Environmental chemicals and breast cancer: An updated review of epidemiological literature informed by biological mechanisms
Journal Article
·
· Environmental Research
Highlights: • Chemicals that cause mammary tumors in animals also influence breast cancer risk. • Few studies assessed exposure in biologically relevant times of breast development. • Studies of early life exposure show risk for some OCPs, air pollution and solvents. • Genetic variants may modify breast cancer risk associated with PAH exposure. Many common environmental chemicals are mammary gland carcinogens in animal studies, activate relevant hormonal pathways, or enhance mammary gland susceptibility to carcinogenesis. Breast cancer’s long latency and multifactorial etiology make evaluation of these chemicals in humans challenging.
- OSTI ID:
- 23100731
- Journal Information:
- Environmental Research, Journal Name: Environmental Research Vol. 160; ISSN ENVRAL; ISSN 0013-9351
- Country of Publication:
- United States
- Language:
- English
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