Characterization of Calibrated Gelatin Sponge Particles in a Rabbit Renal Embolization Model

Journal Article · Thu Aug 15 04:00:00 EDT 2019 · Cardiovascular and Interventional Radiology

DOI:https://doi.org/10.1007/S00270-019-02224-7· OSTI ID:22969203

Ye, Yongsheng; Ren, Yimin ^[1]; Zeng, Hanqiang ^[2]; He, Jianxun; Zhong, Zhiwei; Wu, Xiaomei ^[1]

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1. The First Affiliated Hospital of Guangzhou Medical University, Department of Radiology (China)
2. Dongguan People’s Hospital, Department of Interventional Therapy (China)

Purpose: To evaluate the level of artery occlusion, degradation periods, tissue response and vessel recanalization of calibrated gelatin sponge particles after segmental renal artery embolization. Materials and Methods: Superselective embolization of 14 adult rabbits was performed with calibrated gelatin sponge particles (150–350 μm). Two rabbits were killed immediately after the procedure (day 0). One pair of rabbits was killed on each of the following days: 1, 3, 7, 14, 28 and 56. One rabbit from each pair underwent CT angiography before embolization and killing. The pathologic changes of the embolized renal parenchyma and embolic characteristics of calibrated gelatin sponge particles were evaluated histologically and angiographically. Results: Calibrated gelatin sponge particles were distally located in interlobular artery with a dense packing on day 0. The level of occlusion paralleled the size of the particles. Partial degradation of the particles was observed on day 3, and complete degradation was observed on day 14. Vessel recanalization was observed through both CTA and histological analysis starting on day 3. Vascular inflammation responding to gelatin sponge particles was mild and subsided with the degradation of the particles. On day 28 and day 56, attenuation of embolized vessels occurred due to marked intimal proliferation, and vascular occlusion developed. Conclusions: Gelatin sponge particles of 150–350 μm produced dense and distal embolization, and were resorbed before day 14 with a mild tissue reaction. Vessel recanalization occurred secondary to the resorption of gelatin sponge particles, but permanent vascular occlusion developed due to marked intimal hyperplasia after day 28.

• OSTI ID: 22969203
• Journal Information: Cardiovascular and Interventional Radiology, Journal Name: Cardiovascular and Interventional Radiology Journal Issue: 8 Vol. 42; ISSN 0174-1551; ISSN CAIRDG
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL TISSUES
ARTERIES
BIOMEDICAL RADIOGRAPHY
COMPUTERIZED TOMOGRAPHY
GELATIN
INFLAMMATION
KIDNEYS
RABBITS
VASCULAR DISEASES