SPION@APTES@FA-PEG@Usnic Acid Bionanodrug for Cancer Therapy
- Gama Mechatronics Company (Turkey)
- Istanbul University, Faculty of Engineering, Department of Chemistry (Turkey)
- University of Dammam, Department of Nano-Medicine Research, Institute for Research and Medical Consultations (IRMC) (Saudi Arabia)
In this work, we aimed to develop stable usnic acid (UA)-conjugated superparamagnetic iron oxide nanoparticles (SPIONs) as a potential drug carrier for in vitro analysis of MCF-7 (breast cancer cell line), HeLa (cervix cancer cell line), L929 (mouse fibroblast cell line), U87 (glioblastoma cell line, brain cancer), and A549 (human lung cancer cell line) cell lines. SPIONs were synthesized via the polyol method and functionalized with APTES using the Stöber method. Carboxylated polyethylene glycol (PEG-COOH), folic acid (FA), and carboxylated luteolin (CL) were conjugated on the surface via a carboxylic/amine group using the nanoprecipitation method, respectively. X-ray powder diffraction analysis confirmed the purity of the product with crystallite size of around 11 nm. Fourier-transformed infrared spectrophotometer (FT-IR) analyses explained the conjugation of all functional groups to the surface of SPIONs. The percentages of inorganic and organic content in the products were investigated via thermal gravimetric analyzer (TGA). For morphological analysis, a transmission electron microscope (TEM) was used. The superparamagnetic property of the product was also confirmed by vibrating sample magnetometer (VSM).
- OSTI ID:
- 22771329
- Journal Information:
- Journal of Superconductivity and Novel Magnetism, Journal Name: Journal of Superconductivity and Novel Magnetism Journal Issue: 5 Vol. 31; ISSN 1557-1939
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
75 CONDENSED MATTER PHYSICS
SUPERCONDUCTIVITY AND SUPERFLUIDITY
DRUG DELIVERY
FIBROBLASTS
FOLIC ACID
FOURIER TRANSFORM SPECTROMETERS
IN VITRO
IRON OXIDES
MAGNETIC PROPERTIES
MAMMARY GLANDS
NANOPARTICLES
POLYETHYLENE GLYCOLS
SPECTROPHOTOMETERS
SUPERPARAMAGNETISM
THERAPY
THERMAL GRAVIMETRIC ANALYSIS
TRANSMISSION ELECTRON MICROSCOPY
VIBRATING SAMPLE MAGNETOMETERS
X-RAY DIFFRACTION