A 500-kilobase region containing the tuberous sclerosis locus (TSC1) in a 1.7-megabase YAC and cosmid contig
- Harvard Medical School, Boston, MA (United States); and others
A complete overlapping clone map of a 1.7-Mb region from DBH to D9S67 that includes the TSC1 candidate region has been constructed. The map includes YAC and cosmid clones, contains STS approximately every 50 kb on average, and establishes the order of five previously unordered loci. The overall physical length of this segment of chromosome 9q34 (1.7 Mb) is significantly less than expected compared to its estimated genetic length ({approximately}10 cM). Consequently, the physical length of the TSC1 candidate region is substantially less than predicted by a genetic distance of {approximately}2 cM. 14 refs., 1 fig., 2 tabs.
- OSTI ID:
- 241066
- Journal Information:
- Genomics, Journal Name: Genomics Journal Issue: 1 Vol. 25; ISSN GNMCEP; ISSN 0888-7543
- Country of Publication:
- United States
- Language:
- English
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