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Title: Pesticides and polychlorinated biphenyl residues in human breast lipids and their relation to breast cancer

Abstract

The etiology of human breast cancer is unknown; accepted risk factors, e.g., menstrual, reproductive, and family histories, are implicated in less than half of all cases. Various halogenated hydrocarbons - acting as either co-carcinogens or promoting agents - which are derived from the environment and are concentrated in human fatty stores, may also play a role in breast cancer risk. A pilot study was undertaken to measure and compare levels of chemical residues in mammary adipose tissue from women with malignant and nonmalignant breast disease. Elevated levels of polychlorinated biphenyls, bis (4-chlorophenyl)-1,1 dichloroethene, and bis(4-chlorophenyl)-1,1,1 trichloroethane were found in fat samples from women with cancer, compared with those who had benign breast disease. These results, although preliminary, suggest a role for environmentally derived suspect carcinogens in the genesis of mammary carcinoma.

Authors:
 [1]; ;  [2]; ;  [3]
  1. (Univ. of Michigan, Ann Arbor (United States))
  2. (Hartford Hospital, CT (United States))
  3. (Mount Sinai School of Medicine, New York, NY (United States))
OSTI Identifier:
5172468
Alternate Identifier(s):
OSTI ID: 5172468
Resource Type:
Journal Article
Resource Relation:
Journal Name: Archives of Environmental Health; (United States); Journal Volume: 47:2
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CHLORINATED AROMATIC HYDROCARBONS; HEALTH HAZARDS; MAMMARY GLANDS; NEOPLASMS; ETIOLOGY; PESTICIDES; CARCINOGENESIS; ESTROGENS; RISK ASSESSMENT; AROMATICS; BODY; DISEASES; GLANDS; HALOGENATED AROMATIC HYDROCARBONS; HAZARDS; HORMONES; ORGANIC CHLORINE COMPOUNDS; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANS; PATHOGENESIS; STEROID HORMONES 560300* -- Chemicals Metabolism & Toxicology

Citation Formats

Falck, F. Jr., Ricci, A. Jr., Deckers, P., Wolff, M.S., and Godbold, J. Pesticides and polychlorinated biphenyl residues in human breast lipids and their relation to breast cancer. United States: N. p., Web.
Falck, F. Jr., Ricci, A. Jr., Deckers, P., Wolff, M.S., & Godbold, J. Pesticides and polychlorinated biphenyl residues in human breast lipids and their relation to breast cancer. United States.
Falck, F. Jr., Ricci, A. Jr., Deckers, P., Wolff, M.S., and Godbold, J. . "Pesticides and polychlorinated biphenyl residues in human breast lipids and their relation to breast cancer". United States. doi:.
@article{osti_5172468,
title = {Pesticides and polychlorinated biphenyl residues in human breast lipids and their relation to breast cancer},
author = {Falck, F. Jr. and Ricci, A. Jr. and Deckers, P. and Wolff, M.S. and Godbold, J.},
abstractNote = {The etiology of human breast cancer is unknown; accepted risk factors, e.g., menstrual, reproductive, and family histories, are implicated in less than half of all cases. Various halogenated hydrocarbons - acting as either co-carcinogens or promoting agents - which are derived from the environment and are concentrated in human fatty stores, may also play a role in breast cancer risk. A pilot study was undertaken to measure and compare levels of chemical residues in mammary adipose tissue from women with malignant and nonmalignant breast disease. Elevated levels of polychlorinated biphenyls, bis (4-chlorophenyl)-1,1 dichloroethene, and bis(4-chlorophenyl)-1,1,1 trichloroethane were found in fat samples from women with cancer, compared with those who had benign breast disease. These results, although preliminary, suggest a role for environmentally derived suspect carcinogens in the genesis of mammary carcinoma.},
doi = {},
journal = {Archives of Environmental Health; (United States)},
number = ,
volume = 47:2,
place = {United States},
year = {},
month = {}
}