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Trends in HPV- and non-HPV-associated vulvar cancer incidence, United States, 2001–2017

Journal Article · · Preventive Medicine
 [1];  [1];  [2];  [3]
  1. Centers for Disease Control and Prevention, Atlanta, GA (United States); Oak Ridge Institute for Science and Education (ORISE), Oak Ridge, TN (United States)
  2. Adventist Health White Memorial Medical Center, Los Angeles, CA (United States)
  3. Centers for Disease Control and Prevention, Atlanta, GA (United States)
+ Show Author Affiliations
Vulvar cancer incidence has been rising in recent years, possibly due to increasing exposure to human papillomavirus (HPV). We assessed incidence rates of HPV-associated and non-HPV-associated vulvar cancers diagnosed from 2001 to 2017 in the United States (US). Using population-based cancer registry data covering 99% of the US population, incidence rates were calculated and stratified by age, race/ethnicity, stage, geographic region, and histology. The average annual percent change in incidence per year were calculated using joinpoint regression. From 2001 to 2017, the incidence of HPV-associated vulvar cancers increased by 1.2% per year, most notably among women who were aged 50–59 years (2.6%), 60–69 years (2.4%), and ≥ 70 years (0.9%); of White (1.5%) and Black (1.1%) race; diagnosed at an early (1.3%) and late (1.8%) stage; and living in the Midwest (1.9%), Northeast (1.4%), and South (1.2%). Incidence increased each year for HPV-associated histologic subtypes including keratinizing (4.7%), non-keratinizing (6.0%), and basaloid (3.1%) squamous cell carcinomas (SCCs), while decreases were found in warty (2.7%) and microinvasive (5.5%) SCCs. HPV-associated vulvar cancer incidence increased overall and among women aged over 50 years while remaining stable among women younger than 50 years. Furthermore, the overall incidence for non-HPV-associated cancers was stable. Continued surveillance of HPV-associated cancers will allow us to monitor future trends as HPV vaccination coverage increases in the US.
Research Organization:
Oak Ridge Institute for Science and Education (ORISE), Oak Ridge, TN (United States)
Sponsoring Organization:
USDOE; USDOE Office of Science (SC)
Grant/Contract Number:
SC0014664
OSTI ID:
2425830
Alternate ID(s):
OSTI ID: 1962920
Journal Information:
Preventive Medicine, Journal Name: Preventive Medicine Journal Issue: C Vol. 164; ISSN 0091-7435
Publisher:
ElsevierCopyright Statement
Country of Publication:
United States
Language:
English

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Related Subjects

60 APPLIED LIFE SCIENCES
General & Internal Medicine
HPV
HPV-associated cancer
Public
Environmental & Occupational Health
incidence
trends
vulvar cancer