Molecular Imaging of Cardiac Amyloidosis

Journal Article · Fri Mar 15 04:00:00 EDT 2019 · Current Cardiology Reports (Print)

DOI:https://doi.org/10.1007/S11886-019-1097-9· OSTI ID:22929336

Pelletier-Galarneau, Matthieu ^[1]; Abikhzer, Gad ^[2]; Giraldeau, Genevieve ^[3]; Harel, Francois ^[1]

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1. Montreal Heart Institute, Department of Medical Imaging (Canada)
2. Jewish General Hospital, Department of Radiology and Nuclear Medicine (Canada)
3. Montreal Heart Institute, Department of Medicine (Canada)

Purpose of Review: The aim of this review is to give an update on the molecular imaging tools currently available as well as to discuss the potential roles and limitations of molecular imaging in cardiac amyloidosis. Recent Findings: Molecular imaging plays a central role in the evaluation of patients with suspected cardiac amyloidosis. It can be used to diagnose and distinguish between the different types of cardiac amyloidosis. The diagnostic properties of bone scintigraphy are such that it allows reliable diagnosis of transthyretin cardiac amyloidosis without the need of endomyocardial biopsy in a significant proportion of patients. Furthermore, molecular tracers assessing amyloid plaque burden and sympathetic innervation may be useful for the non-invasive evaluation diagnosis and risk stratification of patients with suspected cardiac amyloidosis. Summary: Cardiac amyloidosis is an under-recognized cause of left ventricular hypertrophy and heart failure in the elderly. The role of molecular imaging in cardiac amyloidosis is expected to grow considering the arrival of new therapies and molecular imaging probes.

• OSTI ID: 22929336
• Journal Information: Current Cardiology Reports (Print), Journal Name: Current Cardiology Reports (Print) Journal Issue: 3 Vol. 21; ISSN 1523-3782
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BIOPSY
DIAGNOSIS
HEART FAILURE
HYPERTROPHY
PATIENTS
POSITRON COMPUTED TOMOGRAPHY
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
SKELETON
THERAPY