A study of telomere length, arsenic exposure, and arsenic toxicity in a Bangladeshi cohort

Journal Article · Sun Jul 15 04:00:00 EDT 2018 · Environmental Research

DOI:https://doi.org/10.1016/J.ENVRES.2018.03.005· OSTI ID:23095634

Zhang, Chenan ^[1]; Kibriya, Muhammad G.; Jasmine, Farzana ^[1]; Roy, Shantanu ^[1]; Gao, Jianjun ^[1]; others, and

---

1. Department of Public Health Sciences, University of Chicago, Chicago, IL 60615 (United States)

Highlights: • This is the largest study to date on arsenic exposure and telomere length. • Arsenic exposure was not associated with leukocyte telomere length. • This is the first prospective study of telomere length and skin lesion risk. • Shorter telomere length was associated with greater risk of subsequent skin lesion. • Telomere length modified the effect of arsenic exposure on skin lesion risk. Chronic arsenic exposure is associated with increased risk for arsenical skin lesions, cancer, and other adverse health outcomes. One potential mechanism of arsenic toxicity is telomere dysfunction. However, prior epidemiological studies of arsenic exposure, telomere length (TL), and skin lesion are small and cross-sectional. We investigated the associations between arsenic exposure and TL and between baseline TL and incident skin lesion risk among individuals participating in the Health Effects of Arsenic Longitudinal Study in Bangladesh (2000–2009).

• OSTI ID: 23095634
• Journal Information: Environmental Research, Journal Name: Environmental Research Vol. 164; ISSN ENVRAL; ISSN 0013-9351
• Country of Publication: United States
• Language: English

Related Subjects

54 ENVIRONMENTAL SCIENCES
ARSENIC
BANGLADESH
ENVIRONMENTAL EXPOSURE
HEALTH HAZARDS
LEUKOCYTES
NEOPLASMS
SKIN
TELOMERES
TOXICITY