Neuroinflammation is dependent on sex and ovarian hormone presence following acute woodsmoke exposure

Wardhani, Kartika; Yazzie, Sydnee; Edeh, Onamma; Grimes, Martha; Dixson, Connor; Jacquez, Quiteria; Zychowski, Katherine E.

doi:10.1038/s41598-024-63562-2

Neuroinflammation is dependent on sex and ovarian hormone presence following acute woodsmoke exposure

Journal Article · Thu Jun 06 00:00:00 EDT 2024 · Scientific Reports

DOI:https://doi.org/10.1038/s41598-024-63562-2· OSTI ID:2406670

Wardhani, Kartika ^[1]; Yazzie, Sydnee ^[2]; Edeh, Onamma ^[2]; Grimes, Martha ^[2]; Dixson, Connor ^[2]; Jacquez, Quiteria ^[2]; Zychowski, Katherine E. ^[2]

Univ. of New Mexico, Albuquerque, NM (United States); Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
Univ. of New Mexico, Albuquerque, NM (United States)

Woodsmoke (WS) exposure is associated with significant health-related sequelae. Different populations can potentially exhibit varying susceptibility, based on endocrine phenotypes, to WS and investigating neurological impacts following inhaled WS is a growing area of research. In this study, a whole-body inhalation chamber was used to expose both male and female C57BL/6 mice (n = 8 per group) to either control filtered air (FA) or acute WS (0.861 ± 0.210 mg/m³) for 4 h/d for 2 days. Neuroinflammatory and lipid-based biological markers were then assessed. In a second set of studies, female mice were divided into two groups: one group was ovariectomized (OVX) to simulate an ovarian hormone-deficient state (surgical menopause), and the other underwent Sham surgery as controls, to mechanistically assess the impact of ovarian hormone presence on neuroinflammation following FA and acute WS exposure to simulate an acute wildfire episode. There was a statistically significant impact of sex (P ≤ 0.05) and statistically significant interactions between sex and treatment in IL-1β, CXCL-1, TGF-β, and IL-6 brain relative gene expression. Hippocampal and cortex genes also exhibited significant changes in acute WS-exposed Sham and OVX mice, particularly in TGF-β (hippocampus) and CCL-2 and CXCL-1 (cortex). Cortex GFAP optical density (OD) showed a notable elevation in male mice exposed to acute WS, compared to the control FA. Sham and OVX females demonstrated differential GFAP expression, depending on brain region. Overall, targeted lipidomics in phosphatidylcholine (PC) and phosphatidylethanolamine (PE) serum and brain lipids demonstrated more significant changes between control FA and acute WS exposure in female mice, compared to males. In summary, male and female mice show distinct neuroinflammatory markers in response to acute WS exposure. Furthermore, ovarian hormone deficiency may impact the neuroinflammatory response following an acute WS event.

View Accepted Manuscript (DOE)

Research Organization:: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

Sponsoring Organization:: National Institutes of Health (NIH); USDOE National Nuclear Security Administration (NNSA)

Grant/Contract Number:: 89233218CNA000001

OSTI ID:: 2406670

Report Number(s):: LA-UR--24-25278

Journal Information:: Scientific Reports, Journal Name: Scientific Reports Journal Issue: 1 Vol. 14; ISSN 2045-2322

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United States

Language:: English

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59 BASIC BIOLOGICAL SCIENCES
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sex-differences
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