Embolization Materials Made of Gelatin: Comparison Between Gelpart and Gelatin Microspheres
- Shiga University of Medical Science, Department of Radiology (Japan)
- Kohka Public Hospital, Department of Radiology (Japan)
- Kyoto University, Institute for Frontier Medical Sciences (Japan)
Purpose:The object of this study was to assess the level of embolization in the embolized artery and the degradation period of these two embolic agents in the renal arteries using rabbit models.Materials and Methods: The renal artery was embolized using 5 mg of gelatin microspheres (GMSs; diameter, 35-100 {mu}m; group 1) or 1 mg of Gelpart (diameter, 1 mm; group 2). For each group, angiographies were performed on two kidneys immediately after the embolic procedure and on days 3, 7, and 14 after embolization. This was followed by histopathological examinations of the kidneys.Results:Follow-up angiograms on each day revealed the persistence of poorly enhanced wedge-shaped areas in the parenchymal phase in all cases. In group 1, four of six cases showed poorly enhanced small areas in the follow-up angiograms. In group 2, all cases showed poorly enhanced large areas. In the histopathological specimens, it was observed that immediately after embolization, the particles reached the interlobular arteries in group 1 and the interlobar arteries in group 2. In all cases in group 1, the particles were histologically identified even on day 14. In one case in group 2 on day 14, the particles were not identified.Conclusion:In conclusion, although GMSs and Gelpart were similar in the point of gelatin particles, the level of embolization and the degradation period were different between GMSs and Gelpart.
- OSTI ID:
- 21429088
- Journal Information:
- Cardiovascular and Interventional Radiology, Vol. 33, Issue 1; Conference: BSIR (British Society of Interventional Radiology) 2009 annual meeting, Brighton (United Kingdom), 4-6 Nov 2009; Other Information: DOI: 10.1007/s00270-007-9139-x; Copyright (c) 2010 Springer Science+Business Media, LLC and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE); Article Copyright (c) 2007 Springer Science+Business Media, LLC; ISSN 0174-1551
- Country of Publication:
- United States
- Language:
- English
Similar Records
Gelatin Microspheres: Correlation between Embolic Effect/Degradability and Cross-linkage/Particle Size
Experimental Evaluation of Early and Long-Term Effects of Microparticle Embolization in Two Different Mini-Pig Models. Part I: Kidney