/10.1172/jci.insight.125106	journal	January 2019
Neutrophil accumulation and NET release contribute to thrombosis in HIT Gollomp, Kandace; Kim, Minna; Johnston, Ian JCI Insight, Vol. 3, Issue 18 https://doi.org/10.1172/jci.insight.99445	journal	September 2018
Elevated Vascular Endothelial Growth Factor Levels Induce Hyperpermeability of Endothelial Cells in Hantavirus Infection Li, Y.; Wang, W.; Wang, J-P Journal of International Medical Research, Vol. 40, Issue 5 https://doi.org/10.1177/030006051204000519	journal	October 2012
Mean Platelet Volume in the Diagnosis and Prognosis of Crimean–Congo Hemorrhagic Fever Ekiz, Fuat; Gürbüz, Yunus; Başar, Ömer Clinical and Applied Thrombosis/Hemostasis, Vol. 19, Issue 4 https://doi.org/10.1177/1076029612440035	journal	March 2012
Diabetes affects endothelial cell function and alters fibrin clot formation in a microvascular flow model: A pilot study Jenny, Lorenz; Melmer, Andreas; Laimer, Markus Diabetes and Vascular Disease Research, Vol. 17, Issue 1 https://doi.org/10.1177/1479164120903044	journal	January 2020
Coagulopathy in liver disease: a balancing act Kujovich, Jody L. Hematology, Vol. 2015, Issue 1 https://doi.org/10.1182/asheducation-2015.1.243	journal	December 2015
ICAM-1–targeted thrombomodulin mitigates tissue factor–driven inflammatory thrombosis in a human endothelialized microfluidic model Greineder, Colin F.; Johnston, Ian H.; Villa, Carlos H. Blood Advances, Vol. 1, Issue 18 https://doi.org/10.1182/bloodadvances.2017007229	journal	August 2017
Lassa and Marburg viruses elicit distinct host transcriptional responses early after infection Caballero, Ignacio S.; Yen, Judy Y.; Hensley, Lisa E. BMC Genomics, Vol. 15, Issue 1 https://doi.org/10.1186/1471-2164-15-960	journal	January 2014
The severity of Puumala hantavirus induced nephropathia epidemica can be better evaluated using plasma interleukin-6 than C-reactive protein determinations Outinen, Tuula K.; Mäkelä, Satu M.; Ala-Houhala, Ilpo O. BMC Infectious Diseases, Vol. 10, Issue 1 https://doi.org/10.1186/1471-2334-10-132	journal	May 2010
Nipah virus infection and glycoprotein targeting in endothelial cells Erbar, Stephanie; Maisner, Andrea Virology Journal, Vol. 7, Issue 1 https://doi.org/10.1186/1743-422X-7-305	journal	November 2010
Infection of human monocyte-derived dendritic cells by ANDES Hantavirus enhances pro-inflammatory state, the secretion of active MMP-9 and indirectly enhances endothelial permeability Marsac, Delphine; García, Stephanie; Fournet, Alexandra Virology Journal, Vol. 8, Issue 1 https://doi.org/10.1186/1743-422X-8-223	journal	January 2011
Diverse functions of miR-125 family in different cell contexts Sun, Yu-Meng; Lin, Kang-Yu; Chen, Yue-Qin Journal of Hematology & Oncology, Vol. 6, Issue 1 https://doi.org/10.1186/1756-8722-6-6	journal	January 2013
The monocyte-macrophage-mast cell axis in dengue pathogenesis Wan, Shu-Wen; Wu-Hsieh, Betty A.; Lin, Yee-Shin Journal of Biomedical Science, Vol. 25, Issue 1 https://doi.org/10.1186/s12929-018-0482-9	journal	November 2018
Heparan sulfate is an important mediator of Ebola virus infection in polarized epithelial cells Tamhankar, Manasi; Gerhardt, Dawn M.; Bennett, Richard S. Virology Journal, Vol. 15, Issue 1 https://doi.org/10.1186/s12985-018-1045-0	journal	August 2018
Ebola virus disease and critical illness Leligdowicz, Aleksandra; Fischer, William A.; Uyeki, Timothy M. Critical Care, Vol. 20, Issue 1 https://doi.org/10.1186/s13054-016-1325-2	journal	July 2016
Molecular mimicry between virus and host and its implications for dengue disease pathogenesis Lin, Yee-Shin; Yeh, Trai-Ming; Lin, Chiou-Feng Experimental Biology and Medicine, Vol. 236, Issue 5 https://doi.org/10.1258/ebm.2011.010339	journal	May 2011
Lymphopenia: A useful predictor of COVID-19 disease severity and mortality Toori, Kaleem Ullah; Qureshi, Muhammad Arsalan; Chaudhry, Asma Pakistan Journal of Medical Sciences, Vol. 37, Issue 7 https://doi.org/10.12669/pjms.37.7.4085	journal	September 2021
Use of Viremia to Evaluate the Baseline Case Fatality Ratio of Ebola Virus Disease and Inform Treatment Studies: A Retrospective Cohort Study Faye, Oumar; Andronico, Alessio; Faye, Ousmane PLOS Medicine, Vol. 12, Issue 12 https://doi.org/10.1371/journal.pmed.1001908	journal	December 2015
Transcriptome Analysis of Human Peripheral Blood Mononuclear Cells Exposed to Lassa Virus and to the Attenuated Mopeia/Lassa Reassortant 29 (ML29), a Vaccine Candidate Zapata, Juan Carlos; Carrion, Ricardo; Patterson, Jean L. PLoS Neglected Tropical Diseases, Vol. 7, Issue 9 https://doi.org/10.1371/journal.pntd.0002406	journal	September 2013
The Role of Platelets in the Pathogenesis of Viral Hemorrhagic Fevers Zapata, Juan C.; Cox, Dermot; Salvato, Maria S. PLoS Neglected Tropical Diseases, Vol. 8, Issue 6 https://doi.org/10.1371/journal.pntd.0002858	journal	June 2014
Serum Metabolomics Reveals Serotonin as a Predictor of Severe Dengue in the Early Phase of Dengue Fever Cui, Liang; Lee, Yie Hou; Thein, Tun Linn PLOS Neglected Tropical Diseases, Vol. 10, Issue 4 https://doi.org/10.1371/journal.pntd.0004607	journal	April 2016
Long-lived CD8+ T cell responses following Crimean-Congo haemorrhagic fever virus infection Goedhals, Dominique; Paweska, Janusz T.; Burt, Felicity J. PLOS Neglected Tropical Diseases, Vol. 11, Issue 12 https://doi.org/10.1371/journal.pntd.0006149	journal	December 2017
Host gene expression profiles in ferrets infected with genetically distinct henipavirus strains Leon, Alberto J.; Borisevich, Viktoriya; Boroumand, Nahal PLOS Neglected Tropical Diseases, Vol. 12, Issue 3 https://doi.org/10.1371/journal.pntd.0006343	journal	March 2018
Rift valley fever viral load correlates with the human inflammatory response and coagulation pathway abnormalities in humans with hemorrhagic manifestations de St. Maurice, Annabelle; Harmon, Jessica; Nyakarahuka, Luke PLOS Neglected Tropical Diseases, Vol. 12, Issue 5 https://doi.org/10.1371/journal.pntd.0006460	journal	May 2018
Dengue viruses infect human megakaryocytes, with probable clinical consequences Vogt, Megan B.; Lahon, Anismrita; Arya, Ravi P. PLOS Neglected Tropical Diseases, Vol. 13, Issue 11 https://doi.org/10.1371/journal.pntd.0007837	journal	November 2019
Hazara virus and Crimean-Congo Hemorrhagic Fever Virus show a different pattern of entry in fully-polarized Caco-2 cell line Monteil, Vanessa; Salata, Cristiano; Appelberg, Sofia PLOS Neglected Tropical Diseases, Vol. 14, Issue 11 https://doi.org/10.1371/journal.pntd.0008863	journal	November 2020
