Mapping the human corticotropin releasing hormone binding protein gene (CRHBP) to the long arm of chromosome 5 (5q11.2-q13.3)

Journal Article · Sun Jan 01 04:00:00 EST 1995 · Genomics

DOI:https://doi.org/10.1016/0888-7543(95)80151-B· OSTI ID:241104

Vamvakopoulos, N C ^[1]; Sioutopoulou, T O ^[2]; Durkin, S A ^[3]

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1. Univ. of Thessaly School of Medicine, Larisa (Greece)
2. Univ. of Athens Medical School (Greece)
3. American Type Culture Collection, Rockville, MD (United States)

Unexpected stimulation or stress activates the heat shock protein (hsp) system at the cellular level and the hypothalamic-pituitary-adrenal (HPA) axis at the level of the whole organism. At the molecular level, these two systems communicate through the functional interaction between hsp90 and glucocorticoid receptor (GR). The corticotropin releasing hormone (CRH) system regulates the mammalian stress response by coordinating the activity of the HPA axis. It consists of the 41-amino-acid-long principal hypothalamic secretagogue for pituitary adrenocorticotropic hormone (ACTH), CRH, its receptor (CRHR), and its binding protein (CRHBP). Because of its central role in the coordination of stress response and whole body homeostasis, the CRH system has been implicated in the pathogenesis of neuroendocrine and psychiatric disease. 19 refs., 1 fig.

• OSTI ID: 241104
• Journal Information: Genomics, Journal Name: Genomics Journal Issue: 1 Vol. 25; ISSN 0888-7543; ISSN GNMCEP
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
ENDOCRINE DISEASES
GENES
GENETIC MAPPING
HORMONES
HUMAN CHROMOSOME 5
MENTAL DISORDERS
POLYMERASE CHAIN REACTION
PROTEINS