Sequential and Simultaneous 4-Antenna Microwave Ablation in an Ex Vivo Bovine Liver Model

Journal Article · Tue Oct 15 04:00:00 EDT 2019 · Cardiovascular and Interventional Radiology

DOI:https://doi.org/10.1007/S00270-019-02241-6· OSTI ID:22970609

Zhang, Tian-qi ^[1]; Huang, Sen-miao ^[2]; Gu, Yang-kui ^[1]; Jiang, Xiong-ying ^[3]; Huang, Zhi-mei; Deng, Han-xia; Huang, Jin-hua ^[1]

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1. Sun Yat-sen University Cancer Center, Department of Minimally Invasive Interventional Radiology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine (China)
2. Panyu Central Hospital, Department of Oncology (China)
3. Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Department of Interventional Radiology (China)

Aims: To determine the sizes and shapes of ablation zones in 4-antenna microwave ablation in ex vivo bovine liver model under different conditions of power delivery patterns, antenna spacings, and ablation durations, for further using of multi-antenna MWA strategies in the treatment of large hepatocellular carcinoma. Methods: We tested protocols of eight ablations each on ex vivo bovine livers, involving simultaneous or sequential activation of four microwave antennas, spaced either 3 cm, 4 cm, or 5 cm apart, for either 10 or 15 min, at 60-W power. We determined the diameters, shapes, and temperatures of the ablation zones. Results: Compared to sequential power delivery, simultaneous power delivery resulted in significantly larger ablation zone diameters (P < .001). The temperatures in ablation zones were significantly higher for simultaneous than for sequential power delivery. The largest ablation diameter (7.45 ± 0.06 cm) resulted from simultaneous delivery for 15 min using 4-cm antenna spacing. Conclusions: Simultaneous 4-antenna microwave ablation results in larger ablation zones than sequential ablation, and 4-cm antenna spacing with a 15-minute ablation duration creates the largest ablation zone. This information may provide multi-antenna MWA strategies for large HCC in the further clinical practice.

• OSTI ID: 22970609
• Journal Information: Cardiovascular and Interventional Radiology, Journal Name: Cardiovascular and Interventional Radiology Journal Issue: 10 Vol. 42; ISSN 0174-1551; ISSN CAIRDG
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ABLATION
ANTENNAS
CATTLE
HEPATOMAS
LIVER
MICROWAVE RADIATION