Evidence of Disseminated Intravascular Coagulation in a Hemorrhagic Fever with Renal Syndrome—Scoring Models and Severe Illness Sundberg, Erik; Hultdin, Johan; Nilsson, Sofie PLoS ONE, Vol. 6, Issue 6 https://doi.org/10.1371/journal.pone.0021134	journal	June 2011
Nonspreading Rift Valley Fever Virus Infection of Human Dendritic Cells Results in Downregulation of CD83 and Full Maturation of Bystander Cells Oreshkova, Nadia; Wichgers Schreur, Paul J.; Spel, Lotte PLOS ONE, Vol. 10, Issue 11 https://doi.org/10.1371/journal.pone.0142670	journal	November 2015
MASP-1 of the complement system enhances clot formation in a microvascular whole blood flow model Jenny, Lorenz; Dobó, József; Gál, Péter PLOS ONE, Vol. 13, Issue 1 https://doi.org/10.1371/journal.pone.0191292	journal	January 2018
SARS-CoV-2 viremia and COVID-19 mortality: A prospective observational study Giacomelli, Andrea; Righini, Elena; Micheli, Valeria PLOS ONE, Vol. 18, Issue 4 https://doi.org/10.1371/journal.pone.0281052	journal	April 2023
Secreted NS1 of Dengue Virus Attaches to the Surface of Cells via Interactions with Heparan Sulfate and Chondroitin Sulfate E Avirutnan, Panisadee; Zhang, Lijuan; Punyadee, Nuntaya PLoS Pathogens, Vol. 3, Issue 11 https://doi.org/10.1371/journal.ppat.0030183	journal	November 2007
Endothelial Galectin-1 Binds to Specific Glycans on Nipah Virus Fusion Protein and Inhibits Maturation, Mobility, and Function to Block Syncytia Formation Garner, Omai B.; Aguilar, Hector C.; Fulcher, Jennifer A. PLoS Pathogens, Vol. 6, Issue 7 https://doi.org/10.1371/journal.ppat.1000993	journal	July 2010
Dengue Virus NS1 Disrupts the Endothelial Glycocalyx, Leading to Hyperpermeability Puerta-Guardo, Henry; Glasner, Dustin R.; Harris, Eva PLOS Pathogens, Vol. 12, Issue 7 https://doi.org/10.1371/journal.ppat.1005738	journal	July 2016
Dengue virus NS1 cytokine-independent vascular leak is dependent on endothelial glycocalyx components Glasner, Dustin R.; Ratnasiri, Kalani; Puerta-Guardo, Henry PLOS Pathogens, Vol. 13, Issue 11 https://doi.org/10.1371/journal.ppat.1006673	journal	November 2017
Lassa virus activates myeloid dendritic cells but suppresses their ability to stimulate T cells Schaeffer, Justine; Carnec, Xavier; Reynard, Stéphanie PLOS Pathogens, Vol. 14, Issue 11 https://doi.org/10.1371/journal.ppat.1007430	journal	November 2018
Ebola virus-mediated T-lymphocyte depletion is the result of an abortive infection Younan, Patrick; Santos, Rodrigo I.; Ramanathan, Palaniappan PLOS Pathogens, Vol. 15, Issue 10 https://doi.org/10.1371/journal.ppat.1008068	journal	October 2019
DENV NS1 and MMP-9 cooperate to induce vascular leakage by altering endothelial cell adhesion and tight junction Pan, Pan; Li, Geng; Shen, Miaomiao PLOS Pathogens, Vol. 17, Issue 7 https://doi.org/10.1371/journal.ppat.1008603	journal	July 2021
High-throughput, single-copy sequencing reveals SARS-CoV-2 spike variants coincident with mounting humoral immunity during acute COVID-19 Ko, Sung Hee; Bayat Mokhtari, Elham; Mudvari, Prakriti PLOS Pathogens, Vol. 17, Issue 4 https://doi.org/10.1371/journal.ppat.1009431	journal	April 2021
