The application of synthetic antibacterial minerals to combat topical infections: exploring a mouse model of MRSA infection

Morrison, Keith D.; Reiss, Meghan B.; Tanner, Tanya D.; Gollott, Travis R.; Loots, Gabriela G.; Collette, Nicole M.

doi:10.1038/s41598-024-52082-8

The application of synthetic antibacterial minerals to combat topical infections: exploring a mouse model of MRSA infection

Journal Article · Fri Jan 19 00:00:00 EST 2024 · Scientific Reports

DOI:https://doi.org/10.1038/s41598-024-52082-8· OSTI ID:2281954

Morrison, Keith D.; Reiss, Meghan B.; Tanner, Tanya D.; Gollott, Travis R.; Loots, Gabriela G.; Collette, Nicole M.

Abstract

The development of new antibiotics has stalled, and novel strategies are needed as we enter the age of antibiotic resistance. Certain naturally occurring clays have been shown to be effective in killing antibiotic resistant bacteria. However, these natural clays are too variable to be used in clinical settings. Our study shows that synthetic antibacterial minerals exhibit potent antibacterial activity against topical MRSA infections and increase the rate of wound closure relative to controls. The antibacterial minerals maintain a redox cycle between Fe ²⁺ /Fe ³⁺ and the surfaces of pyrite minerals, which act as a semiconductor and produce reactive oxygen species (ROS), while smectite minerals act as a cation exchange reservoir. Acidic conditions are maintained throughout the application of the hydrated minerals and can mitigate the alkaline pH conditions observed in chronic non-healing wounds. These results provide evidence for the strategy of ‘iron overload’ to combat antibiotic resistant infections through the maintained release of Fe ²⁺ and generation of ROS via distinct geochemical reactions that can break the chronic wound damage cycle.

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Research Organization:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

Sponsoring Organization:: USDOE; USDOE Laboratory Directed Research and Development (LDRD) Program; USDOE National Nuclear Security Administration (NNSA)

Grant/Contract Number:: AC52-07NA27344

OSTI ID:: 2281954

Alternate ID(s):: OSTI ID: 2282420

Report Number(s):: LLNL--JRNL-853143; 1762; PII: 52082

Journal Information:: Scientific Reports, Journal Name: Scientific Reports Journal Issue: 1 Vol. 14; ISSN 2045-2322

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United Kingdom

Language:: English

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