Structure–function relationships of immunostimulatory polysaccharides: A review

Ferreira, Sónia S.; Passos, Cláudia P.; Madureira, Pedro; Vilanova, Manuel; Coimbra, Manuel A.

doi:10.1016/j.carbpol.2015.05.079

Structure–function relationships of immunostimulatory polysaccharides: A review

Journal Article · Sun Nov 01 00:00:00 EDT 2015 · Carbohydrate Polymers

DOI:https://doi.org/10.1016/j.carbpol.2015.05.079· OSTI ID:2279920

Ferreira, Sónia S.; Passos, Cláudia P.; Madureira, Pedro; Vilanova, Manuel; Coimbra, Manuel A.

Not Available

View Accepted Manuscript (Publisher)

Sponsoring Organization:: USDOE

OSTI ID:: 2279920

Journal Information:: Carbohydrate Polymers, Journal Name: Carbohydrate Polymers Journal Issue: C Vol. 132; ISSN 0144-8617

Publisher:: ElsevierCopyright Statement

Country of Publication:: United Kingdom

Language:: English

References (151)

Characterization of a pectic polysaccharide from the leaves of Diospyros kaki and its modulating activity on lymphocyte proliferation Duan, Jinyou; Dong, Qun; Ding, Kan Biopolymers, Vol. 93, Issue 7 https://doi.org/10.1002/bip.21430	journal	March 2010
Studies on chemistry and immuno‐ modulating mechanism of a glycoconjugate from Lycium barbarum L. Peng, Xue‐Mei; Huang, Lin‐Juan; Qi, Chun‐Hui Chinese Journal of Chemistry, Vol. 19, Issue 12 https://doi.org/10.1002/cjoc.20010191206	journal	December 2001
Immunostimulatory properties of coffee mannans Simões, Joana; Madureira, Pedro; Nunes, Fernando M. Molecular Nutrition & Food Research, Vol. 53, Issue 8 https://doi.org/10.1002/mnfr.200800385	journal	August 2009
Humoral Pattern Recognition Molecules: Mannan-Binding Lectin and Ficolins Thiel, Steffen; Gadjeva, Mihaela Advances in Experimental Medicine and Biology https://doi.org/10.1007/978-1-4419-0901-5_5	book	January 2009
Size-exclusion chromatography (SEC) of branched polymers and polysaccharides Gaborieau, Marianne; Castignolles, Patrice Analytical and Bioanalytical Chemistry, Vol. 399, Issue 4 https://doi.org/10.1007/s00216-010-4221-7	journal	October 2010
Structure elucidation and immunological activity of a novel pectic polysaccharide from the stems of Avicennia marina Fang, Xubo; Chen, Xiaoe European Food Research and Technology, Vol. 236, Issue 2 https://doi.org/10.1007/s00217-012-1877-6	journal	December 2012
Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides S., Wasser Applied Microbiology and Biotechnology, Vol. 60, Issue 3 https://doi.org/10.1007/s00253-002-1076-7	journal	November 2002
Structural characterization and immunostimulatory activity of a novel linear α-(1 → 6)-D-glucan isolated from Panax ginseng C. A. Meyer Sun, Lin; Peng, Xiaoxia; Sun, Pan Glycoconjugate Journal, Vol. 29, Issue 5-6 https://doi.org/10.1007/s10719-012-9403-4	journal	June 2012
Chemical characterization and radioprotective effect of polysaccharide from Monostroma angicava (Chlorophyta) Mao, Wenjun; Li, Yi; Wu, Ligen Journal of Applied Phycology, Vol. 17, Issue 4 https://doi.org/10.1007/s10811-005-8360-8	journal	June 2005
Characterization and immunostimulating activity of a water-soluble polysaccharide isolated from Haematococcus lacustris Park, Jae Kweon; Kim, Z. -Hun; Lee, Choul Gyun Biotechnology and Bioprocess Engineering, Vol. 16, Issue 6 https://doi.org/10.1007/s12257-011-0173-9	journal	December 2011
Immunologically active polysaccharides of Echinacea purpurea cell cultures Wagner, Hldebert; Stuppner, Hermann; Schäfer, Wolfram Phytochemistry, Vol. 27, Issue 1 https://doi.org/10.1016/0031-9422(88)80601-0	journal	January 1988
Nitric oxide production by chicken macrophages activated by acemannan, a complex carbohydrate extracted from Aloe Vera Karaca, K.; Sharma, J. M.; Nordgren, R. International Journal of Immunopharmacology, Vol. 17, Issue 3 https://doi.org/10.1016/0192-0561(94)00102-T	journal	March 1995
The cytokine stimulating activity of (1→3)-β-d-glucans is dependent on the triple helix conformation Falch, Berit H.; Espevik, Terje; Ryan, Liv Carbohydrate Research, Vol. 329, Issue 3 https://doi.org/10.1016/S0008-6215(00)00222-6	journal	November 2000
Chemical modifications of the (1→3)-α-d-glucan from spores of Ganoderma lucidum and investigation of their physicochemical properties and immunological activity Bao, Xingfeng; Duan, Jinyou; Fang, Xuya Carbohydrate Research, Vol. 336, Issue 2 https://doi.org/10.1016/S0008-6215(01)00238-5	journal	November 2001
Structural analysis of a 4-O-methyl-glucuronoarabinoxylan with immuno-stimulating activity from Echinacea purpurea Proksch, Angelika; Wagner, Hildebert Phytochemistry, Vol. 26, Issue 7 https://doi.org/10.1016/S0031-9422(00)81744-6	journal	January 1987
Immunomodulatory activity of acidic xylans in relation to their structural and molecular properties Ebringerová, A.; Kardošová, A.; Hromádková, Z. International Journal of Biological Macromolecules, Vol. 30, Issue 1 https://doi.org/10.1016/S0141-8130(01)00186-6	journal	March 2002
Two-dimensional NMR spectroscopic studies of fenugreek (Trigonella foenum-graecum L.) galactomannan without chemical fragmentation Ramesh, H. Carbohydrate Polymers, Vol. 45, Issue 1 https://doi.org/10.1016/S0144-8617(00)00231-9	journal	May 2001
Structural characterization and antitussive activity of a glucuronoxylan from Mahonia aquifolium (Pursh) Nutt. Kardošová, A.; Malovı́ková, A.; Pätoprstý, V. Carbohydrate Polymers, Vol. 47, Issue 1 https://doi.org/10.1016/S0144-8617(00)00341-6	journal	January 2002
Effect of fenugreek (Trigonella foenum-graecum L.) galactomannan fractions on phagocytosis in rat macrophages and on proliferation and IgM secretion in HB4C5 cells Ramesh, H. Carbohydrate Polymers, Vol. 50, Issue 1 https://doi.org/10.1016/S0144-8617(01)00377-0	journal	October 2002
The immunologically active xylan from ultrasound-treated corn cobs: extractability, structure and properties Ebringerová, Anna; Hromádková, Zdena; Alfödi, Juraj Carbohydrate Polymers, Vol. 37, Issue 3 https://doi.org/10.1016/S0144-8617(98)00065-4	journal	November 1998
A complex plant cell wall polysaccharide: rhamnogalacturonan II. A structure in quest of a function Perez, S. Biochimie, Vol. 85, Issue 1-2 https://doi.org/10.1016/S0300-9084(03)00053-1	journal	January 2003
Polysaccharides from the roots of Entada africana Guill. et Perr., Mimosaceae, with complement fixing activity Diallo, Drissa; Paulsen, Berit Smestad; Liljebäck, Torun H. A. Journal of Ethnopharmacology, Vol. 74, Issue 2 https://doi.org/10.1016/S0378-8741(00)00361-5	journal	February 2001
The malian medicinal plant Trichilia emetica; studies on polysaccharides with complement fixing ability Diallo, Drissa; Paulsen, Berit Smestad; Liljebäck, Torun H. A. Journal of Ethnopharmacology, Vol. 84, Issue 2-3 https://doi.org/10.1016/S0378-8741(02)00330-6	journal	February 2003
Polysaccharide isolated from the radix of Platycodon grandiflorum selectively activates B cells and macrophages but not T cells Han, Sang B.; Park, Se H.; Lee, Ki H. International Immunopharmacology, Vol. 1, Issue 11 https://doi.org/10.1016/S1567-5769(01)00124-2	journal	October 2001
Prolongation of carrageenan-induced inflammation in human colonic epithelial cells by activation of an NFκB‐BCL10 loop Borthakur, Alip; Bhattacharyya, Sumit; Anbazhagan, Arivarasu N. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Vol. 1822, Issue 8 https://doi.org/10.1016/j.bbadis.2012.05.001	journal	August 2012
Current development of polysaccharides from Ganoderma: Isolation, structure and bioactivities Nie, Shaoping; Zhang, Hui; Li, Wenjuan Bioactive Carbohydrates and Dietary Fibre, Vol. 1, Issue 1 https://doi.org/10.1016/j.bcdf.2013.01.001	journal	January 2013
A review of isolation process, structural characteristics, and bioactivities of water-soluble polysaccharides from Dendrobium plants Xing, Xiaohui; Cui, Steve W.; Nie, Shaoping Bioactive Carbohydrates and Dietary Fibre, Vol. 1, Issue 2 https://doi.org/10.1016/j.bcdf.2013.04.001	journal	April 2013
Purification, structure and immunobiological activity of a new water-soluble polysaccharide from the mycelium of Polyporus albicans (Imaz.) Teng Sun, Y.; Wang, S.; Li, T. Bioresource Technology, Vol. 99, Issue 4 https://doi.org/10.1016/j.biortech.2007.01.029	journal	March 2008
New oligo-β-(1,3)-glucan derivatives as immunostimulating agents Descroix, Karine; Větvička, Vaclav; Laurent, Isabelle Bioorganic & Medicinal Chemistry, Vol. 18, Issue 1 https://doi.org/10.1016/j.bmc.2009.10.053	journal	January 2010
Immunological activities and structure of pectin from Centella asiatica Wang, Xue Song; Liu, Liu; Fang, Ji Nian Carbohydrate Polymers, Vol. 60, Issue 1 https://doi.org/10.1016/j.carbpol.2004.11.031	journal	April 2005
Structural characterisation of a highly branched galactomannan from the lichen Peltigera canina by methylation analysis and NMR-spectroscopy Omarsdottir, S.; Petersen, B. O.; Barsett, H. Carbohydrate Polymers, Vol. 63, Issue 1 https://doi.org/10.1016/j.carbpol.2005.07.023	journal	January 2006
Structure identification of a new immunostimulating polysaccharide from the stems of Dendrobium huoshanense Zha, Xue-Qiang; Luo, Jian-Ping; Luo, Shui-Zhong Carbohydrate Polymers, Vol. 69, Issue 1 https://doi.org/10.1016/j.carbpol.2006.09.005	journal	May 2007
Extraction optimized by using response surface methodology, purification and preliminary characterization of polysaccharides from Hyriopsis cumingii Qiao, Deliang; Hu, Bing; Gan, Dan Carbohydrate Polymers, Vol. 76, Issue 3 https://doi.org/10.1016/j.carbpol.2008.11.004	journal	April 2009
Chemical structural and chain conformational characterization of some bioactive polysaccharides isolated from natural sources Yang, Liqun; Zhang, Li-Ming Carbohydrate Polymers, Vol. 76, Issue 3 https://doi.org/10.1016/j.carbpol.2008.12.015	journal	April 2009
Carrageenans: Biological properties, chemical modifications and structural analysis – A review Campo, Vanessa Leiria; Kawano, Daniel Fábio; Silva, Dílson Braz da Carbohydrate Polymers, Vol. 77, Issue 2 https://doi.org/10.1016/j.carbpol.2009.01.020	journal	June 2009
