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Production of Astatine-211 for Translational Science in Radiotherapy (Research Performance Progress Report)

Technical Report ·
DOI:https://doi.org/10.2172/2329303· OSTI ID:2329303
 [1];  [2];  [2]; ;  [3];  [2];  [2]
  1. Univ. of Pennsylvania, Philadelphia, PA (United States); University of Pennsylvania
  2. Univ. of Pennsylvania, Philadelphia, PA (United States)
  3. Erasmus University, Rotterdam (The Netherlands)
+ Show Author Affiliations
In this proposal we outline the methods to improve the isotope production of astatine-211 at the University of Pennsylvania Cyclotron Facility. Astatine-211 is an isotope that emits alpha- radiation and has high potential for treating otherwise untreatable cancers. The goal of this proposal is two fold, 1) Optimize current production of astatine-211 and maintain routine production and 2) develop new isotope production target systems and chemical isolation systems. By completing this proposal we will ensure that the University of Pennsylvania Cyclotron Facility continues to build it’s isotope program in an effort that unites under DOE isotope network supply initiatives with the overall goal of increasing the national supply of isotopes. The University of Pennsylvania is uniquely located in the northeast corridor of the United States of America and has access to dozens of institutions that could use astatine-211 in their research. With the support of the DOE we have the opportunity to provide additional momentum to this growing field of research and will be able to provide the foundation for economical development of astatine-211 research and application in medicine.
Research Organization:
Univ. of Pennsylvania, Philadelphia, PA (United States)
Sponsoring Organization:
USDOE Office of Science (SC), Office of Isotope R&D and Production (IRP)
DOE Contract Number:
SC0021066
OSTI ID:
2329303
Report Number(s):
DOE-PENN--0021066
Country of Publication:
United States
Language:
English

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Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE