A novel C{sub 2}H{sub 2} zinc-finger protein gene (ZNF160) maps to human chromosome 19q13.3-q13.4

Journal Article · Sun Jan 01 04:00:00 EST 1995 · Genomics

DOI:https://doi.org/10.1016/0888-7543(95)80149-G· OSTI ID:241102

Halford, S; Daw, S; Scambler, P J ^[1]

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1. Inst. of Child Health, London (United Kingdom); and others

The human genome may contain up to 400 genes encoding zinc-finger (ZNF) proteins; a high proportion of those mapped have been localized to human chromosome 19. Heubner and colleagues have mapped 6 cDNAs containing a ZNF motif to 19q, and one to 19p, using somatic cell hybrids. Ten further sequences were regionally assigned by Lichter and colleagues, with a retinoic acid inducible ZNF gene being mapped to 19q13.2-q13.4. Thirty-nine cosmids identified on the basis of cross-hybridization to a ZNF {open_quotes}linker{close_quotes} sequence were mapped by FISH, 24 mapping to 19p and 15 to 19q. However, it is not known which of these sequences are transcribed or encode the cDNAs mentioned above. Forty Kruppel C{sub 2}H{sub 2}-related genes have been mapped to a cluster on 19p12-p13.1. It is interesting that none of these genes is detectable in the mouse or rat genomes, suggesting a relatively recent evolutionary origin for this cluster. 12 refs., 1 fig.

• OSTI ID: 241102
• Journal Information: Genomics, Journal Name: Genomics Journal Issue: 1 Vol. 25; ISSN 0888-7543; ISSN GNMCEP
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
BIOLOGICAL EVOLUTION
COSMIDS
DNA HYBRIDIZATION
DNA SEQUENCING
FLUORESCENCE
GENES
GENETIC MAPPING
HUMAN CHROMOSOME 19
HYBRIDIZATION
PROTEINS
SOMATIC CELLS