Study on macrophage activation and structural characteristics of purified polysaccharides from the liquid culture broth of Hericium erinaceus Lee, Jong Seok; Cho, Jae Youl; Hong, Eock Kee Carbohydrate Polymers, Vol. 78, Issue 1 https://doi.org/10.1016/j.carbpol.2009.04.036	journal	August 2009
Structural features of partially acetylated coffee galactomannans presenting immunostimulatory activity Simões, Joana; Nunes, Fernando M.; Domingues, Maria do Rosário M. Carbohydrate Polymers, Vol. 79, Issue 2 https://doi.org/10.1016/j.carbpol.2009.08.020	journal	January 2010
Structural characterization of immunostimulating polysaccharide from cultured mycelia of Cordyceps militaris Lee, Jong Seok; Kwon, Jeong Seok; Yun, Jong Seok Carbohydrate Polymers, Vol. 80, Issue 4 https://doi.org/10.1016/j.carbpol.2010.01.017	journal	May 2010
Carrageenan from Solieria chordalis (Gigartinales): Structural analysis and immunological activities of the low molecular weight fractions Stephanie, Bondu; Eric, Deslandes; Sophie, Fabre Marie Carbohydrate Polymers, Vol. 81, Issue 2 https://doi.org/10.1016/j.carbpol.2010.02.046	journal	June 2010
Comparison of the immunological activities of arabinoxylans from wheat bran with alkali and xylanase-aided extraction Zhou, Sumei; Liu, Xiuzhen; Guo, Yan Carbohydrate Polymers, Vol. 81, Issue 4 https://doi.org/10.1016/j.carbpol.2010.03.040	journal	July 2010
Structural characterization of polysaccharides from Hyriopsis cumingii Qiao, Deliang; Liu, Jun; Ke, Chunling Carbohydrate Polymers, Vol. 82, Issue 4 https://doi.org/10.1016/j.carbpol.2010.06.048	journal	November 2010
Structure and biological activities of the polysaccharides from the leaves, roots and fruits of Panax ginseng C.A. Meyer: An overview Sun, Yongxu Carbohydrate Polymers, Vol. 85, Issue 3 https://doi.org/10.1016/j.carbpol.2011.03.033	journal	June 2011
Physiochemical properties and antitumor activities of two α-glucans isolated from hot water and alkaline extracts of Cordyceps (Cs-HK1) fungal mycelia Yan, Jing-Kun; Wang, Wen-Qiang; Li, Lin Carbohydrate Polymers, Vol. 85, Issue 4 https://doi.org/10.1016/j.carbpol.2011.03.043	journal	July 2011
Pectic substances: From simple pectic polysaccharides to complex pectins—A new hypothetical model Yapo, Beda M. Carbohydrate Polymers, Vol. 86, Issue 2 https://doi.org/10.1016/j.carbpol.2011.05.065	journal	August 2011
Novel highly branched water-soluble heteropolysaccharides as immunopotentiators to inhibit S-180 tumor cell growth in BALB/c mice Huang, Zhiping; Zhang, Lina; Duan, Xiaobo Carbohydrate Polymers, Vol. 87, Issue 1 https://doi.org/10.1016/j.carbpol.2011.08.001	journal	January 2012
Separation, structure characterization, conformation and immunomodulating effect of a hyperbranched heteroglycan from Radix Astragali Yin, Jun-Yi; Chan, Ben Chung-Lap; Yu, Hua Carbohydrate Polymers, Vol. 87, Issue 1 https://doi.org/10.1016/j.carbpol.2011.08.045	journal	January 2012
Effects of structural peculiarities of carrageenans on their immunomodulatory and anticoagulant activities Yermak, Irina M.; Barabanova, Anna O.; Aminin, Dmitry L. Carbohydrate Polymers, Vol. 87, Issue 1 https://doi.org/10.1016/j.carbpol.2011.08.053	journal	January 2012
Effects of alkali dissociation on the molecular conformation and immunomodulatory activity of longan pulp polysaccharide (LPI) Yi, Yang; Zhang, Ming-Wei; Liao, Sen-Tai Carbohydrate Polymers, Vol. 87, Issue 2 https://doi.org/10.1016/j.carbpol.2011.09.014	journal	January 2012
Structural characterization of an immunoregulatory polysaccharide from the fruiting bodies of Lepista sordida Luo, Qiang; Sun, Qun; Wu, Lisha Carbohydrate Polymers, Vol. 88, Issue 3 https://doi.org/10.1016/j.carbpol.2011.12.043	journal	April 2012
Isolation, structure and bioactivities of the polysaccharides from Angelica sinensis (Oliv.) Diels: A review Jin, Mingliang; Zhao, Ke; Huang, Qingsheng Carbohydrate Polymers, Vol. 89, Issue 3 https://doi.org/10.1016/j.carbpol.2012.04.049	journal	July 2012
Mass spectrometry characterization of an Aloe vera mannan presenting immunostimulatory activity Simões, Joana; Nunes, Fernando M.; Domingues, Pedro Carbohydrate Polymers, Vol. 90, Issue 1 https://doi.org/10.1016/j.carbpol.2012.05.029	journal	September 2012
Studies on wheat bran Arabinoxylan for its immunostimulatory and protective effects against avian coccidiosis Akhtar, Masood; Tariq, Ahmad Fraz; Awais, Mian Muhammad Carbohydrate Polymers, Vol. 90, Issue 1 https://doi.org/10.1016/j.carbpol.2012.05.048	journal	September 2012
Anticancer polysaccharides from natural resources: A review of recent research Zong, Aizhen; Cao, Hongzhi; Wang, Fengshan Carbohydrate Polymers, Vol. 90, Issue 4 https://doi.org/10.1016/j.carbpol.2012.07.026	journal	November 2012
Structural diversity of fungal glucans Synytsya, Andriy; Novák, Miroslav Carbohydrate Polymers, Vol. 92, Issue 1 https://doi.org/10.1016/j.carbpol.2012.09.077	journal	January 2013
Agaricus bisporus and Agaricus brasiliensis (1→6)-β-d-glucans show immunostimulatory activity on human THP-1 derived macrophages Smiderle, Fhernanda R.; Alquini, Giovana; Tadra-Sfeir, Michelle Z. Carbohydrate Polymers, Vol. 94, Issue 1 https://doi.org/10.1016/j.carbpol.2012.12.073	journal	April 2013
