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Heterogeneity and Recombination of Foot-and-Mouth Disease Virus during Multi-Strain Coinfection of Cattle

Journal Article · · mSphere
 [1];  [1];  [2];  [3]
  1. United States Department of Agriculture, Greenport, NY (United States); Kansas State University, Manhattan, KS (United States)
  2. United States Department of Agriculture, Greenport, NY (United States); Oak Ridge Institute for Science and Education (ORISE), Oak Ridge, TN (United States)
  3. United States Department of Agriculture, Greenport, NY (United States)
+ Show Author Affiliations
Superinfection of cattle persistently infected with foot-and-mouth disease virus (FMDV), with a heterologous FMDV strain has been shown to generate novel recombinant viruses. In this study, we investigated the pathogenesis events within specific tissues associated with FMDV coinfections in cattle subjected to either simultaneous or serial exposure to two distinct strains of FMDV. Both strains of FMDV (one each of serotypes O and A) were similarly localized to the nasopharyngeal mucosa during the early stages of infection. However, while no recombinant FMDV genomes were recovered from simultaneously coinfected cattle, interserotypic recombinants were isolated from nasopharyngeal tissue samples obtained at 48 h after heterologous superinfection of a persistently infected FMDV carrier. Additionally, analysis of FMDV genomes obtained from replicate nasopharyngeal tissue samples demonstrated that adjacent segments of the mucosa were sometimes infected by distinct viruses, demonstrating a multifocal and heterogeneous distribution of FMDV infection during primary and persistent phases of infection. Furthermore, this work indicates that superinfection of FMDV carriers may be an important source of emergent recombinant strains of FMDV in areas where multiple strains are co-circulating.
Research Organization:
Oak Ridge Institute for Science and Education (ORISE), Oak Ridge, TN (United States)
Sponsoring Organization:
USDOE Office of Science (SC)
Grant/Contract Number:
SC0014664
OSTI ID:
2425695
Journal Information:
mSphere, Journal Name: mSphere Journal Issue: 3 Vol. 8; ISSN 2379-5042
Publisher:
American Society for MicrobiologyCopyright Statement
Country of Publication:
United States
Language:
English

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Related Subjects

60 APPLIED LIFE SCIENCES
FMD
FMDV
Microbiology
cattle
foot-and-mouth disease
foot-and-mouth disease virus
infectious disease
pathogenesis
recombination