Rapid endotheliitis and vascular damage characterize SARS‐CoV‐2 infection in a human lung‐on‐chip model Thacker, Vivek V.; Sharma, Kunal; Dhar, Neeraj EMBO reports, Vol. 22, Issue 6 https://doi.org/10.15252/embr.202152744	journal	May 2021
COVID-19–Associated Kidney Injury: A Case Series of Kidney Biopsy Findings Sharma, Purva; Uppal, Nupur N.; Wanchoo, Rimda Journal of the American Society of Nephrology, Vol. 31, Issue 9 https://doi.org/10.1681/ASN.2020050699	journal	July 2020
Treatment of dengue fever Rajapakse, Senaka; Rodrigo, Chaturaka Infection and Drug Resistance https://doi.org/10.2147/IDR.S22613	journal	July 2012
Elevated TNF-α Induces Thrombophagocytosis by Mononuclear Cells in ex vivo Whole-Blood Co-Culture with Dengue Virus Satria, Rahmat Dani; Jhan, Ming-Kai; Chen, Chia-Ling Journal of Inflammation Research, Vol. Volume 15 https://doi.org/10.2147/JIR.S356742	journal	March 2022
Hantaviruses: Molecular Biology, Evolution and Pathogenesis Khaiboullina, Svetlana; Morzunov, S.; St. Jeor, Stephen Current Molecular Medicine, Vol. 5, Issue 8 https://doi.org/10.2174/156652405774962317	journal	December 2005
Elucidating the Role of T cells in Protection Against and Pathogenesis of Dengue Virus Infections Mathew, Anuja; Townsley, Elizabeth; Ennis, Francis A. Future Microbiology, Vol. 9, Issue 3 https://doi.org/10.2217/fmb.13.171	journal	March 2014
A severe case of Puumala hantavirus infection successfully treated with bradykinin receptor antagonist icatibant Antonen, Jaakko; Leppänen, Ilona; Tenhunen, Jyrki Scandinavian Journal of Infectious Diseases, Vol. 45, Issue 6 https://doi.org/10.3109/00365548.2012.755268	journal	January 2013
Virus Detection and Monitoring of Viral Load in Crimean-Congo Hemorrhagic Fever Virus Patients Wölfel, Roman; Paweska, Janusz T.; Petersen, Nadine Emerging Infectious Diseases, Vol. 13, Issue 7 https://doi.org/10.3201/eid1307.070068	journal	July 2007
Viral Load as Predictor of Crimean-Congo Hemorrhagic Fever Outcome Duh, Darja; Saksida, Ana; Petrovec, Miroslav Emerging Infectious Diseases, Vol. 13, Issue 11 https://doi.org/10.3201/eid1311.070222	journal	November 2007
Hantavirus Pulmonary Syndrome, United States, 1993–2009 MacNeil, Adam; Ksiazek, Thomas G.; Rollin, Pierre E. Emerging Infectious Diseases, Vol. 17, Issue 7 https://doi.org/10.3201/eid1707.101306	journal	July 2011
Twenty-Year Summary of Surveillance for Human Hantavirus Infections, United States Knust, Barbara; Rollin, Pierre E. Emerging Infectious Diseases, Vol. 19, Issue 12 https://doi.org/10.3201/eid1912.131217	journal	December 2013
Pulmonary Embolism and Increased Levels of d-Dimer in Patients with Coronavirus Disease Griffin, Daniel O.; Jensen, Alexandra; Khan, Mushmoom Emerging Infectious Diseases, Vol. 26, Issue 8 https://doi.org/10.3201/eid2608.201477	journal	August 2020
Endotheliopathy and Platelet Dysfunction as Hallmarks of Fatal Lassa Fever Horton, Lucy E.; Cross, Robert W.; Hartnett, Jessica N. Emerging Infectious Diseases, Vol. 26, Issue 11 https://doi.org/10.3201/eid2611.191694	journal	November 2020
Upregulation of P2Y2R, Active uPA, and PAI-1 Are Essential Components of Hantavirus Cardiopulmonary Syndrome Bondu, Virginie; Bitting, Casey; Poland, Valerie L. Frontiers in Cellular and Infection Microbiology, Vol. 8 https://doi.org/10.3389/fcimb.2018.00169	journal	May 2018
