Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

High-Grade Vulvar, Vaginal, and Anal Precancers Among U.S. Adolescents and Young Adults After Human Papillomavirus Vaccine Introduction

Journal Article · · American Journal of Preventive Medicine
 [1];  [2];  [2];  [2]
  1. Centers for Disease Control and Prevention (CDC), Atlanta, GA (United States); Oak Ridge Institute for Science and Education (ORISE), Oak Ridge, TN (United States)
  2. Centers for Disease Control and Prevention (CDC), Atlanta, GA (United States)
+ Show Author Affiliations
Since human papillomavirus vaccine introduction, incidence rates of cervical precancers have decreased; however, the vaccine's impact on noncervical anogenital precancers has not been shown. These precancers are identified opportunistically and are not collected routinely by most cancer registries. This study examined the incidence rates of high-grade (intraepithelial lesions grade 3) vulvar, vaginal, and anal precancers among persons aged 15–39 years using 2000–2017 data from select cancer registries covering 27.8% of the U.S. population that required reporting of these precancers. Trends in incidence rates were evaluated with Joinpoint regression. Analyses were conducted in 2020. High-grade vulvar precancer rates declined by 21.0% per year after human papillomavirus vaccine introduction among females aged 15–19 years. In addition, high-grade vaginal precancer rates declined by 19.1% per year among females aged 15–29 years after human papillomavirus vaccine introduction. Compared with that in the prevaccine period when high-grade anal precancer rates were increasing, anal precancer rates after human papillomavirus vaccine introduction were stable among females aged 15–29 years and among males aged 30–39 years. Among males aged 15–29 years, the rates increased over the entire period but less so after human papillomavirus vaccine introduction. In conclusion, opportunistically-detected high-grade vulvar and vaginal precancers among females aged 15–29 years decreased and anal precancers stabilized in years after the introduction of the human papillomavirus vaccine, which is suggestive of the impact of the vaccine on noncervical human papillomavirus cancers.
Research Organization:
Oak Ridge Institute for Science and Education (ORISE), Oak Ridge, TN (United States)
Sponsoring Organization:
USDOE; USDOE Office of Science (SC)
Grant/Contract Number:
SC0014664
OSTI ID:
1981537
Alternate ID(s):
OSTI ID: 1868686
Journal Information:
American Journal of Preventive Medicine, Journal Name: American Journal of Preventive Medicine Journal Issue: 1 Vol. 62; ISSN 0749-3797
Publisher:
ElsevierCopyright Statement
Country of Publication:
United States
Language:
English

References (18)

Effect of Human Papillomavirus Vaccine to Interrupt Recurrence of Vulvar and Anal Neoplasia (VIVA): A Trial Protocol journal April 2019
Population-Based Incidence Rates of Cervical Intraepithelial Neoplasia in the Human Papillomavirus Vaccine Era journal June 2017
Permutation tests for joinpoint regression with applications to cancer rates journal February 2000
Incidence of in situ and invasive vulvar cancer in the US, 1998-2003 journal November 2008
Trends in the occurrence of high-grade anal intraepithelial neoplasia in San Francisco: 2000-2009: Trends in High-Grade AIN journal July 2013
Cervical adenocarcinoma in situ : Human papillomavirus types and incidence trends in five states, 2008–2015 journal April 2019
Improved confidence interval for average annual percent change in trend analysis: H.-J. KIM ET AL. journal June 2017
Evolution of cervical cancer screening and prevention in United States and Canada: Implications for public health practitioners and clinicians journal November 2013
Carcinogenic human papillomavirus infection journal December 2016
Trends in High-grade Cervical Lesions and Cervical Cancer Screening in 5 States, 2008–2015 journal August 2018
Prevalence of Genital Human Papillomavirus in Males, United States, 2013–2014 journal February 2017
Prevalence of Human Papillomavirus Among Females After Vaccine Introduction—National Health and Nutrition Examination Survey, United States, 2003–2014 journal June 2017
US Assessment of HPV Types in Cancers: Implications for Current and 9-Valent HPV Vaccines journal April 2015
Trends in the Incidence of Invasive and In Situ Vulvar Carcinoma journal January 2006
Assessing Impact of HPV Vaccination on Cervical Cancer Incidence among Women Aged 15–29 Years in the United States, 1999–2017: An Ecologic Study journal October 2020
National, Regional, State, and Selected Local Area Vaccination Coverage Among Adolescents Aged 13–17 Years — United States, 2019 journal August 2020
Prevalence of Anogenital Warts Among Participants in Private Health Plans in the United States, 2003–2010: Potential Impact of Human Papillomavirus Vaccination journal August 2013
Declines in Anogenital Warts Among Age Groups Most Likely to Be Impacted by Human Papillomavirus Vaccination, United States, 2006–2014 journal January 2018

Similar Records

Prevalence of human papillomavirus genotypes in high-grade cervical precancer and invasive cervical cancer from cancer registries before and after vaccine introduction in the United States
Journal Article · Tue Jul 20 20:00:00 EDT 2021 · Cancer (Philadelphia) · OSTI ID:1981396
Trends in HPV- and non-HPV-associated vulvar cancer incidence, United States, 2001–2017
Journal Article · Tue Oct 11 20:00:00 EDT 2022 · Preventive Medicine · OSTI ID:2425830

Related Subjects

60 APPLIED LIFE SCIENCES
environmental health
general medicine
internal medicine
occupational health
public