Sono-photodynamic modality for cancer treatment using bio-degradable bio-conjugated sonnelux nanocomposite in tumor-bearing mice: Activated cancer therapy using light and ultrasound

Journal Article · Sat Sep 15 00:00:00 EDT 2018 · Biochemical and Biophysical Research Communications

DOI:https://doi.org/10.1016/J.BBRC.2018.06.119· OSTI ID:23105628

Abd El-Kaream, Samir Ali, E-mail: [e-mail] ^[1]; Abd Elsamie, Gihan Hosny, E-mail: [e-mail] ^[2]; Abd-Alkareem, Azhar Salim, E-mail: [e-mail] ^[2]; B.Sc. of Biochemical Technology, University of Technology-Baghdad ^[3]

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1. Department of Applied Medical Chemistry, Medical Research Institute, Alexandria University (Egypt)
2. Department of Public Health & Occupational Medicine, Institute of Graduate Studies and Research, Alexandria University (Egypt)
3. (Iraq)

Highlights: • An up-to-date cancer therapy: Sono-photodynamic therapy (SPDT) in combination with sonnelux (SLux) as a sono-photosensitizer loaded on folic acid conjugated nanographene oxide nanoparticles (FA-NGO- SLux). • A novel nanomaterial with great potential as effective drug delivery system in targeting sono-photo-dynamic-therapy (SPDT). The underlying work was conducted aiming at cancer targeted therapy using the sono-photodynamic therapy (SPDT) in combination with sonnelux (SLux) as a sono-photosensitizer loaded on folic acid conjugated nanographene oxide nanoparticles (FA-NGO-SLux) as an up-to-date treating cancer modality. Study was conducted on A total of 130 male Swiss albino mice with age 60–65 day, weighing 20 ± 25 g, inoculated with Ehrlich ascites carcinoma (EAC) subdivided into 13 group. Two sources of energy were used; namely infrared laser and Ultrasound (pulsed and continuous wave mode). Results revealed that Nano-SLux is a potential photosensitizer and sonosensitizer for photodynamic or sonodynamic treatment of Ehrlich ascites tumor tissue. Nano-SLux can play important roles in inhibiting tumor growth and even inducing cell death, which might be attributed to Photo and/or sono-chemical activation mechanism. Infra-red laser in combination with ultrasound in the presence of Nano- SLux has a potential antitumor effect. Sonocation followed by light photon irradiation proves its excellent efficiency as an anticancer therapy. The results suggest that folic acid-conjugated nano-graphene oxide loaded with sono-photo-sensitizers (FA–NGO–SPSs) could be used as a novel nanomaterial with great potential as effective drug delivery system in targeting sono-photo-dynamic-therapy (SPDT).

• OSTI ID: 23105628
• Journal Information: Biochemical and Biophysical Research Communications, Vol. 503, Issue 2; Other Information: Copyright (c) 2018 Published by Elsevier Inc.; Country of input: International Atomic Energy Agency (IAEA); ISSN 0006-291X
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
EHRLICH ASCITES TUMOR
FOLIC ACID
NANOCOMPOSITES
NANOPARTICLES
PHOTODYNAMIC THERAPY