Methods for lipid nanostructure investigation at neutron and synchrotron sources
Journal Article
·
· Physics of Particles and Nuclei
- Frank Laboratory of Neutron Physics, Joint Institute for Nuclear Research, Dubna, Moscow oblast (Russian Federation)
A lipid membrane is a main component of biological membranes. Contemporary bionanotechnologies use phospholipids and ceramides as basic components of drugs and cosmetic preparations. Phospholipids-based nanoparticles are used as drug carriers. Effective development of bionanotechnologies in Russia calls for creation of physical methods to diagnose the particle nanostructure which would be promising for application in pharmacology. Radiation with wavelengths of 1–10 Å is an adequate instrument for detecting the nanostructure of lipid bi- and monolayers. The review deals with methods that apply neutron scattering and synchrotron radiation for studying nanostructures of lipid membranes, phospholipid nanoparticles, and phospholipid monolayers on a water surface by techniques of diffraction, small-angle scattering, and reflectometry. The importance of the mutually complementary application of neutron and synchrotron radiation for solving urgent problems of membrane biophysics, microbiology, dermapharmacology, and bionanotechnologies is demonstrated by particular examples of studies of phospholipid membranes and ceramide-based membranes. The efficiency of development and application of new methods for solving urgent problems of biophysics is shown. The review is written on the basis of results obtained over the period of 1999–2010 at the Joint Institute for Nuclear Research (JINR) Laboratory of Neutron Physics in collaboration with the Pharmaceutical Departments of universities of France (Paris-Sud, Chatenay Malabry) and Germany (Martin Luther University, Halle). The experiments were performed at various European and Russian neutron and synchrotron sources.
- OSTI ID:
- 22975041
- Journal Information:
- Physics of Particles and Nuclei, Journal Name: Physics of Particles and Nuclei Journal Issue: 2 Vol. 42; ISSN 1063-7796
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY
72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS
77 NANOSCIENCE AND NANOTECHNOLOGY
BASES
DRUGS
EDUCATIONAL FACILITIES
MEMBRANES
NANOSTRUCTURES
NANOTECHNOLOGY
NEUTRON DIFFRACTION
NEUTRON PHYSICS
NEUTRON SOURCES
NEUTRONS
PERFORMANCE
PHOSPHOLIPIDS
SMALL ANGLE SCATTERING
SYNCHROTRON RADIATION SOURCES
72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS
77 NANOSCIENCE AND NANOTECHNOLOGY
BASES
DRUGS
EDUCATIONAL FACILITIES
MEMBRANES
NANOSTRUCTURES
NANOTECHNOLOGY
NEUTRON DIFFRACTION
NEUTRON PHYSICS
NEUTRON SOURCES
NEUTRONS
PERFORMANCE
PHOSPHOLIPIDS
SMALL ANGLE SCATTERING
SYNCHROTRON RADIATION SOURCES