Regulation of hair follicle development by exosomes derived from dermal papilla cells
Journal Article
·
· Biochemical and Biophysical Research Communications
- Department of Dermatology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou (China)
Highlights: • Exosomes derived from DPCs (DPC-Exos) significantly induced anagen while delaying catagen in mice. • DPC-Exos enhanced the proliferation and migration of outer root sheath cells in vitro. • These effects of DPC-Exos were mediated by β-catenin and Sonic hedgehog signaling. Dermal papilla cells (DPCs) play a critical role in the regulation of hair follicle (HF) growth, formation, and cycling. DPCs are thought to regulate HF growth through a paracrine mechanism, in which exosomes may play a critical role.
- OSTI ID:
- 23137125
- Journal Information:
- Biochemical and Biophysical Research Communications, Journal Name: Biochemical and Biophysical Research Communications Journal Issue: 2 Vol. 500; ISSN BBRCA9; ISSN 0006-291X
- Country of Publication:
- United States
- Language:
- English
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