Lead induced thyroid dysfunction and lipid peroxidation in the fish Clarias batrachus with special reference to hepatic type I-5{prime}-monodeiodinase activity

Journal Article · Mon Apr 01 04:00:00 EST 1996 · Bulletin of Environmental Contamination and Toxicology

DOI:https://doi.org/10.1007/s001289900095· OSTI ID:241243

Chaurasia, S S; Gupta, P; Kar, A ^[1]

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1. Devi Ahilya Univ., Indore (India); and others

Lead in high concentration has been well recognized as a cumulative general metabolic poison. The toxic effects of lead poisoning in fishes have been reviewed from time to time with reference to both hematological and biochemical variables. In this group of vertebrates lead is known to inhibit neural activity and perhaps the reproductive behavior patterns. However, very little is known about the effect of lead on endocrine physiology, particularly on thyroid function in fish. One considering {sup 131}I uptake by thyroid and other involving estimation of circulating thyroxine (T{sub 3}) only and not Triiodothyronine (T{sub 3}) which is known to be biologically more potent. The principal pathway of T{sub 3} generation is the peripheral monodeiodination of T{sub 4} which is primarily catabolised by the enzyme, Type I 5`-monodeiodinase, which has not been studied in relation to lead toxicity in fish. Therefore, in the present investigation, a systematic study has been made to evaluate the chronic effects of lead nitrate in circulating T{sub 3} and T{sub 4} concentrations along with the hepatic lipid peroxidation (LPO) in Clarias batrachus. Mode of action of lead rendering thyroid dysfunction has also been worked out by estimating Hepatic Type I 5`- monodeiodinase (5`-D) enzyme activity. 17 refs., 3 figs.

• OSTI ID: 241243
• Journal Information: Bulletin of Environmental Contamination and Toxicology, Journal Name: Bulletin of Environmental Contamination and Toxicology Journal Issue: 4 Vol. 56; ISSN 0007-4861; ISSN BECTA6
• Country of Publication: United States
• Language: English

Related Subjects

56 BIOLOGY AND MEDICINE
APPLIED STUDIES
BIOLOGICAL EFFECTS
FISHES
LEAD
PHYSIOLOGY