Assignment of the 36.5-kDa (RFC5), 37-kDa (RFC4), 38-kDa (RFC3), and 40-kDa (RFC2) subunit genes of human replication factor C to chromosome bands 12q24.2-q24.3, 3q27, 13q12.3-q13, and 7q11.23
- Inst. of Physical and Chemical Research, Ibaraki (Japan); and others
Replication factor C is a multimeric primer-recognition protein consisting of five subunits and is essential for the processive elongation of DNA chains catalyzed by DNA polymerase {delta} or {epsilon} in human cells. We have mapped the locations on human chromosomes of the genes coding for the four smaller subunits using both PCR amplification from DNAs of a panel of somatic hybrids and fluorescence in situ hybridization to bands 12q24.2-q24.3, 3q27, 13q12.3-q13, and 7q11.23, respectively. 14 refs., 2 figs., 1 tab.
- OSTI ID:
- 241088
- Journal Information:
- Genomics, Journal Name: Genomics Journal Issue: 1 Vol. 25; ISSN 0888-7543; ISSN GNMCEP
- Country of Publication:
- United States
- Language:
- English
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