Optimizing Strategies for Bio-Based Ethanol Production Using Genome-Scale Metabolic Modeling of the Hyperthermophilic Archaeon, Pyrococcus furiosus

Vailionis, Jason L.; Zhao, Weishu; Zhang, Ke; Rodionov, Dmitry A.; Lipscomb, Gina L.; Tanwee, Tania N.  N.; O'Quinn, Hailey C.; Bing, Ryan G.; Kelly, Robert M.; Adams, Michael W.  W.; Zhang, Ying; Atomi, Haruyuki

doi:10.1128/aem.00563-23

Optimizing Strategies for Bio-Based Ethanol Production Using Genome-Scale Metabolic Modeling of the Hyperthermophilic Archaeon, Pyrococcus furiosus

Journal Article · Wed Jun 28 00:00:00 EDT 2023 · Applied and Environmental Microbiology

DOI:https://doi.org/10.1128/aem.00563-23· OSTI ID:2421245

Vailionis, Jason L. ^[1]; Zhao, Weishu ^[2]; Zhang, Ke ^[2]; Rodionov, Dmitry A. ^[3]; Lipscomb, Gina L. ^[4]; Tanwee, Tania N. N. ^[4]; O'Quinn, Hailey C. ^[4]; Bing, Ryan G. ^[5]; ^[5]; ^[4]; ^[2]; Atomi, Haruyuki

Department of Cell and Molecular Biology, College of the Environment and Life Sciences, University of Rhode Island, Kingston, Rhode Island, USA; OSTI
Department of Cell and Molecular Biology, College of the Environment and Life Sciences, University of Rhode Island, Kingston, Rhode Island, USA
Sanford-Burnham-Prebys Medical Discovery Institute, La Jolla, California, USA
Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, USA
Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina, USA

The bio-based production of organic chemicals provides a sustainable alternative to fossil-based production in the face of today’s climate challenges. In this work, we present a genome-scale metabolic reconstruction ofPyrococcus furiosus, a well-established platform organism that has been engineered to produce a variety of chemicals and fuels.

View Accepted Manuscript (DOE)

Research Organization:: Univ. of Georgia, Athens, GA (United States)

Sponsoring Organization:: USDOE Office of Science (SC)

Grant/Contract Number:: SC0019391; SC0022192

OSTI ID:: 2421245

Journal Information:: Applied and Environmental Microbiology, Journal Name: Applied and Environmental Microbiology Journal Issue: 6 Vol. 89; ISSN 0099-2240

Publisher:: American Society for MicrobiologyCopyright Statement

Country of Publication:: United States

Language:: English

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