Chromosomal localization of the human prostanoid receptor gene family

Journal Article · Fri Feb 10 04:00:00 EST 1995 · Genomics

DOI:https://doi.org/10.1016/0888-7543(95)80022-E· OSTI ID:232726

Duncan, A M.V.; Anderson, L L ^[1]; Funk, C D ^[2]

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1. Queen`s Univ., Kingston, Ontario (Canada)
2. Vanderbilt Univ., Nashville, TN (United States); and others

Prostaglandins (PGD{sub 2}, PGE{sub 2}, PGF{sub 2{alpha}}, and PGI{sub 2}) and thromboxane A{sub 2} (TXA{sub 2}) are biologically active molecules derived from the metabolism of arachidonic acid by cyclooxygenases. They produce a wide variety of physiological and pathophysiological effects mediated through specific G protein-coupled cell surface receptors. In this study, we have mapped the chromosomal positions of the human genes that encode the PGE{sub 2} receptor subtypes (PTGER1, PTGER2, and PTGER3), the PGF{sub 2{alpha}} receptor (PTGFR), the PGI{sub 2} receptor (PTGIR), and the TXA{sub 2} receptor (TBXA2R) using in situ hybridization. The PTGER1, TBXA2R, and PTGIR genes mapped to chromosome 19 at positions 19p13.1, 19p13.3, and 19q13.3, respectively. The PTGFR and PTGER3 genes mapped to chromosome 1 at positions 1p31.1 and 1p31.2, respectively, and PTGER2 gene mapped to chromosome band 5p13.1. 16 refs., 1 tab.

• OSTI ID: 232726
• Journal Information: Genomics, Journal Name: Genomics Journal Issue: 3 Vol. 25; ISSN GNMCEP; ISSN 0888-7543
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
DNA HYBRIDIZATION
GENES
GENETIC MAPPING
HUMAN CHROMOSOME 1
HUMAN CHROMOSOME 19
HUMAN CHROMOSOME 5
PROBES
PROSTAGLANDINS
RECEPTORS