Activation of RAW264.7 macrophages by the polysaccharide from the roots of Actinidia eriantha and its molecular mechanisms Sun, Hongxiang; Zhang, Juan; Chen, Fengyang Carbohydrate Polymers, Vol. 121 https://doi.org/10.1016/j.carbpol.2014.12.023	journal	May 2015
Purification, structure and immunobiological activity of an arabinan-rich pectic polysaccharide from the cell walls of Prunus dulcis seeds Dourado, Fernando; Madureira, Pedro; Carvalho, Vera Carbohydrate Research, Vol. 339, Issue 15 https://doi.org/10.1016/j.carres.2004.07.024	journal	October 2004
Structural and immunological studies of a pectin and a pectic arabinogalactan from Vernonia kotschyana Sch. Bip. ex Walp. (Asteraceae) Nergard, Cecilie Sogn; Matsumoto, Tsukasa; Inngjerdingen, Marit Carbohydrate Research, Vol. 340, Issue 1 https://doi.org/10.1016/j.carres.2004.10.023	journal	January 2005
Correlation between antitumor activity, molecular weight, and conformation of lentinan Zhang, Lina; Li, Xuelian; Xu, Xiaojuan Carbohydrate Research, Vol. 340, Issue 8 https://doi.org/10.1016/j.carres.2005.02.032	journal	June 2005
Isolation, characterization and structural determination of a unique type of arabinogalactan from an immunostimulatory extract of Chlorella pyrenoidosa Suárez, Erick Reyes; Kralovec, Jaroslav A.; Noseda, Miguel D. Carbohydrate Research, Vol. 340, Issue 8 https://doi.org/10.1016/j.carres.2005.04.003	journal	June 2005
Isolation and structural characterization of an immunostimulating polysaccharide from fuzi, Aconitum carmichaeli Zhao, Chi; Li, Min; Luo, Yifan Carbohydrate Research, Vol. 341, Issue 4 https://doi.org/10.1016/j.carres.2005.11.032	journal	March 2006
Structural elucidation and immuno-stimulating activity of an acidic heteropolysaccharide (TAPA1) from Tremella aurantialba Du, XiuJu; Zhang, JingSong; Yang, Yan Carbohydrate Research, Vol. 344, Issue 5 https://doi.org/10.1016/j.carres.2009.01.021	journal	March 2009
Physicochemical properties and antitumor activities for sulfated derivatives of lentinan Wang, Xiaohua; Zhang, Lina Carbohydrate Research, Vol. 344, Issue 16 https://doi.org/10.1016/j.carres.2009.04.033	journal	November 2009
Studies on the chemical structure and antitumor activity of an exopolysaccharide from Rhizobium sp. N613 Zhao, Liangqi; Chen, Yanli; Ren, Sheng Carbohydrate Research, Vol. 345, Issue 5 https://doi.org/10.1016/j.carres.2009.11.017	journal	March 2010
Isolation of phosphorylated polysaccharides from algae: the immunostimulatory principle of Chlorella pyrenoidosa Suárez, Erick Reyes; Kralovec, Jaroslav A.; Bruce Grindley, T. Carbohydrate Research, Vol. 345, Issue 9 https://doi.org/10.1016/j.carres.2010.04.004	journal	June 2010
A partially methylated mannogalactan from hybrid mushroom pfle 1p: purification, structural characterization, and study of immunoactivation Maity, Prasenjit; Pattanayak, Manabendra; Maity, Saikat Carbohydrate Research, Vol. 395 https://doi.org/10.1016/j.carres.2014.06.004	journal	August 2014
Fructooligosaccharides and fructans analysis in plants and food crops Benkeblia, Noureddine Journal of Chromatography A, Vol. 1313 https://doi.org/10.1016/j.chroma.2013.08.013	journal	October 2013
The invention of lymphocytes Hsu, Ellen Current Opinion in Immunology, Vol. 23, Issue 2 https://doi.org/10.1016/j.coi.2010.12.007	journal	April 2011
Antitumor and immunostimulatory activity of a polysaccharide–protein complex from Scolopendra subspinipes mutilans L. Koch in tumor-bearing mice Zhao, Haixia; Li, Ying; Wang, Yuzhong Food and Chemical Toxicology, Vol. 50, Issue 8 https://doi.org/10.1016/j.fct.2012.05.018	journal	August 2012
Immunostimulatory and antiangiogenic activities of low molecular weight hyaluronic acid Ke, Chunlin; Wang, Di; Sun, Yi Food and Chemical Toxicology, Vol. 58 https://doi.org/10.1016/j.fct.2013.05.032	journal	August 2013
Characterisation and immunostimulatory activity of an α-(1→6)-d-glucan from the cultured Armillariella tabescens mycelia Luo, Xia; Xu, Xiaoyan; Yu, Mengyao Food Chemistry, Vol. 111, Issue 2 https://doi.org/10.1016/j.foodchem.2008.03.076	journal	November 2008
Chemical modification of an acidic polysaccharide (TAPA1) from Tremella aurantialba and potential biological activities Du, XiuJu; Zhang, JingSong; Lv, ZhiWei Food Chemistry, Vol. 143 https://doi.org/10.1016/j.foodchem.2013.07.137	journal	January 2014
A review on the isolation and structure of tea polysaccharides and their bioactivities Nie, Shao-Ping; Xie, Ming-Yong Food Hydrocolloids, Vol. 25, Issue 2 https://doi.org/10.1016/j.foodhyd.2010.04.010	journal	March 2011
Immunomodulatory effects of fructans Delgado, Grethel T. Choque; Tamashiro, Wirla M. S. C.; Pastore, Glaucia M. Food Research International, Vol. 43, Issue 5 https://doi.org/10.1016/j.foodres.2010.04.023	journal	June 2010
ß-glucans as conductors of immune symphonies Dalmo, Roy A.; Bøgwald, Jarl Fish & Shellfish Immunology, Vol. 25, Issue 4 https://doi.org/10.1016/j.fsi.2008.04.008	journal	October 2008
