Development of a series of Korean pediatric and adult head computational phantoms and application to nuclear medicine dosimetry - Paper 26

Conference · Mon Sep 15 04:00:00 EDT 2014

OSTI ID:23082873

Lee, Choonik ^[1]; Lee, Ae-Kyoung; Choi, Hyung-do ^[2]; Lee, Choonsik ^[3]

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1. Department of Radiation Oncology, University of Michigan, Ann Arbor, MI (United States)
2. Electronics and Telecommunications Research Institute, Daejeon, South Korea (Korea, Republic of)
3. Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD (United States)

Over the past decades, advances in Single Photon Emission Computed Tomography (SPECT) and Positron Emission Tomography (PET) imaging techniques and an increasing number of new radiopharmaceuticals have resulted in a surge of neuroimaging applications in nuclear medicine on pediatric and adult patients. It is not feasible to directly measure the absorbed dose to the organs of the human body from nuclear medicine procedures. The formalism of the Medical Internal Radiation Dose (MIRD) committee of the Society of Nuclear Medicine has been adopted as the calculation method to estimate radiation dose to target organs from radionuclides distributed in source organs. The absorbed dose to a target organ from different types of radionuclides distributed within source organs can be estimated by the products of the time-integrated activity in each source region and organ dose conversion coefficients, called S values (Gy/MBq-s). S values are computed from a comprehensive set of Specific Absorbed Fraction (SAF), which are calculated from computational human phantoms with realistic anatomical structures coupled with Monte Carlo transport technique. The current SAF data for pediatric and adult head and brain dosimetry is based on a series of stylized computational phantoms. However, dosimetric errors caused by the unrealistic anatomy of stylized phantoms in internal dosimetry calculations have been reported by several studies. In the current study, we developed a series of realistic computational head phantoms representing 6, 9, 12, 15, and 22-year-old standard Korean males, and computed a comprehensive set of SAFs using the phantoms coupled with Monte Carlo transport technique. (authors)

• Research Organization: American Nuclear Society - ANS, 555 North Kensington Avenue, La Grange Park, IL 60526 (United States)
• OSTI ID: 23082873
• Country of Publication: United States
• Language: English

Related Subjects

61 RADIATION PROTECTION AND DOSIMETRY
62 RADIOLOGY AND NUCLEAR MEDICINE
ABSORBED RADIATION DOSES
ANATOMY
BRAIN
DOSIMETRY
HUMAN POPULATIONS
MONTE CARLO METHOD
NUCLEAR MEDICINE
PEDIATRICS
PHANTOMS
POSITRON COMPUTED TOMOGRAPHY
RADIOPHARMACEUTICALS
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY