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Title: Microwave Ablation Compared with Radiofrequency Ablation for Breast Tissue in an Ex Vivo Bovine Udder Model

Abstract

Purpose: To compare the effectiveness of microwave (MW) ablation with radiofrequency (RF) ablation for treating breast tissue in a nonperfused ex vivo model of healthy bovine udder tissue. Materials and Methods: MW ablations were performed at power outputs of 25W, 35W, and 45W using a 915-MHz frequency generator and a 2-cm active tip antenna. RF ablations were performed with a bipolar RF system with 2- and 3-cm active tip electrodes. Tissue temperatures were continuously monitored during ablation. Results: The mean short-axis diameters of the coagulation zones were 1.34 {+-} 0.14, 1.45 {+-} 0.13, and 1.74 {+-} 0.11 cm for MW ablation at outputs of 25W, 35W, and 45W. For RF ablation, the corresponding values were 1.16 {+-} 0.09 and 1.26 {+-} 0.14 cm with electrodes having 2- and 3-cm active tips, respectively. The mean coagulation volumes were 2.27 {+-} 0.65, 2.85 {+-} 0.72, and 4.45 {+-} 0.47 cm{sup 3} for MW ablation at outputs of 25W, 35W, and 45W and 1.18 {+-} 0.30 and 2.29 {+-} 0.55 cm{sup 3} got RF ablation with 2- and 3-cm electrodes, respectively. MW ablations at 35W and 45W achieved significantly longer short-axis diameters than RF ablations (P < 0.05). The highest tissue temperature wasmore » achieved with MW ablation at 45W (P < 0.05). On histological examination, the extent of the ablation zone in MW ablations was less affected by tissue heterogeneity than that in RF ablations. Conclusion: MW ablation appears to be advantageous with respect to the volume of ablation and the shape of the margin of necrosis compared with RF ablation in an ex vivo bovine udder.« less

Authors:
 [1];  [2];  [1];  [2]; ;  [1];  [3]; ;  [1]
  1. RWTH Aachen University, Applied Medical Engineering, Helmholtz-Institute Aachen (Germany)
  2. RWTH Aachen University, Department of Pathology Aachen University Hospital (Germany)
  3. Nara Medical University, Department of Radiology (Japan)
Publication Date:
OSTI Identifier:
22066592
Resource Type:
Journal Article
Resource Relation:
Journal Name: Cardiovascular and Interventional Radiology; Journal Volume: 35; Journal Issue: 4; Other Information: Copyright (c) 2012 Springer Science+Business Media, LLC and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE); Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ABLATION; CATTLE; MAMMARY GLANDS; MHZ RANGE 100-1000; MICROWAVE RADIATION; NECROSIS; RADIOLOGY