Orthohantavirus Pathogenesis and Cell Tropism Noack, Danny; Goeijenbier, Marco; Reusken, Chantal B. E. M. Frontiers in Cellular and Infection Microbiology, Vol. 10 https://doi.org/10.3389/fcimb.2020.00399	journal	August 2020
Multiplex Analysis of Serum Cytokines in Humans with Hantavirus Pulmonary Syndrome Morzunov, Sergey P.; Khaiboullina, Svetlana F.; St. Jeor, Stephen Frontiers in Immunology, Vol. 6 https://doi.org/10.3389/fimmu.2015.00432	journal	August 2015
SARS-CoV-2 Poorly Replicates in Cells of the Human Blood-Brain Barrier Without Associated Deleterious Effects Constant, Orianne; Barthelemy, Jonathan; Bolloré, Karine Frontiers in Immunology, Vol. 12 https://doi.org/10.3389/fimmu.2021.697329	journal	July 2021
Infection of Endothelial Cells by Dengue Virus Induces ROS Production by Different Sources Affecting Virus Replication, Cellular Activation, Death and Vascular Permeability Meuren, Lana Monteiro; Prestes, Elisa Beatriz; Papa, Michelle Premazzi Frontiers in Immunology, Vol. 13 https://doi.org/10.3389/fimmu.2022.810376	journal	February 2022
Depletion and Dysfunction of Dendritic Cells: Understanding SARS-CoV-2 Infection Chang, Teding; Yang, Jingzhi; Deng, Hai Frontiers in Immunology, Vol. 13 https://doi.org/10.3389/fimmu.2022.843342	journal	February 2022
Vascular inflammation on a chip: A scalable platform for trans-endothelial electrical resistance and immune cell migration Ehlers, Haley; Nicolas, Arnaud; Schavemaker, Frederik Frontiers in Immunology, Vol. 14 https://doi.org/10.3389/fimmu.2023.1118624	journal	January 2023
High levels of exfoliated fragments following glycocalyx destruction in hemorrhagic fever with the renal syndrome are associated with mortality risk Du, Hong; Hu, Haifeng; Li, Jing Frontiers in Medicine, Vol. 10 https://doi.org/10.3389/fmed.2023.1096353	journal	April 2023
Nipah Virus Efficiently Replicates in Human Smooth Muscle Cells without Cytopathic Effect DeBuysscher, Blair L.; Scott, Dana P.; Rosenke, Rebecca Cells, Vol. 10, Issue 6 https://doi.org/10.3390/cells10061319	journal	May 2021
Thromboinflammation Model-on-A-Chip by Whole Blood Microfluidics on Fixed Human Endothelium Dupuy, Alexander; Hagimola, Lejla; Mgaieth, Neil S. A. Diagnostics, Vol. 11, Issue 2 https://doi.org/10.3390/diagnostics11020203	journal	January 2021
A Microfluidic 3D Endothelium-on-a-Chip Model to Study Transendothelial Migration of T Cells in Health and Disease de Haan, Luuk; Suijker, Johnny; van Roey, Ruthger International Journal of Molecular Sciences, Vol. 22, Issue 15 https://doi.org/10.3390/ijms22158234	journal	July 2021
Automated Analysis of Platelet Aggregation on Cultured Endothelium in a Microfluidic Chip Perfused with Human Whole Blood Albers, Hugo; Passier, Robert; van den Berg, Albert Micromachines, Vol. 10, Issue 11 https://doi.org/10.3390/mi10110781	journal	November 2019
Lipopolysaccharide-Induced Vascular Inflammation Model on Microfluidic Chip Nam, Ungsig; Kim, Seunggyu; Park, Joonha Micromachines, Vol. 11, Issue 8 https://doi.org/10.3390/mi11080747	journal	July 2020
Modular 3D In Vitro Artery-Mimicking Multichannel System for Recapitulating Vascular Stenosis and Inflammation Cho, Minkyung; Park, Je-Kyun Micromachines, Vol. 12, Issue 12 https://doi.org/10.3390/mi12121528	journal	December 2021
