Engineered human vascular models to study endothelial dysfunction in infectious disease

Technical Report · Fri Dec 22 04:00:00 EST 2023

DOI:https://doi.org/10.2172/2280887· OSTI ID:2280887

Moya, Monica L. ^[1]

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1. Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

Vascular involvement plays a pivotal role in the pathogenesis of numerous emerging viral threats, with climate changes amplifying the likelihood of these diseases evolving into pandemics. Establishing an infectable and physiologically relevant human in vitro model holds immense importance in comprehending the pathogenesis of these threats and devising effective countermeasures. Although in vivo models provide valuable insight into disease, their application is restricted by interspecies variations, particularly concerning pathogens exclusive to humans. Moreover, animal models often fail to replicate comorbidities prevalent in patient populations, thus limiting our understanding of disease behavior in humans. In this study, we have devised a testing platform aimed at exploring pathogen interactions with innate immunity within the vasculature, encompassing both healthy and dysfunctional endothelial conditions.

• Research Organization: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
• Sponsoring Organization: USDOE National Nuclear Security Administration (NNSA)
• DOE Contract Number: AC52-07NA27344
• OSTI ID: 2280887
• Report Number(s): LLNL--TR-858756; 1089306
• Country of Publication: United States
• Language: English

Related Subjects

42 ENGINEERING
59 BASIC BIOLOGICAL SCIENCES