Circular RNA hsa{sub c}irc{sub 0}008039 promotes breast cancer cell proliferation and migration by regulating miR-432-5p/E2F3 axis

Journal Article · Sun Jul 15 04:00:00 EDT 2018 · Biochemical and Biophysical Research Communications

DOI:https://doi.org/10.1016/J.BBRC.2018.05.166· OSTI ID:23136967

Liu, Yanhua ^[1]; Lu, Cuntao ^[2]; Zhou, Yizhou ^[3]; Zhang, Zhihong ^[1]; Sun, Li ^[3]

---

1. Department of Pathology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029 (China)
2. Department of Breast Surgery, Xuzhou Central Hospital, Xuzhou 221009 (China)
3. Department of Medical Oncology, Xuzhou Central Hospital, Xuzhou 221009 (China)

As the development of sequencing technology, more and more circular RNAs (circRNAs) are identified in human cancer tissues. Increasing evidences imply circRNAs are important regulators in tumor progression. Nevertheless, how circRNAs participate in breast cancer development and progression is not well understood. In the present study, we identified a novel circRNA hsa{sub c}irc{sub 0}008039 with upregulated expression level in breast cancer tissues. By functional experiments, we found that hsa{sub c}irc{sub 0}008039 depletion significantly suppressed the proliferation, arrested cell-cycle progression and reduced migration in breast cancer. Mechanistic investigations suggested that hsa{sub c}irc{sub 0}008039 served as a competing endogenous RNA (ceRNA) of miR-432-5p. Subsequently, E2F3 was identified as the functional target of miR-432-5p and overexpression of hsa{sub c}irc{sub 0}008039 elevated E2F3 expression in breast cancer. On the whole, our study indicated that hsa{sub c}irc{sub 0}008039 exerted oncogenic roles in breast cancer and suggested the hsa{sub c}irc{sub 0}008039/miR-432-5p/E2F3 axis might be a potential therapeutic target.

• OSTI ID: 23136967
• Journal Information: Biochemical and Biophysical Research Communications, Journal Name: Biochemical and Biophysical Research Communications Journal Issue: 3 Vol. 502; ISSN BBRCA9; ISSN 0006-291X
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
CELL CYCLE
CELL PROLIFERATION
MAMMARY GLANDS
NEOPLASMS
RNA