Citation Formats

Tanaka, Toshihiro, E-mail: toshihir@bf6.so-net.ne.jp, Westphal, Saskia, E-mail: swestphal@ukaachen.de, Isfort, Peter, E-mail: isfort@hia.rwth-aachen.de, Braunschweig, Till, E-mail: tbraunschweig@ukaachen.de, Penzkofer, Tobias, E-mail: penzkofer@hia.rwth-aachen.de, Bruners, Philipp, E-mail: bruners@rad.rwth-aachen.de, Kichikawa, Kimihiko, E-mail: kkichika@naramed-u.ac.jp, Schmitz-Rode, Thomas, E-mail: smiro@hia.rwth-aachen.de, and Mahnken, Andreas H., E-mail: mahnken@rad.rwth-aachen.de. Microwave Ablation Compared with Radiofrequency Ablation for Breast Tissue in an Ex Vivo Bovine Udder Model. United States: N. p., 2012. Web. doi:10.1007/S00270-011-0253-4.
Tanaka, Toshihiro, E-mail: toshihir@bf6.so-net.ne.jp, Westphal, Saskia, E-mail: swestphal@ukaachen.de, Isfort, Peter, E-mail: isfort@hia.rwth-aachen.de, Braunschweig, Till, E-mail: tbraunschweig@ukaachen.de, Penzkofer, Tobias, E-mail: penzkofer@hia.rwth-aachen.de, Bruners, Philipp, E-mail: bruners@rad.rwth-aachen.de, Kichikawa, Kimihiko, E-mail: kkichika@naramed-u.ac.jp, Schmitz-Rode, Thomas, E-mail: smiro@hia.rwth-aachen.de, & Mahnken, Andreas H., E-mail: mahnken@rad.rwth-aachen.de. Microwave Ablation Compared with Radiofrequency Ablation for Breast Tissue in an Ex Vivo Bovine Udder Model. United States. doi:10.1007/S00270-011-0253-4.
Tanaka, Toshihiro, E-mail: toshihir@bf6.so-net.ne.jp, Westphal, Saskia, E-mail: swestphal@ukaachen.de, Isfort, Peter, E-mail: isfort@hia.rwth-aachen.de, Braunschweig, Till, E-mail: tbraunschweig@ukaachen.de, Penzkofer, Tobias, E-mail: penzkofer@hia.rwth-aachen.de, Bruners, Philipp, E-mail: bruners@rad.rwth-aachen.de, Kichikawa, Kimihiko, E-mail: kkichika@naramed-u.ac.jp, Schmitz-Rode, Thomas, E-mail: smiro@hia.rwth-aachen.de, and Mahnken, Andreas H., E-mail: mahnken@rad.rwth-aachen.de. Wed . "Microwave Ablation Compared with Radiofrequency Ablation for Breast Tissue in an Ex Vivo Bovine Udder Model". United States. doi:10.1007/S00270-011-0253-4.
@article{osti_22066592,
title = {Microwave Ablation Compared with Radiofrequency Ablation for Breast Tissue in an Ex Vivo Bovine Udder Model},
author = {Tanaka, Toshihiro, E-mail: toshihir@bf6.so-net.ne.jp and Westphal, Saskia, E-mail: swestphal@ukaachen.de and Isfort, Peter, E-mail: isfort@hia.rwth-aachen.de and Braunschweig, Till, E-mail: tbraunschweig@ukaachen.de and Penzkofer, Tobias, E-mail: penzkofer@hia.rwth-aachen.de and Bruners, Philipp, E-mail: bruners@rad.rwth-aachen.de and Kichikawa, Kimihiko, E-mail: kkichika@naramed-u.ac.jp and Schmitz-Rode, Thomas, E-mail: smiro@hia.rwth-aachen.de and Mahnken, Andreas H., E-mail: mahnken@rad.rwth-aachen.de},
abstractNote = {Purpose: To compare the effectiveness of microwave (MW) ablation with radiofrequency (RF) ablation for treating breast tissue in a nonperfused ex vivo model of healthy bovine udder tissue. Materials and Methods: MW ablations were performed at power outputs of 25W, 35W, and 45W using a 915-MHz frequency generator and a 2-cm active tip antenna. RF ablations were performed with a bipolar RF system with 2- and 3-cm active tip electrodes. Tissue temperatures were continuously monitored during ablation. Results: The mean short-axis diameters of the coagulation zones were 1.34 {+-} 0.14, 1.45 {+-} 0.13, and 1.74 {+-} 0.11 cm for MW ablation at outputs of 25W, 35W, and 45W. For RF ablation, the corresponding values were 1.16 {+-} 0.09 and 1.26 {+-} 0.14 cm with electrodes having 2- and 3-cm active tips, respectively. The mean coagulation volumes were 2.27 {+-} 0.65, 2.85 {+-} 0.72, and 4.45 {+-} 0.47 cm{sup 3} for MW ablation at outputs of 25W, 35W, and 45W and 1.18 {+-} 0.30 and 2.29 {+-} 0.55 cm{sup 3} got RF ablation with 2- and 3-cm electrodes, respectively. MW ablations at 35W and 45W achieved significantly longer short-axis diameters than RF ablations (P < 0.05). The highest tissue temperature was achieved with MW ablation at 45W (P < 0.05). On histological examination, the extent of the ablation zone in MW ablations was less affected by tissue heterogeneity than that in RF ablations. Conclusion: MW ablation appears to be advantageous with respect to the volume of ablation and the shape of the margin of necrosis compared with RF ablation in an ex vivo bovine udder.},
doi = {10.1007/S00270-011-0253-4},
journal = {Cardiovascular and Interventional Radiology},
number = 4,
volume = 35,
place = {United States},
year = {Wed Aug 15 00:00:00 EDT 2012},
month = {Wed Aug 15 00:00:00 EDT 2012}
}