Establishment of Microbeam Radiation Therapy at a Small-Animal Irradiator

Journal Article · Mon Feb 15 04:00:00 EST 2021 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/J.IJROBP.2020.09.039· OSTI ID:23198664

Treibel, Franziska ^[1]; Nguyen, Mai ^[1]; Ahmed, Mabroor ^[1]; Dombrowsky, Annique ^[1]; Wilkens, Jan J. ^[1]; Combs, Stephanie E.; Schmid, Thomas E. ^[1]; Bartzsch, Stefan ^[1]

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1. School of Medicine, Klinikum rechts der Isar, Department of Radiation Oncology, Technical University of Munich, Munich (Germany)

Microbeam radiation therapy is a preclinical concept in radiation oncology. It spares normal tissue more effectively than conventional radiation therapy at equal tumor control. The radiation field consists of peak regions with doses of several hundred gray, whereas doses between the peaks (valleys) are below the tissue tolerance level. Widths and distances of the beams are in the submillimeter range for microbeam radiation therapy. A similar alternative concept with beam widths and distances in the millimeter range is presented by minibeam radiation therapy. Although both methods were developed at large synchrotron facilities, compact alternative sources have been proposed recently.

• OSTI ID: 23198664
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Journal Name: International Journal of Radiation Oncology, Biology and Physics Journal Issue: 2 Vol. 109; ISSN IOBPD3; ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL TISSUES
ANIMALS
BEAM PROFILES
LEVEL WIDTHS
NEOPLASMS
RADIATION DOSES
RADIOTHERAPY
SYNCHROTRONS
TOLERANCE