Norway spruce galactoglucomannans exhibiting immunomodulating and radical-scavenging activities Ebringerová, Anna; Hromádková, Zdenka; Hříbalová, Vera International Journal of Biological Macromolecules, Vol. 42, Issue 1 https://doi.org/10.1016/j.ijbiomac.2007.08.001	journal	January 2008
Immunostimulatory activity of the polysaccharides from Hyriopsis cumingii Qiao, Deliang; Luo, Jianguang; Ke, Chunling International Journal of Biological Macromolecules, Vol. 47, Issue 5 https://doi.org/10.1016/j.ijbiomac.2010.08.014	journal	December 2010
Antitussive and immunomodulating activities of instant coffee arabinogalactan-protein Nosáľová, G.; Prisenžňáková, L.; Paulovičová, E. International Journal of Biological Macromolecules, Vol. 49, Issue 4 https://doi.org/10.1016/j.ijbiomac.2011.06.004	journal	November 2011
Immuno-modulation effect of sulphated polysaccharide (porphyran) from Porphyra vietnamensis Bhatia, Saurabh; Rathee, Permender; Sharma, Kiran International Journal of Biological Macromolecules, Vol. 57 https://doi.org/10.1016/j.ijbiomac.2013.03.012	journal	June 2013
Immunostimulatory activity and structure of polysaccharide from Streptococcus equi subsp. zooepidemicus Ke, Chunlin; Qiao, Deliang; Luo, Jianguang International Journal of Biological Macromolecules, Vol. 57 https://doi.org/10.1016/j.ijbiomac.2013.03.033	journal	June 2013
Anti-tumor activity of the regenerated triple-helical polysaccharide from Dictyophora indusiata Deng, Chao; Fu, Haitian; Teng, Liping International Journal of Biological Macromolecules, Vol. 61 https://doi.org/10.1016/j.ijbiomac.2013.08.007	journal	October 2013
Induction of secretory and tumoricidal activities in peritoneal macrophages activated by an acidic heteropolysaccharide (ARAGAL) from the gum of Anadenanthera colubrina (Angico branco) Moretão, Mariana Piemonte; Zampronio, Aleksander Roberto; Gorin, Philip A. J. Immunology Letters, Vol. 93, Issue 2-3 https://doi.org/10.1016/j.imlet.2004.03.021	journal	May 2004
Polysaccharide biological response modifiers Leung, M. Y. K.; Liu, C.; Koon, J. C. M. Immunology Letters, Vol. 105, Issue 2 https://doi.org/10.1016/j.imlet.2006.01.009	journal	June 2006
Immune stimulating properties of a novel polysaccharide from the medicinal plant Tinospora cordifolia Raveendran Nair, P. K.; Rodriguez, Sonia; Ramachandran, Reshma International Immunopharmacology, Vol. 4, Issue 13 https://doi.org/10.1016/j.intimp.2004.07.024	journal	January 2004
Identification of optimal molecular size of modified Aloe polysaccharides with maximum immunomodulatory activity Im, Sun-A; Oh, Sun-Tack; Song, Sukgil International Immunopharmacology, Vol. 5, Issue 2 https://doi.org/10.1016/j.intimp.2004.09.031	journal	February 2005
Characterization and immunostimulatory activity of an (1→6)-a-d-glucan from the root of Ipomoea batatas Zhao, Guohua; Kan, Jianquan; Li, Zhixiao International Immunopharmacology, Vol. 5, Issue 9 https://doi.org/10.1016/j.intimp.2005.03.012	journal	August 2005
Macrophage immunomodulatory activity of polysaccharides isolated from Juniperus scopolorum Schepetkin, Igor A.; Faulkner, Craig L.; Nelson-Overton, Laura K. International Immunopharmacology, Vol. 5, Issue 13-14 https://doi.org/10.1016/j.intimp.2005.05.009	journal	December 2005
Botanical polysaccharides: Macrophage immunomodulation and therapeutic potential Schepetkin, Igor A.; Quinn, Mark T. International Immunopharmacology, Vol. 6, Issue 3 https://doi.org/10.1016/j.intimp.2005.10.005	journal	March 2006
Immunomodulatory activity of acidic polysaccharides isolated from Tanacetum vulgare L. Xie, Gang; Schepetkin, Igor A.; Quinn, Mark T. International Immunopharmacology, Vol. 7, Issue 13 https://doi.org/10.1016/j.intimp.2007.08.013	journal	December 2007
Macrophage immunomodulatory activity of polysaccharides isolated from Opuntia polyacantha Schepetkin, Igor A.; Xie, Gang; Kirpotina, Liliya N. International Immunopharmacology, Vol. 8, Issue 10 https://doi.org/10.1016/j.intimp.2008.06.003	journal	October 2008
Characterization and immunostimulatory activity of a polysaccharide from the spores of Ganoderma lucidum Guo, Liang; Xie, Jianhui; Ruan, Yuanyuan International Immunopharmacology, Vol. 9, Issue 10 https://doi.org/10.1016/j.intimp.2009.06.005	journal	September 2009
Bioactive pectic polysaccharides from Glinus oppositifolius (L.) Aug. DC., a Malian medicinal plant, isolation and partial characterization Inngjerdingen, Kari Tvete; Debes, Sylvi C.; Inngjerdingen, Marit Journal of Ethnopharmacology, Vol. 101, Issue 1-3 https://doi.org/10.1016/j.jep.2005.04.021	journal	October 2005
Polysaccharides with complement fixing and macrophage stimulation activity from Opilia celtidifolia, isolation and partial characterisation Togola, Adiaratou; Inngjerdingen, Marit; Diallo, Drissa Journal of Ethnopharmacology, Vol. 115, Issue 3 https://doi.org/10.1016/j.jep.2007.10.017	journal	February 2008
In vivo antitumor and immunomodulation activities of different molecular weight lambda-carrageenans from Chondrus ocellatus Zhou, G. Pharmacological Research, Vol. 50, Issue 1 https://doi.org/10.1016/j.phrs.2003.12.002	journal	July 2004
Effects of lichen heteroglycans on proliferation and IL-10 secretion by rat spleen cells and IL-10 and TNF-α secretion by rat peritoneal macrophages in vitro Omarsdottir, S.; Freysdottir, J.; Barsett, H. Phytomedicine, Vol. 12, Issue 6-7 https://doi.org/10.1016/j.phymed.2004.03.012	journal	June 2005
Water-soluble polysaccharides from Salvia officinalis L. possessing immunomodulatory activity Capek, Peter; Hřı́balová, Vĕra Phytochemistry, Vol. 65, Issue 13 https://doi.org/10.1016/j.phytochem.2004.05.020	journal	July 2004
An immunomodulating pectic polymer from Glinus oppositifolius Inngjerdingen, Kari T.; Kiyohara, Hiroaki; Matsumoto, Tsukasa Phytochemistry, Vol. 68, Issue 7 https://doi.org/10.1016/j.phytochem.2007.01.011	journal	April 2007
Fractionation and characterization of biologically-active polysaccharides from Artemisia tripartita Xie, Gang; Schepetkin, Igor A.; Siemsen, Daniel W. Phytochemistry, Vol. 69, Issue 6 https://doi.org/10.1016/j.phytochem.2008.01.009	journal	April 2008
Rhamnoarabinosyl and rhamnoarabinoarabinosyl side chains as structural features of coffee arabinogalactans Nunes, Fernando M.; Reis, Ana; Silva, Artur M. S. Phytochemistry, Vol. 69, Issue 7 https://doi.org/10.1016/j.phytochem.2008.01.021	journal	May 2008
Isolation, structural elucidation and immunomodulatory activity of fructans from aged garlic extract Chandrashekar, Puthanapura M.; Prashanth, Keelara V. Harish; Venkatesh, Yeldur P. Phytochemistry, Vol. 72, Issue 2-3 https://doi.org/10.1016/j.phytochem.2010.11.015	journal	February 2011
Beta-d-(1→4)-galactan-containing side chains in RG-I regions of pectic polysaccharides from Biophytum petersianum Klotzsch. contribute to expression of immunomodulating activity against intestinal Peyer’s patch cells and macrophages Grønhaug, Tom Erik; Kiyohara, Hiroaki; Sveaass, Anne Phytochemistry, Vol. 72, Issue 17 https://doi.org/10.1016/j.phytochem.2011.08.011	journal	December 2011
Immunostimulatory Polysaccharides from Chlorella pyrenoidosa. A New Galactofuranan. Measurement of Molecular Weight and Molecular Weight Dispersion by DOSY NMR Suárez, Erick Reyes; Syvitski, Raymond; Kralovec, Jaroslav A. Biomacromolecules, Vol. 7, Issue 8 https://doi.org/10.1021/bm060365x	journal	June 2006
Characterization of Aloeride, a New High-Molecular-Weight Polysaccharide from Aloe vera with Potent Immunostimulatory Activity Pugh, Nirmal; Ross, Samir A.; ElSohly, Mahmoud A. Journal of Agricultural and Food Chemistry, Vol. 49, Issue 2 https://doi.org/10.1021/jf001036d	journal	December 2000
Structural Ripening-Related Changes of the Arabinan-Rich Pectic Polysaccharides from Olive Pulp Cell Walls Cardoso, Susana M.; Ferreira, José A.; Mafra, Isabel Journal of Agricultural and Food Chemistry, Vol. 55, Issue 17 https://doi.org/10.1021/jf070769w	journal	July 2007
In Vivo Anti-influenza Virus Activity of an Immunomodulatory Acidic Polysaccharide Isolated from Cordyceps militaris Grown on Germinated Soybeans Ohta, Yuko; Lee, Jung-Bum; Hayashi, Kyoko Journal of Agricultural and Food Chemistry, Vol. 55, Issue 25 https://doi.org/10.1021/jf0721287	journal	November 2007
Improved Purity and Immunostimulatory Activity of β-(1→3)(1→6)-Glucan from Pleurotus sajor-caju Using Cell Wall-Degrading Enzymes Satitmanwiwat, Saranya; Ratanakhanokchai, Khanok; Laohakunjit, Natta Journal of Agricultural and Food Chemistry, Vol. 60, Issue 21 https://doi.org/10.1021/jf300354x	journal	May 2012
Structure and Immuno-Stimulating Activities of a New Heteropolysaccharide from Lentinula edodes Xu, Xiaofei; Yan, Huidan; Zhang, Xuewu Journal of Agricultural and Food Chemistry, Vol. 60, Issue 46 https://doi.org/10.1021/jf304364c	journal	November 2012
Polysaccharides from Dioscorea batatas Induce Tumor Necrosis Factor-α Secretion via Toll-like Receptor 4-Mediated Protein Kinase Signaling Pathways Liu, Ju-Yun; Yang, Feng-Ling; Lu, Chun-Ping Journal of Agricultural and Food Chemistry, Vol. 56, Issue 21 https://doi.org/10.1021/jf8018722	journal	October 2008
Structural Characterization, Chain Conformation, and Morphology of a β-(1→3)-d-Glucan Isolated from the Fruiting Body of Dictyophora indusiata Wang, Jiatang; Xu, Xiaojuan; Zheng, Hua Journal of Agricultural and Food Chemistry, Vol. 57, Issue 13 https://doi.org/10.1021/jf9009872	journal	June 2009
Enhancement of Antitumor Activities in Sulfated and Carboxymethylated Polysaccharides of Ganoderma lucidum Wang, Jianguo; Zhang, Lina; Yu, Yonghui Journal of Agricultural and Food Chemistry, Vol. 57, Issue 22 https://doi.org/10.1021/jf902597w	journal	October 2009
A Fructan, from Radix Ophiopogonis, Stimulates the Proliferation of Cultured Lymphocytes: Structural and Functional Analyses Wu, Xiangmei; Dai, Hui; Huang, Lixin Journal of Natural Products, Vol. 69, Issue 9 https://doi.org/10.1021/np060033d	journal	August 2006
Effects of α-glucans from Agaricus bisporus on ex vivo cytokine production by LPS and PHA-stimulated PBMCs; a placebo-controlled study in slightly hypercholesterolemic subjects Volman, J. J.; Mensink, R. P.; van Griensven, L. J. L. D. European Journal of Clinical Nutrition, Vol. 64, Issue 7 https://doi.org/10.1038/ejcn.2010.32	journal	March 2010
The complement system in regulation of adaptive immunity Carroll, Michael C. Nature Immunology, Vol. 5, Issue 10 https://doi.org/10.1038/ni1113	journal	September 2004
The history of Toll-like receptors — redefining innate immunity O'Neill, Luke A. J.; Golenbock, Douglas; Bowie, Andrew G. Nature Reviews Immunology, Vol. 13, Issue 6 https://doi.org/10.1038/nri3446	journal	May 2013
Scavenger receptors in homeostasis and immunity Canton, Johnathan; Neculai, Dante; Grinstein, Sergio Nature Reviews Immunology, Vol. 13, Issue 9 https://doi.org/10.1038/nri3515	journal	August 2013
Natural glycans and glycoconjugates as immunomodulating agents Chlubnová, Ilona; Sylla, Balla; Nugier-Chauvin, Caroline Natural Product Reports, Vol. 28, Issue 5 https://doi.org/10.1039/c1np00005e	journal	January 2011
Studies in immuno-chemistry Morgan, Walter Thomas James Biochemical Journal, Vol. 30, Issue 5 https://doi.org/10.1042/bj0300909	journal	May 1936
Interaction Between Human Complement and a Pectin Type Polysaccharide Fraction, PMII, from the Leaves of Plantago major L. Michaelsen, T. E.; Gilje, A.; Samuelsen, A. B. Scandinavian Journal of Immunology, Vol. 52, Issue 5 https://doi.org/10.1046/j.1365-3083.2000.00801.x	journal	November 2000
Modified Aloe barbadensis Polysaccharide with Immunoregulatory Activity Qiu*, Zhihua; Jones, Ken; Wylie, Mark Planta Medica, Vol. 66, Issue 2 https://doi.org/10.1055/s-2000-11125	journal	March 2000
Ligands of Macrophage Scavenger Receptor Induce Cytokine Expression via Differential Modulation of Protein Kinase Signaling Pathways Hsu, Hsien-Yeh; Chiu, Show-Lan; Wen, Meng-Hsuan Journal of Biological Chemistry, Vol. 276, Issue 31 https://doi.org/10.1074/jbc.M011117200	journal	August 2001
MD-2-mediated Ionic Interactions between Lipid A and TLR4 Are Essential for Receptor Activation Meng, Jianmin; Lien, Egil; Golenbock, Douglas T. Journal of Biological Chemistry, Vol. 285, Issue 12 https://doi.org/10.1074/jbc.M109.075127	journal	March 2010
Immunostimulatory Activity of Fucoidan from the Brown AlgaFucus evanescens: Role of Sulfates and Acetates Khil’chenko, Stanislav R.; Zaporozhets, Tatiana S.; Shevchenko, Natalia M. Journal of Carbohydrate Chemistry, Vol. 30, Issue 4-6 https://doi.org/10.1080/07328303.2011.604456	journal	May 2011
Polysaccharides inLentinus edodes: Isolation, Structure, Immunomodulating Activity and Future Prospective Xu, Xiaofei; Yan, Huidan; Tang, Jian Critical Reviews in Food Science and Nutrition, Vol. 54, Issue 4 https://doi.org/10.1080/10408398.2011.587616	journal	November 2013
The influence of glucan polymer structure and solution conformation on binding to (1->3)- -D-glucan receptors in a human monocyte-like cell line Mueller, A.; Raptis, J.; Rice, P. J. Glycobiology, Vol. 10, Issue 4 https://doi.org/10.1093/glycob/10.4.339	journal	April 2000
Chemical and biological characterization of a polysaccharide biological response modifier from Aloe vera L. var. chinensis (Haw.) Berg. Leung, M. Y. K. Glycobiology, Vol. 14, Issue 6 https://doi.org/10.1093/glycob/cwh050	journal	January 2004
Glucan-like synthetic oligosaccharides: iterative synthesis of linear oligo-β-(1,3)-glucans and immunostimulatory effects Jamois, Frank; Ferrières, Vincent; Guégan, Jean-Paul Glycobiology, Vol. 15, Issue 4 https://doi.org/10.1093/glycob/cwi020	journal	December 2004
Immunological and Structural Properties of a Pectic Polymer from Glinus Oppositifolius Inngjerdingen, Kari T.; Patel, Trushar R.; Chen, Xinyong Glycobiology, Vol. 17, Issue 12 https://doi.org/10.1093/glycob/cwm088	journal	August 2007
Differential regulation of oxidative burst by distinct β-glucan-binding receptors and signaling pathways in human peripheral blood mononuclear cells Bose, Nandita; Wurst, Lindsay R.; Chan, Anissa S. H. Glycobiology, Vol. 24, Issue 4 https://doi.org/10.1093/glycob/cwu005	journal	January 2014
Macrophage Activation by the Polysaccharide Arabinogalactan Isolated From Plant Cell Cultures of Echinacea purpurea Luettig, B.; Steinmuller, C.; Gifford, G. E. JNCI Journal of the National Cancer Institute, Vol. 81, Issue 9 https://doi.org/10.1093/jnci/81.9.669	journal	May 1989
Levan (beta-2, 6-fructan), a major fraction of fermented soybean mucilage, displays immunostimulating properties via Toll-like receptor 4 signalling: induction of interleukin-12 production and suppression of T-helper type 2 response and immunoglobulin E production Xu, Q.; Yajima, T.; Li, W. Clinical Experimental Allergy, Vol. 36, Issue 1 https://doi.org/10.1111/j.1365-2222.2006.02401.x	journal	January 2006
Sensing of microbial molecular patterns by Toll‐like receptors Song, Dong Hyun; Lee, Jie‐Oh Immunological Reviews, Vol. 250, Issue 1 https://doi.org/10.1111/j.1600-065X.2012.01167.x	journal	October 2012
mTOR- and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity Cheng, Shih-Chin; Quintin, Jessica; Cramer, Robert A. Science, Vol. 345, Issue 6204 https://doi.org/10.1126/science.1250684	journal	September 2014
Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity Saeed, Sadia; Quintin, Jessica; Kerstens, Hindrik H. D. Science, Vol. 345, Issue 6204 https://doi.org/10.1126/science.1251086	journal	September 2014
The Instructive Role of Innate Immunity in the Acquired Immune Response Fearon, Douglas T.; Locksley, Richard M. Science, Vol. 272, Issue 5258 https://doi.org/10.1126/science.272.5258.50	journal	April 1996
Polysaccharide Immunomodulators as Therapeutic Agents: Structural Aspects and Biologic Function Tzianabos, Arthur O. Clinical Microbiology Reviews, Vol. 13, Issue 4 https://doi.org/10.1128/CMR.13.4.523	journal	October 2000
Macrophage activation and induction of macrophage cytotoxicity by purified polysaccharide fractions from the plant Echinacea purpurea Stimpel, M.; Proksch, A.; Wagner, H. Infection and Immunity, Vol. 46, Issue 3 https://doi.org/10.1128/IAI.46.3.845-849.1984	journal	December 1984
Polypotency of the immunomodulatory effect of pectins Popov, S. V.; Ovodov, Yu. S. Biochemistry (Moscow), Vol. 78, Issue 7 https://doi.org/10.1134/S0006297913070134	journal	July 2013
Polysaccharide Conformation and Cell Wall Function Preston, R. D. Annual Review of Plant Physiology, Vol. 30, Issue 1 https://doi.org/10.1146/annurev.pp.30.060179.000415	journal	June 1979
Carrageenan-Induced Colonic Inflammation Is Reduced in Bcl10 Null Mice and Increased in IL-10-Deficient Mice Bhattacharyya, Sumit; Xue, Liquan; Devkota, Suzanne Mediators of Inflammation, Vol. 2013 https://doi.org/10.1155/2013/397642	journal	January 2013
Ligand of scavenger receptor class A indirectly induces maturation of human blood dendritic cells via production of tumor necrosis factor-α Jin, Jun-O; Park, Hae-Young; Xu, Qi Blood, Vol. 113, Issue 23 https://doi.org/10.1182/blood-2008-10-184796	journal	June 2009
Polysaccharides from Agaricus bisporus and Agaricus brasiliensis show similarities in their structures and their immunomodulatory effects on human monocytic THP-1 cells Smiderle, Fhernanda R.; Ruthes, Andrea C.; van Arkel, Jeroen BMC Complementary and Alternative Medicine, Vol. 11, Issue 1 https://doi.org/10.1186/1472-6882-11-58	journal	July 2011
Immunomodulatory dietary polysaccharides: a systematic review of the literature Ramberg, Jane E.; Nelson, Erika D.; Sinnott, Robert A. Nutrition Journal, Vol. 9, Issue 1 https://doi.org/10.1186/1475-2891-9-54	journal	November 2010
Comparison of the Immunopharmacological Activities of Triple and Single-Helical Schizophyllan in Mice. Ohno, Naohito; Miura, Noriko N.; Chiba, Norihisa Biological and Pharmaceutical Bulletin, Vol. 18, Issue 9 https://doi.org/10.1248/bpb.18.1242	journal	January 1995
Fucoidan Isolated from Laminaria angustata var. longissima Induced Macrophage Activation Teruya, Takeshi; Takeda, Shinji; Tamaki, Yukihiro Bioscience, Biotechnology, and Biochemistry, Vol. 74, Issue 9 https://doi.org/10.1271/bbb.100294	journal	September 2010
Dietary Fructooligosaccharides Induce Immunoregulation of Intestinal IgA Secretion by Murine Peyer's Patch Cells Hosono, Akira; Ozawa, Akane; Kato, Rina Bioscience, Biotechnology, and Biochemistry, Vol. 67, Issue 4 https://doi.org/10.1271/bbb.67.758	journal	January 2003
Polysaccharides Isolated from Açaí Fruit Induce Innate Immune Responses Holderness, Jeff; Schepetkin, Igor A.; Freedman, Brett PLoS ONE, Vol. 6, Issue 2 https://doi.org/10.1371/journal.pone.0017301	journal	February 2011
Nasal Acai Polysaccharides Potentiate Innate Immunity to Protect against Pulmonary Francisella tularensis and Burkholderia pseudomallei Infections Skyberg, Jerod A.; Rollins, MaryClare F.; Holderness, Jeff S. PLoS Pathogens, Vol. 8, Issue 3 https://doi.org/10.1371/journal.ppat.1002587	journal	March 2012
Purification, chemical modification and immunostimulating activity of polysaccharides from Tremella aurantialba fruit bodies Du, Xiu-ju; Zhang, Jing-song; Yang, Yan Journal of Zhejiang University SCIENCE B, Vol. 11, Issue 6 https://doi.org/10.1631/jzus.B0900402	journal	May 2010
Immunomodulatory Activity of Dietary Fiber: Arabinoxylan and Mixed-Linked Beta-Glucan Isolated from Barley Show Modest Activities in Vitro Samuelsen, Anne Berit; Rieder, Anne; Grimmer, Stine International Journal of Molecular Sciences, Vol. 12, Issue 1 https://doi.org/10.3390/ijms12010570	journal	January 2011
Fucoidan: Structure and Bioactivity Li, Bo; Lu, Fei; Wei, Xinjun Molecules, Vol. 13, Issue 8 https://doi.org/10.3390/molecules13081671	journal	August 2008
Immunostimulatory properties and antitumor activities of glucans Vannucci, Luca; Krizan, Jiri; Sima, Petr International Journal of Oncology, Vol. 43, Issue 2 https://doi.org/10.3892/ijo.2013.1974	journal	June 2013

Similar Records

Plant immunophilins: a review of their structure-function relationship

Journal Article · Wed Sep 30 20:00:00 EDT 2015 · Biochimica et Biophysica Acta - General Subjects · OSTI ID:1342594

Structure–function relationships of immunostimulatory polysaccharides: A review

Citation Formats

References (151)

Similar Records

Related Subjects