Study on the preparation of holmium-166 patch for skin cancer treatment
- Korea Atomic Energy Research Institute, P.O. Box 105, Yusung, Taejon 305-600 (Korea, Republic of)
- Yonsei Medical School, 134, Shincheon-Dong, SudaemoonGu Seoul (Korea, Republic of)
- Dong Wha Pharmaceutical Company, 189, Anyang-Dong, Anyang-City, Kyunggi-Do (Korea, Republic of)
A radioactive patch containing holmium-166 bas been developed for skin cancer treatment. The flexible nonradioactive {sup 165}Ho-film was prepared by dissolving polyurethane and {sup 165}Ho(NO{sub 3}){sub 3}. 5H{sub 2}O in a solvent mixture of DMF and THF, and subsequently extruding the mixture on an aluminum dish and air drying it. The resulting {sup 165}Ho-film was easily converted to radioactive flexible {sup 166}Ho-film by neutron irradiation in the 'HANARO' research reactor. The radioactive patch practically applicable to the treatment of the superficial skin cancer without using any adhesive agent could be prepared as a sandwich type patch by inserting the {sup 166}Ho-film between two polyester film layers. The absorbed dose rates in skin by the {sup 166}Ho-patch were computed by means of the EGS4 code system. Air and liquid water were used as transport materials. The number of histories was chosen as 40,000,000. The source was based on the disk type of {sup 166}Ho-patch, and the target was designed to be a 0.5 mm height cylinder with the same diameter as that of the source. The dose rate distributions were obtained for source diameters ranging from 10-50 mm in 10 mm steps. The estimated dose rates for 37 MBq of five {sup 166}Ho-patch sources in the increasing order of source diameter were 1.248 cGy/s(0. 96%), 0.324 cGy/s(0.83%), 0.145 cGy/s(0.92%), 0.082 cGy/s(0.93%), 0.053 cGy/s(1.02%) at a 0.5 mm target depth, respectively. On the basis of above results, the initial activity and irradiation period were determined so that the total absorbed dose for the treatment of squamous cell carcinoma was found to be 70-75 Gy. The disk type of the {sup 166}Ho-patch was applied to animal models and patients with malignant skin cancer. Their efficacy and safety have been investigated for several months. Skin tumors could be successfully treated with the {sup 166}Ho-patch in animal models and patients. The ease with which the {sup 166}Ho-patch can be prepared in various types, and also its safety and effectiveness, make it an attractive device for skin cancer treatments.
- Research Organization:
- American Nuclear Society - ANS, 555 North Kensington Avenue, La Grange Park, IL 60526 (United States)
- OSTI ID:
- 23142237
- Resource Relation:
- Conference: Global'99: International Conference on Future Nuclear Systems - Nuclear Technology - Bridging the Millennia, Las Vegas, NV (United States), 29 Aug - 3 Sep 1999; Other Information: Country of input: France; 7 refs.; available from American Nuclear Society - ANS, 555 North Kensington Avenue, La Grange Park, IL 60526 (US)
- Country of Publication:
- United States
- Language:
- English
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