SU-E-T-507: Internal Dosimetry in Nuclear Medicine Using GATE and XCAT Phantom: A Simulation Study

Journal Article · Mon Jun 15 04:00:00 EDT 2015 · Medical Physics

DOI:https://doi.org/10.1118/1.4924869· OSTI ID:22548545

Fallahpoor, M; Abbasi, M ^[1]; Sen, A ^[2]; Parach, A ^[3]; Kalantari, F ^[4]

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1. Tehran University of Medical Sciences, Vali-Asr Hospital, Tehran, Tehran (Iran, Islamic Republic of)
2. University of Houston, Houston, TX (United States)
3. Shahid Sadoughi University of Medical Sciences, Yazd, Yazd (Iran, Islamic Republic of)
4. UT Southwestern Medical Center, Dallas, TX (United States)

Purpose Monte Carlo simulations are routinely used for internal dosimetry studies. These studies are conducted with humanoid phantoms such as the XCAT phantom. In this abstract we present the absorbed doses for various pairs of source and target organs using three common radiotracers in nuclear medicine. Methods The GATE software package is used for the Monte Carlo simulations. A typical female XCAT phantom is used as the input. Three radiotracers 153Sm, 131I and 99mTc are studied. The Specific Absorbed Fraction (SAF) for gamma rays (99mTc, 153Sm and 131I) and Specific Fraction (SF) for beta particles (153Sm and 131I) are calculated for all 100 pairs of source target organs including brain, liver, lung, pancreas, kidney, adrenal, spleen, rib bone, bladder and ovaries. Results The source organs themselves gain the highest absorbed dose as compared to other organs. The dose is found to be inversely proportional to distance from the source organ. In SAF results of 153Sm, when the source organ is lung, the rib bone, gain 0.0730 (Kg-1) that is more than lung itself. Conclusion The absorbed dose for various organs was studied in terms of SAF and SF. Such studies hold importance for future therapeutic procedures and optimization of induced radiotracer.

• OSTI ID: 22548545
• Journal Information: Medical Physics, Journal Name: Medical Physics Journal Issue: 6 Vol. 42; ISSN 0094-2405; ISSN MPHYA6
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
61 RADIATION PROTECTION AND DOSIMETRY
ABSORBED RADIATION DOSES
BETA PARTICLES
BLADDER
BRAIN
COMPARATIVE EVALUATIONS
COMPUTER CODES
COMPUTERIZED SIMULATION
DOSIMETRY
GAMMA RADIATION
IODINE 131
KIDNEYS
LIVER
LUNGS
MONTE CARLO METHOD
NUCLEAR MEDICINE
OPTIMIZATION
OVARIES
PANCREAS
PHANTOMS
SAMARIUM 153
SKELETON
SPLEEN
TECHNETIUM 99
TRACER TECHNIQUES