The Immunobiology of Nipah Virus Liew, Yvonne Jing Mei; Ibrahim, Puteri Ainaa S.; Ong, Hui Ming Microorganisms, Vol. 10, Issue 6 https://doi.org/10.3390/microorganisms10061162	journal	June 2022
T-Cells and Interferon Gamma Are Necessary for Survival Following Crimean-Congo Hemorrhagic Fever Virus Infection in Mice Hawman, David W.; Meade-White, Kimberly; Leventhal, Shanna Microorganisms, Vol. 9, Issue 2 https://doi.org/10.3390/microorganisms9020279	journal	January 2021
Endothelium Activation during Severe Yellow Fever Triggers an Intense Cytokine-Mediated Inflammatory Response in the Liver Parenchyma Olímpio, Fábio Alves; Falcão, Luiz Fábio Magno; Carvalho, Marcos Luiz Gaia Pathogens, Vol. 11, Issue 1 https://doi.org/10.3390/pathogens11010101	journal	January 2022
Dendritic Cells (DCs) as “Fire Accelerants” of Hantaviral Pathogenesis Schönrich, Günther; Raftery, Martin J. Viruses, Vol. 11, Issue 9 https://doi.org/10.3390/v11090849	journal	September 2019
Ebola Virus Uptake into Polarized Cells from the Apical Surface Hu, Meng; Wang, Fei; Li, Wei Viruses, Vol. 11, Issue 12 https://doi.org/10.3390/v11121117	journal	December 2019
Insight into the Tropism of Dengue Virus in Humans Begum, Feroza; Das, Sandeepan; Mukherjee, Debica Viruses, Vol. 11, Issue 12 https://doi.org/10.3390/v11121136	journal	December 2019
Insights into the Pathogenesis of Viral Haemorrhagic Fever Based on Virus Tropism and Tissue Lesions of Natural Rift Valley Fever Odendaal, Lieza; Davis, A. Sally; Venter, Estelle H. Viruses, Vol. 13, Issue 4 https://doi.org/10.3390/v13040709	journal	April 2021
Infection of Human Endothelial Cells with Lassa Virus Induces Early but Transient Activation and Low Type I IFN Response Compared to the Closely-Related Nonpathogenic Mopeia Virus Merabet, Othmann; Pietrosemoli, Natalia; Perthame, Emeline Viruses, Vol. 14, Issue 3 https://doi.org/10.3390/v14030652	journal	March 2022
Puumala Hantavirus Infections Show Extensive Variation in Clinical Outcome Vaheri, Antti; Smura, Teemu; Vauhkonen, Hanna Viruses, Vol. 15, Issue 3 https://doi.org/10.3390/v15030805	journal	March 2023
T Cells and Pathogenesis of Hantavirus Cardiopulmonary Syndrome and Hemorrhagic Fever with Renal Syndrome Terajima, Masanori; Ennis, Francis A. Viruses, Vol. 3, Issue 7 https://doi.org/10.3390/v3071059	journal	July 2011
Pathogenesis of Lassa Fever Yun, Nadezhda E.; Walker, David H. Viruses, Vol. 4, Issue 10 https://doi.org/10.3390/v4102031	journal	October 2012
Junín Virus Pathogenesis and Virus Replication Grant, Ashley; Seregin, Alexey; Huang, Cheng Viruses, Vol. 4, Issue 10 https://doi.org/10.3390/v4102317	journal	October 2012
T-Cell Response to Viral Hemorrhagic Fevers Perdomo-Celis, Federico; Salvato, Maria S.; Medina-Moreno, Sandra Vaccines, Vol. 7, Issue 1 https://doi.org/10.3390/vaccines7010011	journal	January 2019
Biomimetic Alveolus-on-a-Chip for SARS-CoV-2 Infection Recapitulation Cao, Ting; Shao, Changmin; Yu, Xiaoyu Research, Vol. 2022 https://doi.org/10.34133/2022/9819154	journal	January 2022
Maporal Virus as a Surrogate for Pathogenic New World Hantaviruses and its Inhibition by Favipiravir Buys, Kristin K.; Jung, Kie-Hoon; Smee, Donald F. Antiviral Chemistry and Chemotherapy, Vol. 21, Issue 5 https://doi.org/10.3851/IMP1729	journal	January 2011
Dengue Virus Nonstructural Protein 1–Induced Antibodies Cross-React with Human Plasminogen and Enhance Its Activation Chuang, Yung-Chun; Lin, Jessica; Lin, Yee-Shin The Journal of Immunology, Vol. 196, Issue 3 https://doi.org/10.4049/jimmunol.1500057	journal	December 2015
Dengue Virus Infection of Human Endothelial Cells Leads to Chemokine Production, Complement Activation, and Apoptosis Avirutnan, Panisadee; Malasit, Prida; Seliger, Barbara The Journal of Immunology, Vol. 161, Issue 11 https://doi.org/10.4049/jimmunol.161.11.6338	journal	December 1998
Cutting Edge: Impairment of Dendritic Cells and Adaptive Immunity by Ebola and Lassa Viruses Mahanty, Siddhartha; Hutchinson, Karen; Agarwal, Sudhanshu The Journal of Immunology, Vol. 170, Issue 6 https://doi.org/10.4049/jimmunol.170.6.2797	journal	March 2003
Of Mice and Not Men: Differences between Mouse and Human Immunology Mestas, Javier; Hughes, Christopher C. W. The Journal of Immunology, Vol. 172, Issue 5 https://doi.org/10.4049/jimmunol.172.5.2731	journal	February 2004
Lassa Virus Infection of Human Dendritic Cells and Macrophages Is Productive but Fails to Activate Cells Baize, Sylvain; Kaplon, Jérôme; Faure, Caroline The Journal of Immunology, Vol. 172, Issue 5 https://doi.org/10.4049/jimmunol.172.5.2861	journal	February 2004
Endothelial Cell Permeability and Adherens Junction Disruption Induced by Junín Virus Infection Lander, Heather M.; Grant, Ashley M.; Albrecht, Thomas The American Society of Tropical Medicine and Hygiene, Vol. 90, Issue 6 https://doi.org/10.4269/ajtmh.13-0382	journal	June 2014
Pathology of 12 fatal cases of Argentine hemorrhagic fever * Elsner, Boris; Maiztegui, Julio; Vilches, Antonio The American Journal of Tropical Medicine and Hygiene, Vol. 22, Issue 2 https://doi.org/10.4269/ajtmh.1973.22.229	journal	March 1973
Demonstration of Dengue Antibody Complexes on the Surface of Platelets from Patients with Dengue Hemorrhagic Fever Boonpucknavig, Somnate; Vuttiviroj, Oranut; Bunnag, Chaujitr The American Journal of Tropical Medicine and Hygiene, Vol. 28, Issue 5 https://doi.org/10.4269/ajtmh.1979.28.881	journal	September 1979
Platelet adhesion to dengue-2 virus-infected endothelial cells. Krishnamurti, Chitra; Cutting, Mary A.; Peat, Raquel A. The American Journal of Tropical Medicine and Hygiene, Vol. 66, Issue 4 https://doi.org/10.4269/ajtmh.2002.66.435	journal	April 2002
Tropism of Dengue Virus in Mice and Humans Defined by Viral Nonstructural Protein 3-Specific Immunostaining Flores, Diana; Coloma, Josefina; Beatty, P. Robert The American Journal of Tropical Medicine and Hygiene, Vol. 80, Issue 3 https://doi.org/10.4269/ajtmh.2009.80.416	journal	March 2009
Type I interferon underlies severe disease associated with Junín virus infection in mice Hickerson, Brady T.; Sefing, Eric J.; Bailey, Kevin W. eLife, Vol. 9 https://doi.org/10.7554/eLife.55352	journal	May 2020
Multi-omics insights into host-viral response and pathogenesis in Crimean-Congo hemorrhagic fever viruses for novel therapeutic target Neogi, Ujjwal; Elaldi, Nazif; Appelberg, Sofia eLife, Vol. 11 https://doi.org/10.7554/eLife.76071	journal	April 2022